LEAPS Meets Life Sciences Conference

Session

Life Sciences Outlook

18 May 2023, 16:15

Hotel Hermitage, La Biodola Bay, Elba Island, Italy

182. Integrative Biology to tackle mitochondrial respiration in Alzheimer’s pathogenesis

Montserrat Soler Lopez (ESRF)

18/05/2023, 16:15

Oral

Respiratory complexes located in the internal membranes of our mitochondria are true macromolecular batteries: they couple the flow of electrons through clusters of metals and cofactors with a transfer of protons to create a gradient that provides the energy necessary for the ATP production and therefore to the nourishment of essential life processes. The first complex in the respiratory...

276. Cryo-trapped atomic resolution single crystal structures combined with time-resolved serial crystallography to explore enzyme mechanisms

Arwen Pearson (Universität Hamburg / CFEL), Ashwin Chari (MPI for Multidisciplinary Sciences, Göttingen)

18/05/2023, 16:45

Oral

Modern methods in Structural Biology aim to provide detailed insights into how proteins are able to catalyse and control chemical reactions. This requires understanding the role of the conformational dynamics of proteins in the regulation of enzyme catalysis, for example by allosteric phenomena. In recent years, time-resolved (TR) X-ray crystallography and structural enzymology have been...

214. Time-resolved serial crystallography studies of conformational changes in cytochrome c oxidase

Richard Neutze

18/05/2023, 17:15

Oral

Time-resolved X-ray crystallography allows time-dependent structural changes to be visualized as they evolve within protein crystals and can yield unique structural insights into the course of a biochemical reaction (1). Serial crystallography (2) is now routinely used for time-resolved X-ray diffraction studies of macromolecules at X-ray free electron laser and synchrotron radiation...

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Oral

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