Speaker
Prof.
Harry J. Whitlow
(University of Applied Sciences (HES-SO), Haute Ecole Arc Ingénierie, Institut des Microtechnologies Appliquées Arc, Switzerland)
Description
Lithographic patterning with 16O+ ions has been demonstrated by us, and others in polytetrafluoroethylene (PTFE). Motivated by the molecular level similarity of PTFE with parylene-C and parylene-F; we have investigated the possibility of using 0.6–2 MeV oxygen ions to pattern these polymers using aperture mask lithography for prosthetic applications in inner-ear surgery.
Parylene-C and –F could be patterned in a similar way to that reported for PTFE. However, the removal per unit fluence for 1 MeV 16O+ was ~5% that for PTFE. Both films deposited on glass and silicon substrates and self-supporting films of Parylene-C could be patterned. We also investigated irradiation in a atmosphere of up to 10-3 mbar oxygen and observed any increase in removal rate for the polymers in question. Increasing the energy of the 16O+ beam from 600 keV to 2 MeV increased the removal rate of parylene-C ~1.5×.
Biocompatibility tests using murin Spiral Ganglia cells (SG) showed that there was no significant difference in SG cell proliferation between irradiated and unirradiated areas. Moreover, laminin and poly-L-lysine applied after ion irradiation completely dominate the cell attachment.
Primary author
Prof.
Harry J. Whitlow
(University of Applied Sciences (HES-SO), Haute Ecole Arc Ingénierie, Institut des Microtechnologies Appliquées Arc, Switzerland)
Co-authors
Dr
Alexandra Homsy
(University of Applied Sciences, Haute Ecole Arc Ingénierie, (HES-SO), La Chaux-de-Fonds, Switzerland)
Dr
Edith Laux
(University of Applied Sciences, Haute Ecole Arc Ingénierie, (HES-SO), La Chaux-de-Fonds, Switzerland)
Mr
Edouard Guibert
(University of Applied Sciences, Haute Ecole Arc Ingénierie, (HES-SO), La Chaux-de-Fonds, Switzerland)
Dr
Gianni. Fiorucci
(University of Applied Sciences, Haute Ecole Arc Ingénierie, (HES-SO), Neuchâtel, Switzerland)
Prof.
Herbert Keppner
(University of Applied Sciences, Haute Ecole Arc Ingénierie, (HES-SO), La Chaux-de-Fonds, Switzerland)
Dr
Marta Roccio
(Inner Ear Research Laboratory, Univ. Department of Otorhinolaryngology, Head and Neck Surgery, Inselspital, Bern, Switzerland)
Mr
Maxime Bergamin
(University of Applied Sciences, Haute Ecole Arc Ingénierie, (HES-SO), La Chaux-de-Fonds, Switzerland)
Prof.
Pascal Senn
(Inner Ear Research Laboratory, Univ. Department of Otorhinolaryngology, Head and Neck Surgery, Inselspital, Bern, Switzerland)
Dr
Patrick Jeanneret
(University of Applied Sciences, Haute Ecole Arc Ingénierie, (HES-SO), La Chaux-de-Fonds, Switzerland)
Dr
Rattanaporn Norarat
(Faculty of Science and Agriculture, Rajamangala University of Technology Lanna, Chiang Rai, Thailand)
