MICROS2009
Scientific Programme
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Sunday, October 25, 2009
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15.00-18.00 Registration at the “Congress Centre” – Hotel San Marco, Verona
Registration Desk will remain open from Monday Oct. 26 to Friday Oct. 30 throughout the Symposium Scientific Sessions.
17.30-19.00 Opening Cerimony:
Opening Addresses
Opening lecture: H.H Rossi Lecture: Herwig Paretzke, Germany
Microdosimetry, Track Structures and their Impact on Radiation Risk Assessment
19.30 Welcome Party at the “Hotel San Marco”
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Monday, October 26, 2009
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8.15-9.15 Refresher Course:
Francis A. Cucinotta, USA
Nuclear interactions in heavy ion transport and event-based risk models
9.15-10.45 Session I - Physics and Chemistry of Radiation Tracks
Michael Dingfelder, USA (invited)
Heavy ion track structure simulations in liquid water and bone
Ianik Plante, USA
3D Visualization of Monte-Carlo simulation’s of HZE Track Structure and Initial Chemical Species
3D Visualization of Monte-Carlo simulation’s of HZE Track Structure and Initial Chemical Species
Chantal Houée Levin, France
Do oxygen free radicals exert a retro-control on the production of superoxide ions by NADPH oxidase?
Do oxygen free radicals exert a retro-control on the production of superoxide ions by NADPH oxidase?
A radiolysis study
10.45 Coffee-Break
11.15-13.15 Session II - Modeling of Radiation Action
Werner Friedland, Germany (invited)
Mechanistic simulation of radiation damage to DNA and repair on the track
towards systems radiation biology modelling
Carmen Villagrasa, France
Track structure calculations at molecular scale for the undestranding of initial radio-induced damages in DNA
Track structure calculations at molecular scale for the undestranding of initial radio-induced damages in DNA
Shaowen Hu, USA
Computational study on full-length human Ku70 with double stranded DNA: dynamics, interactions and
Computational study on full-length human Ku70 with double stranded DNA: dynamics, interactions and
functional implications
Tatsuhiko Sato, Japan
Analysis of cell-survival-fraction data for various heavy ion irradiations based on the microdosimetric kinetic
Analysis of cell-survival-fraction data for various heavy ion irradiations based on the microdosimetric kinetic
model implemented in the PHITS code
In Memoriam: Aloke Chatterjee (1940-2009)
Mary Helen Barcellos-Hoff, USA
13.15 Lunch at the “Hotel San Marco”
14.30-16.00 Session III - DNA Damage Response and Radiation Quality
Daniele Alloni, Italy
Monte Carlo evaluation of DNA fragmentation spectra induced by different radiation qualities
Monte Carlo evaluation of DNA fragmentation spectra induced by different radiation qualities
Giuseppe Schettino, UK
Spatio-temporal investigations of DNA damage repair using microbeam facilities
Spatio-temporal investigations of DNA damage repair using microbeam facilities
Yoshiya Furusawa, Japan
Misrepair of DNA Double Strand Breaks causes the peak of LET-RBE relationship on cell killing
Misrepair of DNA Double Strand Breaks causes the peak of LET-RBE relationship on cell killing
Marlis Frankenberg-Schwager, Germany
Chromosomal instability induced by 29 kV mammography X-rays in cells from mutation carriers predisposed
Chromosomal instability induced by 29 kV mammography X-rays in cells from mutation carriers predisposed
to breast cancer
16.00 Coffee-Break
16.30-18.30 Session IV - DNA Damage by Auger Electrons
Amin I. Kassis, USA (invited)
Molecular and cellular radiobiological effects of Auger emitting radionuclides
Roger Howell, USA (invited)
Closing the gap between dose and effect for Auger electron and other internal emitters
Fang-yuh Hsu, Taiwan
Cellular dosimetry and microdosimetry for internal electron emitters
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Tuesday, October 27, 2009
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8.15-9.15 Refresher Course:
Peter O’Neill, UK
Radiation-induced DNA damage complexity and repair
9.15-11.00 Session V – Genomic Instability, Gene Expression and Signalling
Anna Saran, Italy (invited)
Long-range radiation damage to unexposed mouse brain: mechanisms and significance
Sally Amundson, USA (invited)
Radiation induced changes in gene expression: novel responses at low dose
Svetlana Sorokina, Russia
Delayed effects of chronic low-dose high-LET radiation on mice in vivo
Delayed effects of chronic low-dose high-LET radiation on mice in vivo
Abdelrazek Abdelrazzak, UK
The importance of the radiation track structure in the stimulation of intercellular induction of apoptosis
The importance of the radiation track structure in the stimulation of intercellular induction of apoptosis
in transformed cells following exposures of very low doses of high and low-LET radiation
11.00 Coffee-Break
11.30-13.00 Session VI –Low Dose Effects
Phil Hahnfeldt, USA (invited)
Tissue population action in low dose cancer risk
Marianne Sowa, USA
Lack of evidence for low-LET radiation induced bystander response in normal human fibroblasts and colon
Lack of evidence for low-LET radiation induced bystander response in normal human fibroblasts and colon
carcinoma cells
Peter Jacob, Germany
Possible expression of a bystander effect with a dose threshold in lung cancer mortality of Mayak workers
Possible expression of a bystander effect with a dose threshold in lung cancer mortality of Mayak workers
Sergey Andreev, Russia
Dose response prediction for Radiation induced chromosomal instability
Dose response prediction for Radiation induced chromosomal instability
13.00 Lunch at the “Hotel San Marco”
14.30-16.00 Session VII – Microbeams and Biological Applications
Kevin Prise, UK (invited)
Use of microbeams and biological findings. Review and critical comparison
Katsumi Kobayashi, Japan
Development of an X-ray microbeam system to irradiate cytoplasm only of mammalian cells using SR X-rays.
Development of an X-ray microbeam system to irradiate cytoplasm only of mammalian cells using SR X-rays.
Guy Garty, USA
Design of a novel Flow-and Shoot (FAST) microbeam
16.00 Coffee-Break
16.30-18.30 Session VIII - POSTER SESSION
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Wednesday, October 28, 2009
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8.15-9.15 Refresher Course:
William Bonner, USA
H2AX phosphorylation in response to DNA double-strand break formation
9.15-11.00 Session IX – Radiation Carcinogenesis
Mary Helen Barcellos-Hoff, USA (invited)
Do non-targeted effects matter in radiation carcinogenesis?
David Brenner, USA (invited)
A new view of radiation-induced cancer
Harmen Bijwaard, Netherlands
Breast cancer risk due to mammography screening
Breast cancer risk due to mammography screening
Markus Eidemüller, Germany
Breast cancer risk among Swedish hemangioma patients and possible consequences of radiation-induced
Breast cancer risk among Swedish hemangioma patients and possible consequences of radiation-induced
genomic instability
11.00 Coffee-Break
11.30-13.00 Session X – Physics and Radiobiology for Space Radiation Protection
Marco Durante, Germany (invited)
Cellular effects induced by energetic heavy ions: from DNA breaks to chromosomal rearrangements
Sylvain Costes, USA (invited)
Evidence of DSB clustering and consequences for Radiation Induced Foci kinetic for low and high LET
Gunther Reitz, Germany
Effective Dose Determination for Astronauts Using the MATROSHKA Experiment
Shiuchi Tsuda, Japan
Microdosimetry for heavy ion beams using a Wall-Less Tissue Equivalent Proportional Counter
Katerina Brabcova, Czech Republic
Spectrometry of linear energy transfer with track etched detectors in carbon ion beams, MONO and SOBP
Sofia Rollet, Austria
Microdosimetric assessment of the biological quality of a therapeutic proton beam: comparison between
Anthony Waker, Canada
Spectroscopic dosimetry with a Tissue Equivalent Proportional Counter for in vivo neutron activation facility
Akram Mohammadi, Japan
Influence of voxel size on specific absorbed fractions in a mouse voxel phantom for photons and electrons
Thomas Friedrich, Germany
Impact of tissue type and effect level on RBE
Ivan Petrovic, Serbia
Interpretation of radiobiological results obtained after proton and carbon irradiations of melanoma cells using
Effective Dose Determination for Astronauts Using the MATROSHKA Experiment
13.00 Lunch at the “Hotel San Marco”
14.30-18.00 Social Tour
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Thursday, October 29, 2009
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8.15-9.15 Refresher Course:
Lennart Lindborg, Sweden
Microdosimetry and radiation quality determinations in medicine and
radiation protection
9.15-10.30 Session XI – Progress in Experimental Microdosimetry
Stefano Agosteo, Italy (invited)
Silicon microdosimetry
Yigal Horowitz, Israel
Thermoluminescence solid state nanodosimetry – The peak 5A/5 dosimeter
Thermoluminescence solid state nanodosimetry – The peak 5A/5 dosimeter
Vladimir Bashkirov, USA
Ion Time Projection Chamber for precise imaging of ionizing particle track structure
Ion Time Projection Chamber for precise imaging of ionizing particle track structure
Stanislaw Pszona, Polonia
Single track nanodosimetry – from Track Ion Counter to Jet Counter
Single track nanodosimetry – from Track Ion Counter to Jet Counter
10.30 Coffee-Break
11.00-13.00 Session XII – (continuation of) Progress in Experimental Microdosimetry
Delia Perez-Nunez, USA
Replacement Tissue Equivalent Proportional Counter for the International Space Station
Replacement Tissue Equivalent Proportional Counter for the International Space Station
Shiuchi Tsuda, Japan
Microdosimetry for heavy ion beams using a Wall-Less Tissue Equivalent Proportional Counter
Katerina Brabcova, Czech Republic
Spectrometry of linear energy transfer with track etched detectors in carbon ion beams, MONO and SOBP
Sofia Rollet, Austria
Microdosimetric assessment of the biological quality of a therapeutic proton beam: comparison between
numerical simulation and experimental measurements
Anthony Waker, Canada
Spectroscopic dosimetry with a Tissue Equivalent Proportional Counter for in vivo neutron activation facility
Akram Mohammadi, Japan
Influence of voxel size on specific absorbed fractions in a mouse voxel phantom for photons and electrons
13.00 Lunch at the “Hotel San Marco”
14.30-16.00 Session XIII - Particle Radiotherapy
André Wambersie, Belgium (invited)
Isoeffect-dose: a concept for biological weighting of absorbed dose in
proton and heavier ion therapy
Thomas Friedrich, Germany
Impact of tissue type and effect level on RBE
Ivan Petrovic, Serbia
Interpretation of radiobiological results obtained after proton and carbon irradiations of melanoma cells using
numerical simulations with GEANT4 code
Francesca Ballarini, Italy
From radiation-induced chromosome damage to cell death: modelling basic mechanisms and applications to
From radiation-induced chromosome damage to cell death: modelling basic mechanisms and applications to
Boron Neutron Capture Therapy
16.00 Coffee-Break
16.30-18.30 Session XIV - POSTER SESSION
20.30 Social Dinner
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Friday, October 30, 2009
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8.15-9.15 Refresher Course:
Keith Baverstock, Finland
Can a systems approach help radiobiology?
9.15-10.45 Session XV – Systems Biology
William Morgan, USA (invited)
New Experimental Techniques for Radiation Systems Biology: The Pacific Northwest National Laboratory’s
Integrated Systems Biology Effort to Understand Cancer Risks from Low Doses of Ionizing Radiation
Francis A. Cucinotta, USA (invited)
Biophysics Model of the ATM Signal Transduction Pathway
Gastone Castellani, Italy
Systems Biology and dynamics of ionizing radiation response by multiscale analysis of gene
Systems Biology and dynamics of ionizing radiation response by multiscale analysis of gene
expression measurements.
Pavel Kundrat, Germany
Modelling of intercellular induction of apoptosis in oncogenic transformed cells and radiation effects on the
Modelling of intercellular induction of apoptosis in oncogenic transformed cells and radiation effects on the
phenomenon
10.45 Coffee-Break
11.15-13.30 Session XVI – Ongoing Research Initiatives and Open Questions
Mary Helen Barcellos-Hoff, USA
U.S. Department of Energy Low Dose Program
Mauro Belli, Italy
MELODI – the "Multidisciplinary European LOw Dose Initiative"
Ohtsura Niwa, Japan (to be confrmed)
Japan Low dose research initiative
Guenther Reitz, Germany
ICRP “Task Group 67” Report: Radiation Protection in Space
Andrea Ottolenghi, Italy
The risks of healthy tissues from the use of existing and emerging techniques for radiation
The risks of healthy tissues from the use of existing and emerging techniques for radiation
therapy
Panel Discussion :
Do non-targeted effects impact the relation between Microdosimetry and Risk?
Chair : Dudley T. Goodhead, UK
Discussants: (to be confirmed)
Symposium Closure
13.30 Lunch at the “Hotel San Marco”
