Name: LEAPS Meets Life Sciences Conference
Start: 2023-05-14T17:00:00+02:00
End: 2023-05-19T07:30:00+02:00
Location: Hotel Hermitage, La Biodola Bay, Elba Island, Italy

LEAPS Meets Life Sciences Conference

from Sunday, May 14, 2023 (5:00 PM) to Friday, May 19, 2023 (7:30 AM)

Monday, May 8, 2023
Tuesday, May 9, 2023
Wednesday, May 10, 2023
Thursday, May 11, 2023
Friday, May 12, 2023
Saturday, May 13, 2023
Sunday, May 14, 2023

5:00 PM REGISTRATION
REGISTRATION
5:00 PM - 7:30 PM

7:30 PM Welcome Cocktail
Welcome Cocktail
7:30 PM - 8:30 PM

8:30 PM Dinner
Dinner
8:30 PM - 10:30 PM

Monday, May 15, 2023
8:45 AM Welcome to LEAPS Meets Life Sciences Conference - Caterina Biscari (Chair LEAPS Conference 2023)
Welcome to LEAPS Meets Life Sciences Conference
- Caterina Biscari (Chair LEAPS Conference 2023)
8:45 AM - 9:15 AM
9:15 AM Block 1
Block 1
9:15 AM - 10:15 AM
Contributions

9:15 AM Tutorial 1: Metagenomics: The key to new biology for basic protein research and application - Oded Beja (The Louis and Lyra Richmond Chair in Life Sciences, Faculty of Biology, Technion - Israel Institute of Technology, Haifa 3200003, Israel)
10:15 AM Coffee Break
Coffee Break
10:15 AM - 10:45 AM
10:45 AM Block 2
Block 2
10:45 AM - 11:15 AM
Contributions

10:45 AM Novel Biology Research at Paul Scherrer Institute - Gebhard F.X. Schertler (Paul Scherrer Institute, Switzerland)
11:15 AM Block 1
Block 1
11:15 AM - 12:00 PM
Contributions

11:15 AM Keynote 1: Serial diffraction of macromolecular systems - Henry Chapman (Center for Free-Electron Laser Science, DESY and University of Hamburg, Germany)
12:00 PM

12:00 PM - 12:15 PM
12:15 PM Poster talk
Poster talk
12:15 PM - 12:30 PM
Contributions

12:15 PM Gatekeepers of Prolyl-4-Hydroxylase 2 and mechanistic studies - Giorgia Fiorini
12:30 PM Lunch
Lunch
12:30 PM - 4:00 PM
4:00 PM Block 2
Block 2
4:00 PM - 5:30 PM
Contributions

4:00 PM Tutorial 2: The impact of artificial intelligence (AI) and computer simulations on biomolecular research - Jana Selent (Research Group on Biomedical Informatics, Hospital del Mar Medical Research Institute & Pompeu Fabra University, Barcelona, Spain)

5:00 PM Piz Daint on Alps: a modern day view of extreme computing and data in science - Thomas Schulthess (CSCS - Swiss National Supercomputing Centre)
5:30 PM

5:30 PM - 6:45 PM
6:45 PM Block 3
Block 3
6:45 PM - 7:15 PM
Contributions

6:45 PM Toward three-dimensional structure using X-ray free-electron laser - Florence Tama (RIKEN Center for Computational Science)
7:15 PM Block 1
Block 1
7:15 PM - 8:30 PM
Contributions

7:15 PM Keynote 2: Microsecond time-resolved cryo-electron microscopy - Ulrich Lorenz (Ecole Polytechnique Fédérale de Lausanne (EPFL), Switzerland)

8:00 PM New opportunities for time-resolved serial crystallography at the new ID29 from the ESRF extremely brilliant source - Julien Orlans (ESRF)
8:30 PM Dinner
Dinner
8:30 PM - 10:30 PM
Tuesday, May 16, 2023
8:45 AM Block 2
Block 2
8:45 AM - 10:15 AM
Contributions

8:45 AM Tutorial 3: The XFEL Hub at Diamond – enabling dynamic structural biology experiments locally & globally - Allen Orville (Diamond Light Source, U.K.)

9:45 AM Ultrafast dynamics of visual rhodopsin using an X-ray free electron laser - Valerie Panneels (Paul Scherrer Institute)
10:15 AM Coffee Break
Coffee Break
10:15 AM - 10:45 AM
10:45 AM Block 3
Block 3
10:45 AM - 12:00 PM
Contributions

10:45 AM Structure ensemble determination from ultrashort pulse single molecule X-ray scattering: a Bayesian approach - Helmut Grubmüller (Max Planck Institute for Multidisciplinary Sciences)

11:15 AM Keynote 3: Order from Disorder: Towards molecular architecture of the muscle Z-disk assembly by integrative structural biology - Kristina Djinovic Carugo (European Molecular Biology Laboratory (EMBL) Grenoble, 71 Avenue des Martyrs, 38000 Grenoble, France; Department of Structural and Computational Biology, Max Perutz Labs, University of Vienna, Campus Vienna Biocenter 5, 1030 Vienna, Austria)
12:00 PM Lunch
Lunch
12:00 PM - 1:00 PM

1:00 PM Excursion
Excursion
1:00 PM - 4:45 PM

4:45 PM

4:45 PM - 5:00 PM
5:00 PM Poster talk
Poster talk
5:00 PM - 5:15 PM
Contributions

5:00 PM X-ray structural studies of ba3-type cytochrome c oxidase - Doris Zoric
5:15 PM Block 1
Block 1
5:15 PM - 6:15 PM
Contributions

5:15 PM Tutorial 4: Advanced X-ray imaging: from the nanoscale at synchrotrons to clinical applications in hospitals - Marco Stampanoni (Paul Scherrer Institute and ETH Zürich)
6:15 PM Coffee Break
Coffee Break
6:15 PM - 6:45 PM
6:45 PM Block 2
Block 2
6:45 PM - 8:30 PM
Contributions

6:45 PM Keynote 4: Multi-scale in situ structural biology in the UK national cryoEM facility eBIC - Peijun Zhang (Diamond Light Source/ University of Oxford)

7:30 PM Human lung virtual histology by multi-scale X-ray phase-contrast computed tomography - Jakob Reichmann (University of Göttingen)

8:00 PM Multilevel X-ray imaging approach to assess the sequential evolution of multi-organ damage in neurodegenerative diseases - Francesca Palermo (Institute of Nanotechnology - CNR)
8:30 PM Dinner
Dinner
8:30 PM - 10:30 PM
Wednesday, May 17, 2023
8:45 AM Block 1
Block 1
8:45 AM - 10:30 AM
Contributions

8:45 AM Keynote 5: Structure-guided approaches to malaria vaccines - Matt Higgins

9:30 AM Ambient-temperature serial femtosecond crystallography studies of bacterial ribosome antibiotic complexes - Hasan Demirci (Koç University, Istanbul, Turkey)

10:00 AM Large scale imaging of neuronal networks of the brain - Adrian Wanner
10:30 AM Coffee Break
Coffee Break
10:30 AM - 11:00 AM
11:00 AM Block 2
Block 2
11:00 AM - 12:30 PM
Contributions

11:00 AM Molecular mechanisms of tau filament formation - Sofia Lovestam

11:30 AM Integrative structural biology applied to virus infection - Winfried Weissenhorn (University Grenoble Alpes)

12:00 PM Pandemic responses and the impact of infrastructure and technology on structural studies - Dave Stuart (Dave Stuart Strubi, Department of Medicine, University of Oxford and Diamond Light Source, U.K.)
12:30 PM Lunch
Lunch
12:30 PM - 4:00 PM
4:00 PM Poster talks
Poster talks
4:00 PM - 4:45 PM
Contributions

4:00 PM The First Ambient Temperature Structure of Large Ribosomal Subunit from Thermus Thermophilus - Bilge Tosun Cahine Kulakman (Koc University)

4:15 PM Selecting Synthetic Photoswitches for Time-Resolved Serial Crystallography of the Human A2A Receptor - Hannah Glover (Paul Scherrer Institut)

4:30 PM JINXED: Just in Time Crystallization for Easy Structure Determination of Biological Macromolecules - Alessandra Henkel (Center for Free-Electron Laser Science, DESY)
4:45 PM Block 1
Block 1
4:45 PM - 5:30 PM
Contributions

4:45 PM Keynote 6: Structure-based drug discovery in biotech and pharma - Michael Hennig (leadXpro AG, Park Innovaare, 5234 Villigen, Switzerland)
5:30 PM

5:30 PM - 6:45 PM
6:45 PM Block 2
Block 2
6:45 PM - 8:15 PM
Contributions

6:45 PM Structure analyze HIV-1 Gag-IP6 complexes using ambient-temperature X-ray crystallography and in-solution Small-angle X-ray scattering. - Nurettin Tokay

7:15 PM Photopharmacology: Where light and molecules meet crystallography - Amadeu Llebaria (MCS, Laboratory of Medicinal Chemistry & Synthesis, Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), 08034 Barcelona, Spain)

7:45 PM Watching the release of a photopharmacological drug from its target using SLS and SwissFEL - Jörg Standfuss (Division of Biology and Chemistry, Paul Scherrer Institut, 5232 Villigen, Switzerland)
8:15 PM Social Dinner and Dance
Social Dinner and Dance
8:15 PM - 10:30 PM
Thursday, May 18, 2023
8:45 AM Block 3
Block 3
8:45 AM - 10:00 AM
Contributions

8:45 AM Keynote 7: Four-dimensional structural analysis of membrane proteins and its application to drug discovery - So Iwata (Graduate School of Medicine, Kyoto University and RIKEN SPring-8 Center)

9:30 AM Detuning of the ribosome conformational landscape promotes antibiotic resistance and collateral sensitivity - Guillermo Montoya (NNF-CPR University of Copenhagen) Pablo Mesa (NNF-CPR)
10:00 AM Block 1
Block 1
10:00 AM - 10:30 AM
Contributions

10:00 AM LEAPS and the future of life sciences at large facilities - Jean Susini (Synchrotron SOLEIL)
10:30 AM Coffee Break
Coffee Break
10:30 AM - 11:00 AM
11:00 AM Block 2
Block 2
11:00 AM - 11:30 AM
Contributions

11:00 AM Light sources serving life and other sciences: A view from the US - Roger Falcone (University of California, Berkeley)

11:15 AM Synchrotrons for biology, examples from the US - Greg Hura (Lawrence Berkeley National Laboratory, U.S.)
11:30 AM Panel Discussion
Panel Discussion
11:30 AM - 12:30 PM

12:30 PM Lunch
Lunch
12:30 PM - 4:00 PM
4:00 PM Poster talk
Poster talk
4:00 PM - 4:15 PM
Contributions

4:00 PM Studying structural dynamics in biology at SLAC National Accelerator Laboratory - Sandra Mous (SLAC National Accelerator Laboratory)
4:15 PM Block 1
Block 1
4:15 PM - 5:45 PM
Contributions

4:15 PM Integrative Biology to tackle mitochondrial respiration in Alzheimer’s pathogenesis - Montserrat Soler Lopez (ESRF)

4:45 PM Cryo-trapped atomic resolution single crystal structures combined with time-resolved serial crystallography to explore enzyme mechanisms - Arwen Pearson (Universität Hamburg / CFEL) Ashwin Chari (MPI for Multidisciplinary Sciences, Göttingen)

5:15 PM Time-resolved serial crystallography studies of conformational changes in cytochrome c oxidase - Richard Neutze
5:45 PM Discussion
Discussion
5:45 PM - 6:15 PM

6:15 PM Coffee Break
Coffee Break
6:15 PM - 6:45 PM

6:45 PM Summary and outlook
Summary and outlook
6:45 PM - 7:45 PM

7:45 PM Conclusion
Conclusion
7:45 PM - 8:15 PM

8:15 PM Social Aperitivo
Social Aperitivo
8:15 PM - 9:00 PM

9:00 PM Farewell Dinner
Farewell Dinner
9:00 PM - 11:00 PM
Friday, May 19, 2023

7:00 AM Bus Depature
Bus Depature
7:00 AM - 7:30 AM

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