14th International Conference on Nuclear Microprobe Technology and Applications

Session

Session 4 - Nuclear Microprobe Applications: Biology 2

9 Jul 2014, 08:30

Palazzo del Bo and Centro Culturale San Gaetano, Padova

Conveners

Session 4 - Nuclear Microprobe Applications: Biology 2

• Richard Ortega (CENBG)

63. Reduced side effects by proton microchannel radiotherapy – studi in a human skin model

Prof. Gunther Dollinger (Universitaet der Bundeswehr Muenchen, Neubiberg, Germany)

09/07/2014, 08:30

Invited Technical Oral Communication

We propose a novel strategy to reduce the known side effects of radiotherapy by using proton microchannel irradiation. The goal is to minimize the risk of normal tissue damage by microchannel irradiation, while preserving local tumor control through a homogeneous irradiation of the tumor that is achieved because of beam widening with increasing track length. In order to prove the hypothesis of...

134. Automated high throughput analysis of metal atoms in biological macromolecules using Ion Beam Analysis

Dr Geoffrey Grime (University of Surrey Ion Beam Centre, Guildford, U.K.)

09/07/2014, 09:00

Invited Technical Oral Communication

As we have described previously [1,2], microbeam PIXE combined with simultaneous RBS analysis is the only accurate method easily available for identifying and quantifying the small number of metal atoms commonly present in large biological molecules such as proteins. This method has been in routine use at the Surrey Ion Beam Centre for several years, but is restricted in its range of...

12. Chemical imaging of bone regeneration induced by bioactive glass implants in vivo: a multimodal and quantitative micro-ion beam analysis of mineralization and trace elements at the bone interface

Dr Jonathan LAO (Laboratoire de Physique Corpusculaire CNRS-IN2P3 / Université Blaise Pascal, France)

09/07/2014, 09:30

Oral Communication

This communication will focus on the contribution of nuclear microprobes to the highly sensitive elemental analysis of bone tissues, in the context of evaluating the efficiency of bone regeneration induced by a bone substitute. Indeed the mineral composition of bone can give key clues on the maturity and the quality of the bone formed, the content in trace elements being especially...

87. In-vivo 3D PIXE-micron-CT imaging of Drosophila using contrast media

Dr Shigeo Matsuyama (Department of quantum Science and Energy Engineering, Tohoku University, Sendai, Japan)

09/07/2014, 09:50

Oral Communication

For the research field of biology and medicine, it is very useful to develop the technology in which an interior of small animals can be observed in-vivo and with a high resolution of several micron meters. For this purpose, we have developed a 3D CT with micrometer resolution. The system comprises a point X-ray source, a rotating sample stage and a high-speed X-ray CCD camera. A microbeam...

85. Targeted irradiation of cellular substructures at SNAKE

Mr Christian Siebenwirth (Department of Radiation Oncology, Technische Universität München, Germany)

09/07/2014, 10:10

Oral Communication

With the development of a highly precise targeted irradiation at the ion microbeam SNAKE, installed at the Munich 14 MV tandem accelerator, cellular response after irradiation of subcellular or even sub nuclear structures can be studied. Based on the live cell setup at SNAKE [1,2] it provides a sub micrometer single ion irradiation facility in combination with a high-resolution optical...