Speaker
Mario Malinconico
(COMECER S.p.A. - R&D Department)
Summary
Cobalt 55 (55Co) is a promising PET isotope for extended imaging, thanks to its 17.5-hour half-life and relatively high proportions of β+ emission (Iβ+ = 77%, Eγ = 931.1 keV). Additionally, the high affinity of [55Co]Co2+ ions for commonly employed macrocyclic chelators, such as DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) provides a plethora of functionalised bioactive molecules that can readily be accessed for PET imaging. This preliminary study presents an automated workflow for [55Co]Co production via the 58Ni(p,α) 55Co reaction, aiming to establish a reproducible method with improved operator safety
Author
Mario Malinconico
(COMECER S.p.A. - R&D Department)
Co-authors
Ms
Mirea Ruscillo
(COMECER S.p.A. – R&D Department, Via Maestri del Lavoro, 90, 48014 Castel Bolognese, RA, Italy)
Dr
Courtney Hollis
(.. Molecular Imaging & Therapy Research Unit (MITRU), South Australian Health and Medical Research Institute (SAHMRI), North Terrace, Adelaide, SA 5000, Australia)
Dr
Edward Robins
(.. Molecular Imaging & Therapy Research Unit (MITRU), South Australian Health and Medical Research Institute (SAHMRI), North Terrace, Adelaide, SA 5000, Australia)
Dr
Chady Barkil
(.. Molecular Imaging & Therapy Research Unit (MITRU), South Australian Health and Medical Research Institute (SAHMRI), North Terrace, Adelaide, SA 5000, Australia)
Mr
Alessandro Brunetti
(COMECER S.p.A. - R&D Department)
Prof.
Romolo Laurita
(University of Bologna, Via Dei Colli, 16, 40136 Bologna (BO), Italy)
Prof.
Marco Sumini
(University of Bologna, Via Dei Colli, 16, 40136 Bologna (BO), Italy)
