MICROS 2017
Scientific Programme
Scientific Programme
Sunday, November 5, 2017 |
15.00-18.00 Registration at the “Congress Centre” – "Cultural Center Don Orione Artigianelli", Dorsoduro-Zattere, Venice (Venezia), Italy
Registration Desk will remain open from Monday Nov.6 to Friday Nov.10 throughout the Symposium Scientific Sessions.
17.30-19.00 Opening Cerimony:
Opening Addresses
Opening lecture - “H.H. Rossi Lecture”:
Hans-Georg Menzel, Germany and ICRU:
The complexity of quantities in radiation dosimetry. The issue of radiation quality [50min]
Hans-Georg Menzel, Germany and ICRU:
The complexity of quantities in radiation dosimetry. The issue of radiation quality [50min]
19.30 Welcome Dinner - at the “San Trovaso Restaurant”, Dorsoduro-Zattere, Venice
Monday, November 6, 2017 |
8.30 - 9.30 Refresher Course
Chair : M. Davidkova, Czech Rep.
Michael Dingfelder, USA (Invited Speaker)
Track structure simulations: from cross section to nano-particles [50min]
Track structure simulations: from cross section to nano-particles [50min]
9.30 - 11:00 Session I – Physics and Chemistry of radiation tracks
Chair : D.T. Goodhead, UK
Werner Friedland, Germany (Invited Speaker)
Mechanistic modelling of subcellular and cellular radiation effects with PARTRAC [30min]
Caterina Monini, France
NanOx, a new multiscale model to predict biological effects of ionizing radiation [20min]
Nicolas Tang, France (Micros2017 award)
Simulation of early radiation-induced DNA damage on different types of cell nuclei [20min]
Fabiano Vasi, Switzerland
A nanodosimetric based mechanistic cell survival model applied to charged particle survival curves [20min]
11:00 - 11:30 Coffee-Break
11.30 -13.00 Session II – DNA damage and repair / experiments and modelling
Chair : Y. Furusawa, Japan
George Iliakis, Germany (Invited Speaker)
Defined Biological Models of High LET Radiation Lesions [30min]
Reza Taleei, USA (RRS award)
Modeling DSB and SSB repair kinetics for DNA damage induced from particle therapy [20min]
Naoya Shikazono, Japan
Detection and mutagenic potential of clustered DNA lesions [20min]
Andris Abramenkovs, Sweden
Measuring DNA double strand breaks by flow cytometric analysis of DNA-PKcs phosphorylation [20min]
13.00 Lunch - at the “San Trovaso Restaurant”George Iliakis, Germany (Invited Speaker)
Defined Biological Models of High LET Radiation Lesions [30min]
Reza Taleei, USA (RRS award)
Modeling DSB and SSB repair kinetics for DNA damage induced from particle therapy [20min]
Naoya Shikazono, Japan
Detection and mutagenic potential of clustered DNA lesions [20min]
Andris Abramenkovs, Sweden
Measuring DNA double strand breaks by flow cytometric analysis of DNA-PKcs phosphorylation [20min]
14.30-16.30 Session III – Radiation Action/RBE and Radiation Quality
Chair: G. Iliakis, Germany
Kevin Prise, UK (Invited Speaker)
From DNA damage complexity to an RBE for protons, challenges in translation [30min]
Thomas Friedrich, Germany [RRS award]
Unveiling coexisting spatial scales of radiation damage interaction and their relevance for the RBE [20min]
Mario Pietro Carante, Italy [Micros2017 award]
Predicting biological effects along hadrontherapy dose profiles by the BIANCA biophysical model [20min]
Carsten Herskind, Germany
A model of radioresistance and cell survival curve shape based on cell-cycle progression and damage tolerance [20min]
Sofia Barbieri, Italy [Micros2017 award]
Mechanistic study of low- and high-LET radiation induced DNA damages: benchmarking Monte Carlo simulations with experimental results [20min]
Kevin Prise, UK (Invited Speaker)
From DNA damage complexity to an RBE for protons, challenges in translation [30min]
Thomas Friedrich, Germany [RRS award]
Unveiling coexisting spatial scales of radiation damage interaction and their relevance for the RBE [20min]
Mario Pietro Carante, Italy [Micros2017 award]
Predicting biological effects along hadrontherapy dose profiles by the BIANCA biophysical model [20min]
Carsten Herskind, Germany
A model of radioresistance and cell survival curve shape based on cell-cycle progression and damage tolerance [20min]
Sofia Barbieri, Italy [Micros2017 award]
Mechanistic study of low- and high-LET radiation induced DNA damages: benchmarking Monte Carlo simulations with experimental results [20min]
16:30 - 17:00 Coffee-Break
16:30 -18:00 Session IV – Systems Biology in Radiation Effects
Chair : M. H. Barcellos-Hoff, USA
Marc S. Mendonca, USA (Invited Speaker)
Metabolic Reprogramming Increases Radiation-induced Cell Killing in Pancreatic Cancer [30min]
Maddalena Mognato, Italy
MiRNA-mediated modulation of DNA double-strand repair genes in γ-irradiated human cancer cells [20min]
Andrea Ottolenghi, Italy
What roles for track structure and microdosimetry in the era of omics, systems biology and holistic approaches? [20min]
Pavel Kundrát, Germany
Mechanistic modelling predicts anti-carcinogenic radiation effects on intercellular signalling in vitro turn pro-carcinogenic in vivo [20min]
Marc S. Mendonca, USA (Invited Speaker)
Metabolic Reprogramming Increases Radiation-induced Cell Killing in Pancreatic Cancer [30min]
Maddalena Mognato, Italy
MiRNA-mediated modulation of DNA double-strand repair genes in γ-irradiated human cancer cells [20min]
Andrea Ottolenghi, Italy
What roles for track structure and microdosimetry in the era of omics, systems biology and holistic approaches? [20min]
Pavel Kundrát, Germany
Mechanistic modelling predicts anti-carcinogenic radiation effects on intercellular signalling in vitro turn pro-carcinogenic in vivo [20min]
Tuesday, November 7, 2017 |
8.30-9.30 Refresher Course
Chair : M. S. Mendonca, USA
Jean-Pierre Pouget, France (Invited Speaker)
Role of oxidative mechanisms in targeted and non-targeted effect of radiation therapy
[50min]
9.30- 10:45 Session V – Genomic instability, signalling, epigenetics effects
Jean-Pierre Pouget, France (Invited Speaker)
Role of oxidative mechanisms in targeted and non-targeted effect of radiation therapy
[50min]
Chair : J-P. Pouget, France
Carmel Mothersill, Canada (Invited Speaker)
The role of secondary excitation decay and exosomes in generation of bystander effects [30min]
Alisa Kobayashi, Japan [Micros2017 award]
Bystander WI38 normal lung fibroblast cells modulate double strand breaks repair of microbeam targeted A549 cells through gap junction intercellular communication [20min]
Gabriele Babini, Italy [Micros2017 award]
Perturbed temporal dynamics of MIRNOME profiles of endothelial cells irradiated with low dose of gamma-rays [20min]
11.15-13.00 Session VI – Low-dose effects /non-linear mechanisms
Chair : C. Mothersill, Canada
Mary-Helen Barcellos-Hoff, USA (Invited Speaker)
The Contribution of Non-targeted Effects to Low-Dose Radiation Carcinogenesis: New insights on immune system dysfunction [30min]
Yuya Hattori, Japan
A mathematical model of enhanced DNA repair effect on cell survival in radiation-induced adaptive responses [20min]
Balázs Madas, Hungary
Computational modelling of low dose hyper-radiosensitivity applying the principle of minimizing mutation rate [20min]
Masatoshi Ukai, Japan
Novel analytical study for reaction intermediates in the primary radiation interaction of DNA using a synchrotron radiation induced luminescence spectroscopy [20min]
13.00 Lunch - at the “San Trovaso Restaurant”
14.30-16.00 Session VII – Auger Electrons and Internal Emitters/Nanoparticles
Chair : M. Dingfelder, USA
Sandrine Lacombe, France (Invited Speaker)
Effects of nanoparticles combined with medical ion radiation [30min]
Hilary Byrne, Australia [RRS award]
Impact of nanoparticle clustering on energy deposition, ionisations and dose enhancement [20min]
Tobias Dressel, Germany
An algorithm to determine the nanodosimetric impact of gold nanoparticle concentrations on cell models [20min]
Nora Hocine, France
Distribution of Sr-90 in the bone and cellular dosimetry using MCNPX and PENELOPE Monte Carlo codes [20min]
16.00 - 16:30 Coffee-BreakSandrine Lacombe, France (Invited Speaker)
Effects of nanoparticles combined with medical ion radiation [30min]
Hilary Byrne, Australia [RRS award]
Impact of nanoparticle clustering on energy deposition, ionisations and dose enhancement [20min]
Tobias Dressel, Germany
An algorithm to determine the nanodosimetric impact of gold nanoparticle concentrations on cell models [20min]
Nora Hocine, France
Distribution of Sr-90 in the bone and cellular dosimetry using MCNPX and PENELOPE Monte Carlo codes [20min]
16:30-18:30 Session VIII - POSTER SESSION (Presentation of the posters with odd ID numbers)
Wednesday, November 8, 2017 |
8.30-9.30 Refresher Course
Chair : V. Bashkirov, USA
Anatoly Rosenfeld, Australia (Invited Speaker)
Dosimetry of synchrotron micro-and charged particle mini-therapeutic beams [50min]
Anatoly Rosenfeld, Australia (Invited Speaker)
Dosimetry of synchrotron micro-and charged particle mini-therapeutic beams [50min]
9.30 - 11:00 Session IX – Space Radiation Research
Chair : M. Hill, UK
Francis A. Cucinotta, USA (Invited Speaker)
Non-Target Effects Alter Space Radiation Risk Dependence on Mission Duration [30min]
Yoshiya Furusawa, Japan
Dose-rate and cell killing sensitivity of high-LET Ion Beam [20min]
Alessio Parisi, Belgium
Microdosimetric modeling of the relative efficiency of thermoluminescent detectors exposed to charged particles [20min]
Giorgio Baiocco, Italy
Innovative solutions for personal radiation shielding in space: the PERSEO project [20min]
11.30 - 13.00 Session X – Neuro-Radiobiology / CNS effects
Chair : B. Stenerlow, Sweden
Francis A. Cucinotta, USA (Invited Speaker)
Track Structure and the Degradation of Neuron Morphology in Hadron Therapy and Space Radiation Exposures [30min]
Francesco Tommasino, Italy [SIRR award]
A new facility for proton beam irradiation at the Trento proton therapy centre [20min]
Charbel Koumeir, France
The radiobiological platform at cyclotron Arronax [20min]
Martin Sefl, Czech Republic [Micros2017 award]
GEANT4-Based dosimetry of biological samples in microtubes [20min]
13:00 Lunch - at the “San Trovaso Restaurant”
14:30 - 19.00 Social Tour
Thursday, November 9, 2017 |
8.30-9.30 Refresher Course
Chair : M. Eidemuller, Germany
David Brenner, USA (Invited Speaker)
Mechanistic models for radiation carcinogenesis [50min]
9.30-10.45 Session XI - Experimental and Computational Micro- and Nano-dosimetry
Chair : A. Rosenfeld, Australia
Chiara La Tessa, Italy (Invited Speaker)
The role of microdosimetry in hadrontherapy and space radioprotection [30min]
Davide Bortot, Italy
A novel TEPC for microdosimetry at nanometric level: response against 62 AMeV He-4 ions [20min]
Jasper Kouwenberg, Netherland
Experimental Alpha Microdosimetry using Fluorescent Nuclear Track Detectors [20min]
10.45 - 11.15 Coffee-Break
11.15 -13.00 Session XII – Experimental and Computational Micro- and Nano-dosimetry (continuation)
Chair : A. Waker, Canada
Carmen Villagrasa, France (Invited Speaker)
Assessing the contribution of cross-sections to the uncertainty of MonteCarlo calculations in micro- and nano-dosimetry [30min]
Fernanda Villegas, Sweden
The role of cavity size in microdosimetric specific energy distributions and linear-quadratic parameterization of cell survival [20min]
Marcin Pietrzak, Poland
On the two modes of nanodosimetric experiments - exercise with JET counter [20min]
Anna Selva, Italy
Nanodosimetry as a bridge between physics and radiobiology [20min]
13.00 Lunch - at the “San Trovaso Restaurant”
14.30-16.00 Session XIII – X-rays and Particles’ Micro- and Mini-beams: biological and clinical applications
Chair : D. Brenner, USA
Peter O’Neill, UK (Invited Speaker)
Tracking the fate of cellular DNA damage in real-time following microbeam irradiation with ultrasoft X-rays [30min]
Radu Vasilache, Romania
The development of a novel array detectors for overcoming the dosimetry challenges of measuring in very short pulsed charged particle beams - the ELIDOSE project [20min]
Matthias Würl, Germany
Development of two prototype spectrometers for laser-accelerated proton bunches [20min]
Judith N. Rivera, USA [RRS award]
Nano-scintillanting fiber optic dosimetry system for real-time microbeam radiation peak dose measurement [20min]
16.00-16.30 Coffee-Break
16.30-18.30 Session XIV - POSTER SESSION (Presentation of the posters with even ID numbers)
20.30 Social Dinner
Chiara La Tessa, Italy (Invited Speaker)
The role of microdosimetry in hadrontherapy and space radioprotection [30min]
Davide Bortot, Italy
A novel TEPC for microdosimetry at nanometric level: response against 62 AMeV He-4 ions [20min]
Jasper Kouwenberg, Netherland
Experimental Alpha Microdosimetry using Fluorescent Nuclear Track Detectors [20min]
10.45 - 11.15 Coffee-Break
11.15 -13.00 Session XII – Experimental and Computational Micro- and Nano-dosimetry (continuation)
Chair : A. Waker, Canada
Carmen Villagrasa, France (Invited Speaker)
Assessing the contribution of cross-sections to the uncertainty of MonteCarlo calculations in micro- and nano-dosimetry [30min]
Fernanda Villegas, Sweden
The role of cavity size in microdosimetric specific energy distributions and linear-quadratic parameterization of cell survival [20min]
Marcin Pietrzak, Poland
On the two modes of nanodosimetric experiments - exercise with JET counter [20min]
Anna Selva, Italy
Nanodosimetry as a bridge between physics and radiobiology [20min]
13.00 Lunch - at the “San Trovaso Restaurant”
14.30-16.00 Session XIII – X-rays and Particles’ Micro- and Mini-beams: biological and clinical applications
Chair : D. Brenner, USA
Peter O’Neill, UK (Invited Speaker)
Tracking the fate of cellular DNA damage in real-time following microbeam irradiation with ultrasoft X-rays [30min]
Radu Vasilache, Romania
The development of a novel array detectors for overcoming the dosimetry challenges of measuring in very short pulsed charged particle beams - the ELIDOSE project [20min]
Matthias Würl, Germany
Development of two prototype spectrometers for laser-accelerated proton bunches [20min]
Judith N. Rivera, USA [RRS award]
Nano-scintillanting fiber optic dosimetry system for real-time microbeam radiation peak dose measurement [20min]
16.00-16.30 Coffee-Break
16.30-18.30 Session XIV - POSTER SESSION (Presentation of the posters with even ID numbers)
20.30 Social Dinner
Friday, November 10, 2017 |
8.30-9.30 Refresher Course
Chair : W. Friedland, Germany
Emanuele Scifoni, Italy (Invited Speaker)
Biologically oriented treatment planning [50min]
9.30 - 10.45 Session XV – Risk assessment
Chair : H.G. Menzel, Germany
Dudley T. Goodhead, UK (Invited Speaker)
Biological effectiveness of lower-energy photons for cancer risk, with reference to the new NCRP report [30min]
Markus Eidemüller, Germany
PASSOS: methodology and software to assess long-term health risks after breast cancer therapy and heart diagnostic procedures [20min]
Marie Davidkova, Czech Republic
Properties of Nuclear Track Emulsions and their use in Neutron Dosimetry [20min]
10.45 - 11:15 Coffee-Break
11.30 -13.20 Session XVI – Advances in Radiotherapy including Hadrontherapy, BNCT, Radio-immunotherapy
Chair : M. Waligorski, Poland
Leszek Grzanka, Poland
The confusing role of LET in radiation therapy - will microdosimetry help ? [20min]
Tatsuhiko Sato, Japan
Application of stochastic microdosimetric kinetic model to boron neutron capture therapy [20min]
Eric Diffenderfer, USA
A time-resolved mini-TEPC measurement and data acquisition system for therapeutic proton beams - development and validation [20min]
Giulio Magrin, Austria
Ion-beam therapy and microdosimetry: effects of detector shapes and materials [20min]
Michal Pomorski, France
Single Crystal CVD Diamond Membrane Microdosimeters for Hadron Therapy [20min]
Marcello Serra, Italy
Characterization of a small FOV portable GC: MediPROBE [20min]
13.20 Symposium Closure
13.30 Lunch - at the “San Trovaso Restaurant”
oOo
15.00 Satellite Event
S.I.R.R. Annual General Meeting
