Speaker
Xiao Hong
(Beijing Changping Laboratory)
Summary
This work introduces a peptide-based chelation strategy to overcome the lack of stable radium chelators in nuclear medicine. Inspired by calcium- and barium-binding proteins, sequences were adapted for de novo cyclic peptide design, optimized via CNN modeling. A 14-residue cyclic peptide demonstrated strong binding, outperforming macropa derivatives. When immobilized on magnetic beads, it enabled >60% separation efficiency of radium-228 from thorium-rich solutions, improving distribution coefficients. This approach provides a foundation for efficient radium separation, enhanced isotope production, and expanded radiopharmaceutical applications beyond bone-targeting, addressing a longstanding challenge in radium chemistry.
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Authors
Xiao Hong
(Beijing Changping Laboratory)
Prof.
Zhibo Liu
(Peking University)
