May 14 – 19, 2023
Hotel Hermitage, La Biodola Bay, Elba Island, Italy
Europe/Rome timezone

Keynote 4: Multi-scale in situ structural biology in the UK national cryoEM facility eBIC

May 16, 2023, 6:45 PM
45m
Hotel Hermitage, La Biodola Bay, Elba Island, Italy

Hotel Hermitage, La Biodola Bay, Elba Island, Italy

Biodola Bay 57037 Portoferraio (LI) Isola d’Elba - Italy
Oral Bioimaging

Speaker

Peijun Zhang (Diamond Light Source/ University of Oxford)

Description

The electron Bio-Imaging Centre (eBIC) is a UK national cryoEM facility located at the UK synchrotron Diamond Light Source. eBIC provides UK and international scientists with state-of-the-art experimental equipment, expertise, and training, in the field of cryo-electron microscopy, for single particle analysis, electron tomography, electron diffraction, and correlative microscopy. eBIC also develops cutting-edge technology with in-house research program, output of which further benefits our users and beyond. The location of eBIC enables scientists to combine their techniques with many of the other cutting-edge approaches that Diamond offers. In this presentation, I will demonstrate the power of emerging in situ structural biology and methods development towards high resolution structures of protein complexes in the most native cellular context. I will also showcase the integration of multi-scale imaging modalities encompassing cryo-electron tomography, soft x-ray imaging and cryoFIB/SEM volume imaging to investigate virus infections in cells.

Select Topic 1 Modern Methods in Structural Biology and Dynamics
Select Topic 2 Bioimaging

Primary author

Peijun Zhang (Diamond Light Source/ University of Oxford)

Presentation materials