26 May 2024 to 1 June 2024
La Biodola - Isola d'Elba (Italy)
Europe/Rome timezone

The reSPECT project: an innovative SPECT detection system based on high-Z organic scintillators

28 May 2024, 08:31
3h 59m
Sala Elena

Sala Elena

Poster T5 - Applications to Industrial and Societal Challenges Applications to Industrial and Societal Challenges - Poster session

Speaker

Giacomo Traini (INFN - Roma 1)

Description

The Global Cancer Observatory reports that in 2020 the European population had a 28.2% risk of developing cancer before the age of 75 years, with a 11.7% mortality risk. Such mortality rate can be reduced through early detection of tumours by means of imaging techniques. Among them, nuclear imaging scans play a pivotal role for noninvasive diagnosis. This contribution is focused on Single Photon Emission Computed Tomography (SPECT), a nuclear imaging technique that allows to inspect physiological processes inside the patient’s body through the detection of the gamma rays emitted by a radiopharmaceutical administered to the patient.

Conventional SPECT detection systems consist of a monolithic inorganic scintillation crystal, typically Thallium-activated sodium iodide, whose scintillation signal is read by an array of photomultiplier tubes. The innovative gamma detector concept investigated in this contribution, instead, relies on a Tungsten metal frame that serves both as a collimator and as a container for the scintillator segments. The reSPECT project involves the development of innovative organic scintillators doped with high-Z impurities, to profit from the extremely fast scintillation process, while maintaining a remarkable photoelectric effect probability (despite the plastic substrate) and a low cost. Moreover, the process of polymerization used to produce such scintillator segments permits to give them any desired size and geometrical shape.

Our project involves a custom readout system tuned for fast scintillation events and high rates, with an independent channel for each scintillator segment to improve the spatial resolution of the detector. A silicon readout system allows for a combination with MRI systems, while the ability to sustain high event rates opens the way to a possible theragnostic use.

In this contribution, the preliminary results obtained with the scintillator prototypes will be presented, in comparison with the solutions currently available on the market.

Role of Submitter I am the presenter

Primary authors

Alberto Burattini (Scuola post-laurea in Fisica Medica, Dipartimento di Scienze e Biotecnologie medico-chirurgiche, Sapienza Università di Roma, Italy) Alessio Sarti (Department of Basic and Applied Sciences for Engineering, Sapienza University of Rome, Via Antonio Scarpa 14, Rome, 00161, Italy) Angelica De Gregorio (Istituto Nazionale di Fisica Nucleare) Prof. Angelo Schiavi (Department of Basic and Applied Sciences for Engineering, Sapienza University of Rome, Via Antonio Scarpa 14, Rome, 00161, Italy) Annalisa Muscato (Scuola post-laurea in Fisica Medica, Dipartimento di Scienze e Biotecnologie medico-chirurgiche, Sapienza Universita` di Roma, Italy) Mr Antonio Trigilio (Università di Roma "La Sapienza") Daniele Rocco (Department of Basic and Applied Sciences for Engineering, Sapienza University of Rome, Via Antonio Scarpa 14, Rome, 00161, Italy) Flaminia Quattrini (Istituto Nazionale di Fisica Nucleare) Gaia Franciosini (Istituto Nazionale di Fisica Nucleare) Giacomo Traini (INFN - Roma 1) Giuseppe De Vincentis (Department of Radiological Sciences, Oncology and Anatomo-Pathology, University of Rome, Rome, Sapienza, 00185, Italy) Leonardo Mattiello (Department of Basic and Applied Sciences for Engineering, Sapienza University of Rome, Via Antonio Scarpa 14, Rome, 00161, Italy) Marco Garbini (Enrico Fermi” Historical Museum of Physics and Study & Research Centre-CREF, Via Panisperna 89a, Rome, 00184, Italy) Marco Magi (Istituto Nazionale di Fisica Nucleare) Marco Toppi (Istituto Nazionale di Fisica Nucleare) Michela Marafini (Istituto Nazionale di Fisica Nucleare) Riccardo Mirabelli (Istituto Nazionale di Fisica Nucleare) Viviana Frantellizzi (Department of Radiological Sciences, Oncology and Anatomo-Pathology, University of Rome, Rome, Sapienza, 00185, Italy) vincenzo patera (Department of Basic and Applied Sciences for Engineering, Sapienza University of Rome, Via Antonio Scarpa 14, Rome, 00161, Italy)

Presentation materials