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Sep 13 – 19, 2015
La Biodola, Isola d'Elba
Europe/Rome timezone

Quantitative X-Ray Phase-Contrast Microtomography from a Compact Laser Driven Betatron Source

Sep 17, 2015, 6:40 PM
20m
15' + 5' discussion (La Biodola, Isola d'Elba)

15' + 5' discussion

La Biodola, Isola d'Elba

<a target="_blank" href=http://www.elba4star.it/en/>Hotel Hermitage</a>
talk WG4 - Application of compact and high-gradient accelerators/Advanced beam manipulation and control WG4 - Application of compact and high-gradient accelerators/Advanced beam manipulation and control

Speaker

Mr Johannes Wenz (Ludwig-Maximilians-Universität München)

Description

With excellent resolving power and tissue contrast, X-ray phase-contrast imaging holds great promise but the source requirements have limited its use. Here we present the first quantitative phase-contrast micro-tomogram of a biological specimen produced by a laser driven Betatron source. The fundamental mechanism behind the so called betatron radiation is the wiggling of the electrons in the radial fields of the plasma wake during the acceleration process. The um source size enables its use for producing high resolution phase contrast images by the free space propagation technique. These images combined with computed tomography technique are able to provide detailed information about the specimen. Along with the tomogram we present a comprehensive characterization of the electron acceleration process, which defines the Betatron source. For this purpose we have indirectly measured and analyzed the main X-ray properties, like source size and photon spectrum. We address the optimization of the source for phase-contrast imaging and the essential steps necessary for a quantitative reconstruction. Also a successful crosscheck of the retrieved electron densities against the values measured with an electron microscope confirming the accuracy of the source characterization and the validity of our approach will be presented.

Primary author

Mr Johannes Wenz (Ludwig-Maximilians-Universität München)

Co-authors

Prof. Franz Pfeiffer (Technical University Munich) Mr Gregor Schilling (1Ludwig-Maximilians-Universität München, Am Coulombwall 1, 85748 Garching, Germany) Hao Ding (LMU München) Mr Konstantin Khrennikov (Ludwig-Maximilians-University Munich (LMU), Max-Planck-Institute for Quantum Optics(MPQ)) Dr Martin Bech (4Medical radiation Physics, Clinical Sciences, Lund University) Mr Matthias Heigoldt (Ludwig-Maximilians-Universität München, Am Coulombwall 1, 85748 Garching, Germany) Mr Max Gilljohann (Ludwig-Maximilians-Universität München) Sabine Schindler (LMU München) Dr Simone Schleede (Lehrstuhl für Biomedizinische Physik, Physik-Department & Institut für Medizintechnik, Technische Universität München) Prof. Stefan Karsch (LMU Munich) Dr Thibault Pierre (Lehrstuhl für Biomedizinische Physik, Physik-Department & Institut für Medizintechnik, Technische Universität München)

Presentation materials