Synchrotron radiation and free electron laser facilities are by nature large-scale multidisciplinary research infrastructures, as exemplified by LEAPS partners which offer a comprehensive and unique portfolio of instruments, methods, and techniques, to support a wide and diverse range of applications, from physics, chemistry, engineering to biology and medicine.
In this context, the Life...
The capabilities of light source user facilities continually expand. High brightness and high time resolution are two technical advances that are popular globally. In the U.S., investments are being made across many facilities, in these and other areas, to support the need for new imaging and dynamic studies. I will provide a view of the strategy behind, and implementation of, these advances.
Synchrotrons have a foundational imaging role in the bioscience area. Hundreds of laboratories across the US depend on synchrotrons for their research. An exemplary, outstanding and under-appreciated outcome from the past decade is the machine learning (ML) based protein structure prediction. Training the ML relied on the imaging of thousands of structures generated by a large crystallography...
The Linac Coherent Light Source (LCLS) at SLAC National Accelerator Laboratory has partnered with the U.S. National Institute of General Medical Sciences (NIGMS) to create the Center for Structural Dynamics in Biology (SDB). The center serves the biomedical research community by developing tools and technologies for studying protein dynamics at LCLS and the Stanford Synchrotron Radiation...
