5-10 November 2017
Venice (Venezia), Italy
Europe/Rome timezone
Scientific Programme
  [for a printable pdf copy, please click Here]

Sunday, November 5, 2017                                     

15.00-18.00  Registration at the  “Congress Centre” –   "Cultural Center Don Orione Artigianelli", Dorsoduro-Zattere, Venice (Venezia), Italy
                    Registration Desk will remain open from Monday Nov.6 to Friday Nov.10  throughout the Symposium Scientific Sessions.

17.30-19.00  Opening Cerimony:
Opening Addresses
Opening lecture -  “H.H. Rossi Lecture”:
Hans-Georg Menzel, Germany and ICRU:
The complexity of quantities in radiation dosimetry. The issue of radiation quality [50min]
19.30           Welcome Dinner - at the “San Trovaso Restaurant”, Dorsoduro-Zattere, Venice

Monday, November 6, 2017                                    

8.30 - 9.30    Refresher Course

Chair : M. Davidkova, Czech Rep.

Michael Dingfelder, USA (Invited Speaker)
Track structure simulations: from cross section to nano-particles  [50min]


9.30 - 11:00  Session I – Physics and Chemistry of radiation tracks

Chair : D.T. Goodhead, UK

Werner Friedland, Germany (Invited Speaker)
Mechanistic modelling of subcellular and cellular radiation effects with PARTRAC [30min]
Caterina Monini,
NanOx, a new multiscale model to predict biological effects of ionizing radiation [20min]
Nicolas Tang,
France (Micros2017 award)
Simulation of early radiation-induced DNA damage on different types of cell nuclei [20min]
Fabiano Vasi
, Switzerland
A nanodosimetric based mechanistic cell survival model applied to charged particle survival curves [20min]

11:00 - 11:30          Coffee-Break

11.30 -13.00   Session II – DNA damage and repair / experiments and modelling
Chair : Y. Furusawa, Japan

George Iliakis, Germany (Invited Speaker)
Defined Biological Models of High LET Radiation Lesions [30min]
Reza Taleei, USA (RRS award)
Modeling DSB and SSB repair kinetics for DNA damage induced from particle therapy [20min]
Naoya Shikazono, Japan
Detection and mutagenic potential of clustered DNA lesions [20min]
Andris Abramenkovs, Sweden
Measuring DNA double strand breaks by flow cytometric analysis of DNA-PKcs phosphorylation [20min]

13.00           Lunch - at the “San Trovaso Restaurant”

14.30-16.30  Session III – Radiation Action/RBE and Radiation Quality
Chair: G. Iliakis, Germany

Kevin Prise, UK (Invited Speaker)
From DNA damage complexity to an RBE for protons, challenges in translation [30min]
Thomas Friedrich, Germany  [RRS award]
Unveiling coexisting spatial scales of radiation damage interaction and their relevance for the RBE [20min]
Mario Pietro Carante, Italy  [Micros2017 award]
Predicting biological effects along hadrontherapy dose profiles by the BIANCA biophysical model [20min]
Carsten Herskind, Germany
A model of radioresistance and cell survival curve shape based on cell-cycle progression and damage tolerance [20min]
Sofia Barbieri, Italy  [Micros2017 award]
Mechanistic study of low- and high-LET radiation induced DNA damages: benchmarking Monte Carlo simulations with experimental results [20min]

16:30 - 17:00          Coffee-Break

16:30 -18:00 Session IV – Systems Biology in Radiation Effects

Chair : M. H. Barcellos-Hoff, USA

Marc S. Mendonca, USA (Invited Speaker)
Metabolic Reprogramming Increases Radiation-induced Cell Killing in Pancreatic Cancer  [30min]
Maddalena Mognato, Italy  
MiRNA-mediated modulation of DNA double-strand repair genes in γ-irradiated human cancer cells [20min]
Andrea Ottolenghi, Italy
What roles for track structure and microdosimetry in the era of omics, systems biology and holistic approaches? [20min]

Pavel Kundrát, Germany  
Mechanistic modelling predicts anti-carcinogenic radiation effects on intercellular signalling in vitro turn pro-carcinogenic in vivo [20min]


Tuesday, November 7, 2017                                   

8.30-9.30      Refresher Course

Chair : M. S. Mendonca, USA

Jean-Pierre Pouget, France (Invited Speaker)
Role of oxidative mechanisms in targeted and non-targeted effect of radiation therapy

9.30- 10:45   Session V – Genomic instability, signalling, epigenetics effects

Chair : J-P. Pouget, France

Carmel Mothersill, Canada (Invited Speaker)
The role of secondary excitation decay and exosomes in generation of bystander effects  [30min]
Alisa Kobayashi, Japan  [Micros2017 award]
Bystander WI38 normal lung fibroblast cells modulate double strand breaks repair of microbeam targeted A549 cells through gap junction intercellular communication [20min]
Gabriele Babini, Italy  [Micros2017 award]
Perturbed temporal dynamics of MIRNOME profiles of endothelial cells irradiated with low dose of gamma-rays [20min]


10.45 - 11:15          Coffee-Break

11.15-13.00  Session VI – Low-dose effects /non-linear mechanisms
Chair : C. Mothersill, Canada

Mary-Helen Barcellos-Hoff, USA (Invited Speaker)
The Contribution of Non-targeted Effects to Low-Dose Radiation Carcinogenesis: New insights on immune system dysfunction [30min]
Yuya Hattori, Japan
A mathematical model of enhanced DNA repair effect on cell survival in radiation-induced adaptive responses [20min]
Balázs Madas, Hungary
Computational modelling of low dose hyper-radiosensitivity applying the principle of minimizing mutation rate [20min]
Masatoshi Ukai, Japan
Novel analytical study for reaction intermediates in the primary radiation interaction of DNA using a synchrotron radiation induced luminescence spectroscopy [20min]

13.00           Lunch  - at the “San Trovaso Restaurant”

14.30-16.00  Session VII – Auger Electrons and Internal Emitters/Nanoparticles

Chair : M. Dingfelder, USA

Sandrine Lacombe, France (Invited Speaker)
Effects of nanoparticles combined with medical ion radiation [30min]

Hilary Byrne, Australia  [RRS award]
Impact of nanoparticle clustering on energy deposition, ionisations and dose enhancement [20min]
Tobias Dressel, Germany
An algorithm to determine the nanodosimetric impact of gold nanoparticle concentrations on cell models [20min]
Nora Hocine, France
Distribution of Sr-90 in the bone and cellular dosimetry using MCNPX and PENELOPE Monte Carlo codes [20min]


16.00 - 16:30          Coffee-Break


16:30-18:30  Session VIII - POSTER SESSION (Presentation of the posters with odd ID numbers)


Wednesday, November 8, 2017                              

8.30-9.30      Refresher Course

Chair : V. Bashkirov, USA

Anatoly Rosenfeld, Australia (Invited Speaker)
Dosimetry of synchrotron micro-and charged particle mini-therapeutic beams [50min]

9.30 - 11:00  Session IX – Space Radiation Research
Chair : M. Hill, UK

Francis A. Cucinotta, USA (Invited Speaker)
Non-Target Effects Alter Space Radiation Risk Dependence on Mission Duration [30min]
Yoshiya Furusawa,
Dose-rate and cell killing sensitivity of high-LET Ion Beam [20min]
Alessio Parisi
,  Belgium
Microdosimetric modeling of the relative efficiency of thermoluminescent detectors exposed to charged particles [20min]
Giorgio Baiocco
, Italy
Innovative solutions for personal radiation shielding in space: the PERSEO project [20min]

11.00 - 11.30          Coffee-Break


11.30 - 13.00  Session X – Neuro-Radiobiology / CNS effects

Chair : B. Stenerlow, Sweden

Francis A. Cucinotta, USA (Invited Speaker)
Track Structure and the Degradation of Neuron Morphology in Hadron Therapy and Space Radiation Exposures [30min]
Francesco Tommasino, Italy    [SIRR award]
A new facility for proton beam irradiation at the Trento proton therapy centre [20min]
Charbel Koumeir, France
The radiobiological platform at cyclotron Arronax [20min]
Martin Sefl, Czech Republic  [Micros2017 award]
GEANT4-Based dosimetry of biological samples in microtubes [20min]

13:00             Lunch - at the “San Trovaso Restaurant”

14:30 - 19.00          Social Tour


Thursday, November 9, 2017                                  

8.30-9.30      Refresher Course

Chair : M. Eidemuller, Germany

David Brenner, USA  (Invited Speaker)
Mechanistic models for radiation  carcinogenesis [50min]



9.30-10.45    Session XI - Experimental and Computational Micro- and Nano-dosimetry

Chair : A. Rosenfeld, Australia

Chiara La Tessa, Italy   (Invited Speaker)
The role of microdosimetry in hadrontherapy and space radioprotection  [30min]
Davide Bortot, Italy
A novel TEPC for microdosimetry at nanometric level: response against 62 AMeV He-4 ions [20min]
Jasper Kouwenberg, Netherland
Experimental Alpha Microdosimetry using Fluorescent Nuclear Track Detectors [20min]

10.45 - 11.15          Coffee-Break

11.15 -13.00  Session XII Experimental and Computational Micro- and Nano-dosimetry  (continuation)

Chair : A. Waker, Canada

Carmen Villagrasa, France (Invited Speaker)
Assessing the contribution of cross-sections to the uncertainty of MonteCarlo calculations in micro- and nano-dosimetry [30min]
Fernanda Villegas, Sweden
The role of cavity size in microdosimetric specific energy distributions and linear-quadratic parameterization of cell survival [20min]
Marcin Pietrzak, Poland
On the two modes of nanodosimetric experiments - exercise with JET counter [20min]
Anna Selva, Italy
Nanodosimetry as a bridge between physics and radiobiology [20min]


13.00           Lunch - at the “San Trovaso Restaurant”

14.30-16.00  Session XIII –  X-rays and Particles’ Micro- and Mini-beams: biological and clinical applications

Chair : D. Brenner, USA

Peter O’Neill, UK  (Invited Speaker)
Tracking the fate of cellular DNA damage in real-time following microbeam irradiation with ultrasoft X-rays [30min]
Radu Vasilache, Romania
The development of a novel array detectors for overcoming the dosimetry challenges of measuring in very short pulsed charged particle beams - the ELIDOSE project [20min]
Matthias Würl, Germany
Development of two prototype spectrometers for laser-accelerated proton bunches [20min]
Judith N. Rivera, USA  [RRS award]                
Nano-scintillanting fiber optic dosimetry system for real-time microbeam radiation peak dose measurement [20min]

16.00-16.30  Coffee-Break

16.30-18.30  Session XIV - POSTER SESSION (Presentation of the posters with even ID numbers)

20.30           Social Dinner  


Friday, November 10, 2017                                     

8.30-9.30      Refresher Course

Chair : W. Friedland, Germany

Emanuele Scifoni, Italy  (Invited Speaker)
Biologically oriented treatment planning  [50min]

9.30 - 10.45  Session XV – Risk assessment

Chair : H.G. Menzel, Germany

Dudley T. Goodhead, UK (Invited Speaker)
Biological effectiveness of lower-energy photons for cancer risk, with reference to the new NCRP report [30min]
Markus Eidemüller, Germany
PASSOS: methodology and software to assess long-term health risks after breast cancer therapy and heart diagnostic procedures [20min]
Marie Davidkova, Czech Republic
Properties of Nuclear Track Emulsions and their use in Neutron Dosimetry [20min]

10.45 - 11:15          Coffee-Break

11.30 -13.20           Session XVI – Advances in Radiotherapy including Hadrontherapy, BNCT, Radio-immunotherapy
Chair : M. Waligorski, Poland

Leszek Grzanka, Poland
The confusing role of LET in radiation therapy - will microdosimetry help ? [20min]
Tatsuhiko Sato, Japan
Application of stochastic microdosimetric kinetic model to boron neutron capture therapy [20min]
Eric Diffenderfer, USA
A time-resolved mini-TEPC measurement and data acquisition system for therapeutic proton beams - development and validation [20min]
Giulio Magrin, Austria
Ion-beam therapy and microdosimetry: effects of detector shapes and materials [20min]
Michal Pomorski, France
Single Crystal CVD Diamond Membrane Microdosimeters  for Hadron Therapy [20min]
Marcello Serra,  Italy
Characterization of a small FOV portable GC: MediPROBE [20min]


13.20           Symposium Closure

13.30   Lunch - at the “San Trovaso Restaurant”


15.00   Satellite Event
S.I.R.R. Annual General Meeting