Camilla Giaccaglia
(Laboratoire d'Optique Appliquée, CNRS, Ecole Polytechnique, Institute Polytechnique de Paris, 921120 Palaiseau, France)
Laser-Plasma Accelerators (LPAs) are emerging as versatile sources for generating ultra-high dose rate beams for radiotherapy research. With ultrashort pulse durations from femtoseconds to nanoseconds, they enable instantaneous dose rates exceeding 10⁹ Gy/s. Their acceleration gradients, surpassing 100 GV/m, allow for the generation of Very High Energy Electron (VHEE) beams (>50 MeV) in a compact setup, overcoming the limitations of conventional linear accelerators. These beams are investigated as a novel radiotherapy modality, offering clinical advantages over photons and protons.
We characterized the LPA at the Laboratoire d’Optique Appliquée, optimizing acceleration conditions for stable VHEE beam delivery (50-100 MeV, 350 mGy/shot, 10 Gy/min average dose rate). To assess the biological effects of LPA-driven VHEE beams, we performed a comparative study against Conventionally Accelerated Electrons (CAE, 7 MeV) across multiple assays: i) in vitro survival of U87 human glioblastoma cells, ii) ex vivo quantification of dividing cells in mouse lung slices, and iii) in vivo growth monitoring of zebrafish embryos post-irradiation.
Results demonstrated that LPA-driven VHEE beams exhibit comparable antitumoral efficacy and toxicity to CAE, supporting their feasibility for radiobiological applications. This work establishes laser-driven VHEE beams as a promising platform for preclinical studies and a viable alternative to conventional electron therapy.
Camilla Giaccaglia
(Laboratoire d'Optique Appliquée, CNRS, Ecole Polytechnique, Institute Polytechnique de Paris, 921120 Palaiseau, France)
Alessandro Flacco
(Laboratoire d'Optique Appliquée, CNRS, Ecole Polytechnique, Institute Polytechnique de Paris, 921120 Palaiseau, France)
Amar Tafzi
(Laboratoire d'Optique Appliquée, CNRS, Ecole Polytechnique, Institute Polytechnique de Paris, 921120 Palaiseau, France)
Chaitanya Varma
(Laboratoire d'Optique Appliquée, CNRS, Ecole Polytechnique, Institute Polytechnique de Paris, 921120 Palaiseau, France)
Charles Fouillade
(Institut Curie, Inserm U1021, UMR 3347, University Paris-Saclay, PSL Research University, 91405 Orsay Cedex, France)
Emilie Bayart
(Laboratoire d'Optique Appliquée, CNRS, Ecole Polytechnique, Institute Polytechnique de Paris, 921120 Palaiseau, France)
Isabelle Lamarre
(Laboratory for Optics and Biosciences, Ecole Polytechnique, CNRS, INSERM, 91128 Palaiseau Cedex, France)
Jean-philippe Goddet
(Laboratoire d'Optique Appliquée, CNRS, Ecole Polytechnique, Institute Polytechnique de Paris, 921120 Palaiseau, France)
Julien Gautier
(Laboratoire d'Optique Appliquée, CNRS, Ecole Polytechnique, Institute Polytechnique de Paris, 921120 Palaiseau, France)
Maxime Dubail
(Institut Curie, Inserm U1021, UMR 3347, University Paris-Saclay, PSL Research University, 91405 Orsay Cedex, France)
Sophie Heinrich
(Institut Curie, Inserm U1021, UMR 3347, University Paris-Saclay, PSL Research University, 91405 Orsay Cedex, France)
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