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2nd Workshop - Trento Proton Beam Line Facility

17–18 Jun 2024
Trento
Europe/Rome timezone

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Contribution List

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  1. 53. Opening address
    Francesco Pederiva (TIFP)
    17/06/2024, 14:30
  2. 54. Trento Proton Therapy Center
    Frank Lohr (APSS - Unitn)
    17/06/2024, 14:40
  3. 55. CSN 5 perspectives
    Alberto Quaranta (TIFPA - University of Trento)
    17/06/2024, 14:50
  4. 32. Characterization of thin silicon detectors for applications in conventional and flash irradiations
    Francesco Pennazio (Istituto Nazionale di Fisica Nucleare)
    17/06/2024, 15:00
  5. 33. Dosimetric characterization of ultra-high dose rate proton beams for FLASH radiotherapy using calorimetry
    Giuliana Giuseppina Milluzzo (Istituto Nazionale di Fisica Nucleare)
    17/06/2024, 15:12
  6. 34. Beam and treatment monitoring in FLASH and CONV regimes for PT applications
    Giacomo Traini (Istituto Nazionale di Fisica Nucleare)
    17/06/2024, 15:24
  7. 35. Towards real-time dose control during cancer radiation therapies based on full-organic wearable dosimeter
    Laura Basiricò (Istituto Nazionale di Fisica Nucleare)
    17/06/2024, 15:36
  8. 36. Microdosimetry at the proton therapy facility of Trento
    Anna Bianchi (Istituto Nazionale di Fisica Nucleare)
    17/06/2024, 15:48
  9. 37. Proton-induced Radiation Damage Effects on Silicon Photomultipliers for HEP and space experiments
    Fabio Acerbi (FBK, TIFPA), fabio acerbi (FBK)
    17/06/2024, 16:20
  10. 38. xRadiation damage and mitigation strategies for the SiPM of the ePIC-dRICH detector at the EIC
    Dr Nicola Funicello (Istituto Nazionale di Fisica Nucleare)
    17/06/2024, 16:32
  11. 39. Study of SEU effects in readout circuits of silicon micro-strips detectors developed in 110 nm UMC technology.
    Daniela Calvo (Istituto Nazionale di Fisica Nucleare)
    17/06/2024, 16:44
  12. 40. p21: a new player in colon cancer cell radioresistance.
    Alessandra Bisio (Istituto Nazionale di Fisica Nucleare)
    17/06/2024, 17:05
  13. 42. The effect of particle therapy on tumour angiogenesis
    Charnay Cunningham
    17/06/2024, 17:17
  14. 43. Microtubules as IR target
    Simonetta Croci (Istituto Nazionale di Fisica Nucleare)
    17/06/2024, 17:29
  15. 47. MGM: development and validation of a microdosimetric genomic model to predict radiation-induced mutation in space
    Lorenzo Manganaro (TO)
    17/06/2024, 17:41
  16. 1. Continuous Microdosimetric Photon Isoeffective Dose Model: experimental measurements
    Lucrecia Mariel Valeriano (INFN-TIFPA)
    17/06/2024, 17:53

    This study presents the outcomes of combined radiobiological-microdosimetric experiments conducted in the same selected positions along the profile of a Spread-Out Bragg Peak (SOBP). The aim was to obtain the necessary parameters for a novel microdosimetric model for computing photon isoeffective doses in proton therapy [1-5]. This model, named Continuous Microdosimetric Photon Isoeffective...

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  17. 56. Overview of experimental research at the proton therapy facility Dresden
    Jörg Pawelke (OncoRay Dresden (Germany))
    18/06/2024, 09:15
  18. 57. The CNAO center and experimental facility: development and upgrades
    Marco Pullia (CNAO)
    18/06/2024, 09:35
  19. 44. FLASH understanding: the radiobiology program of FRIDA-WP1
    Emanuele Scifoni (INFN, Trento Institute for Fundamental Physics and Applications (TIFPA), Povo, TN, Italy)
    18/06/2024, 10:00
  20. 45. Validation of Trento’s Proton Centre for FLASH Radiotherapy: A Comparative Analysis, Insight from Zebrafish
    Alessia Faggian (Istituto Nazionale di Fisica Nucleare)
    18/06/2024, 10:12
  21. 16. A proton minibeam setup in the TPBL and the MIRO project
    Emanuele Scifoni (Istituto Nazionale di Fisica Nucleare)
    18/06/2024, 10:24

    Minibeam irradiation is seen as a new frontier for exploiting the advantages of proton beams, as well as other types of radiation, towards increasing the therapeutic ratio on clinical treatments. In this context a novel INFN project has been recently launched called MIRO - Minibeam Radiation, dedicated to the investigation of beam design and radiobiological effectiveness of electron and proton...

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  22. 46. Comparative study of the effects induced by innovative radiotherapy treatments in zebrafish
    Gaia Pucci (Institute of Molecular Bioimaging and Physiology–National Research Council (IBFM-CNR), Cefalù, Italy)
    18/06/2024, 11:00
  23. 41. Activation of the p53 pathway in combination with photon or proton irradiation for the treatment of brain tumours
    Xanthene Miles
    18/06/2024, 11:12
  24. 48. The Proton Radiography experiment
    Carlo Civinini (Istituto Nazionale di Fisica Nucleare)
    18/06/2024, 11:25
  25. 49. Characterization of FOOT silicon microstrip detectors with protons.
    Leonello Servoli (Istituto Nazionale di Fisica Nucleare)
    18/06/2024, 11:37
  26. 50. Test of amorphous silicon detectors on the Trento Proton Beam Line
    Leonello Servoli (Istituto Nazionale di Fisica Nucleare)
    18/06/2024, 11:49
  27. 51. The beam test journey of the HEPD-02 detector at Trento Proton therapy center
    Ester Ricci (Istituto Nazionale di Fisica Nucleare)
    18/06/2024, 12:01
  28. 52. Evaluating the Reliability of AI Accelerators with Proton Experiments
    Bruno Loreiro Coelho (University of Trento)
    18/06/2024, 12:13
  29. 7. Activation of the p53 pathway in combination with photon or proton irradiation for the treatment of brain tumours
    Xanthene Miles (iThemba LABS)

    p53 is a critical tumour suppressor protein and its encoding gene, TP53, is the most frequently mutated gene in human cancer. Activating the p53 pathway is regarded as a plausible strategy to increase radiosensitivity of cancer cells and reduce carcinogenesis. One of the strategies is to inhibit the interaction of p53 with its negative regulator MDM2, which represents a promising clinical...

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  30. 4. Beam and treatment monitoring in FLASH and CONV regimes for PT applications
    Giacomo Traini (Istituto Nazionale di Fisica Nucleare)

    With this contribution we want to report about the interest we have in the Trento facility related to research activities we are carrying on in the context of several INFN, CREF and Sapienza projects.

    The first activity that would profit from the collaboration with the Trento facility and the availability of a research proton beam delivered both at FLASH and Conventional rates is related to...

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  31. 17. Characterization of FOOT silicon microstrip detectors with protons.
    Dr Leonello Servoli (Istituto Nazionale di Fisica Nucleare)

    The FOOT (FragmentatiOn Of Target) multi-detector experiment aims at improving the accuracy of oncological hadrontherapy for tumor treatment. It studies the nuclear fragmentation due to the interactions of charged particle beams with patient tissues. Among the FOOT detection subsystems detectors, the Silicon Microstrip Detector is part of the charged-ions-tracking magnetic spectrometer. The...

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  32. 14. Characterization of thin silicon detectors for applications in conventional and flash irradiations
    Francesco Pennazio (Istituto Nazionale di Fisica Nucleare)

    Detector technology based on thin (~ 50 µm) silicon sensors is gaining interest for the possible applications in beam monitoring, quality assurance, treatment verification and dosimetry in radiation therapy. Compared to gas ionization chambers, thin silicon sensors feature superior sensitivity, allowing to measure single particles, increased spatial resolution, much faster signal collection...

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  33. 29. Closing Remarks
  34. 13. Comparative study of the effects induced by innovative radiotherapy treatments in zebrafish
    Dr Gaia Pucci (Institute of Molecular Bioimaging and Physiology–National Research Council (IBFM-CNR), Cefalù, Italy)

    Conventional radiotherapy (RT) is based on the administration of photon beams in the form of low Linear Energy Transfer (LET) radiation (X-rays), which deposit a relatively small amount of energy on the target and disperses it to the surrounding healthy tissue, due to scattering phenomena, differently from high LET radiation (protons), which is delivered directly on the target with minimal...

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  35. 23. Detectors - First Session
  36. 24. Detectors - Second Session
  37. 19. Dosimetric characterization of ultra-high dose rate proton beams for FLASH radiotherapy using calorimetry
    Giuliana Giuseppina Milluzzo (Istituto Nazionale di Fisica Nucleare)

    The recent discovery of the “FLASH” effect occurring delivering beams at average dose-rates exceeding 40 Gy/s and with a total irradiation time of < 300 ms, is leading to a growing interest in establishing the dosimetric and monitoring techniques that still assure the high level of accuracy needed for the clinical translation of FLASH radiotherapy [Romano et al., Med. Phys. 2022).
    An...

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  38. 10. Evaluating the Reliability of AI Accelerators with Proton Experiments
    Bruno Loureiro Coelho (University of Trento)

    Applications based on Artificial Intelligence (AI) are being employed in several fields, including medical diagnosis, drug discovery, robotics, and autonomous vehicles. Enabling robots and vehicles to perform tasks autonomously can be useful in several scenarios, particularly for space exploration and satellites [1]. This success can be attributed in great part to advances in AI models, such...

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  39. 21. FLASH understanding: the radiobiology program of FRIDA-WP1
    Emanuele Scifoni (Istituto Nazionale di Fisica Nucleare)

    Despite growing and accumulating evidence,the FLASH effect - i.e. the differential sparing of normal tissue versus a same efficacy on the tumor, when radiation is delivered at an ultra-high dose rate, as compared to a conventional way - remains largely unexplained mechanistically, a limit which hinders importantly its potential for a clinical translation. In this context the Workpackage 1...

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  40. 26. Invited Speakers Round Table
  41. 3. Microdosimetry at the proton therapy facility of Trento
    Dr Anna Bianchi (INFN Laboratori Nazionali di Legnaro (LNL), viale dell’Università 2, 35020, Legnaro, Italy)

    In the framework of the MICROBE_IT project funded by the 5th commission of INFN in the period 2021-2023, several microdosimetric measurements have been performed at the research beam lines of the proton therapy centre of Trento.
    The detector employed is a new miniaturized Tissue Equivalent Proportional Counter characterized by a cylindrical sensitive volume of 1.0 mm in diameter and height...

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  42. 15. Microtubules as IR target
    Simonetta Croci (UNIPR and Istituto Nazionale di Fisica Nucleare)

    Radiotherapy is a rapidly evolving domain encompassing various aspects, including the utilization of diverse beam types (protons, heavy ions, X-rays, electrons) and delivery methods, such as the emerging FLASH modality. To enhance clinical decision-making, a comprehensive understanding and modeling of physical, biophysical, and biological processes are essential. Initial and pivotal...

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  43. 11. p21: a new player in colon cancer cell radioresistance.
    Dr Alessandra Bisio (Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, Italy; Trentino Institute for Fundamental Physics and Applications (TIFPA))

    Radiation therapy is the most effective cytotoxic therapy to treat localized solid cancers. With the introduction of charged particle radiotherapy (such as proton therapy), the area of irradiated healthy tissue surrounding the tumor was further decreased. Unfortunately, radiotherapy resistance remains a major obstacle in tumor eradication, thus making it crucial to disentangle the complex...

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  44. 8. Proton-induced Radiation Damage Effects on Silicon Photomultipliers for HEP and space experiments
    Dr Fabio Acerbi (FBK)

    Silicon Photomultipliers (SiPMs) are single-photon sensitive detectors that continue to attract increasing interest in several industrial and scientific applications that require fast detection speed, high sensitivity, compactness, insensitivity to magnetic fields and low bias voltages. SiPMs are also replacing photomultiplier tubes (PMTs), hybrid photodiodes (HPDs), or other in high-energy...

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  45. 27. Radiation Biology - First Session
  46. 28. Radiation Biology - Second Session
  47. 30. Radiation damage and mitigation strategies for the SiPM of the ePIC-dRICH detector at the EIC
    Dr Nicola Funicello (Istituto Nazionale di Fisica Nucleare)

    The dual-radiator (dRICH) detector of the ePIC experiment at the Electron-Ion Collider (EIC) will be equipped with silicon photomultipliers (SiPM) sensors. SiPMs have excellent performance for efficient photodetection in high-magnetic field environments, but they are very sensitive to radiation damage. Rigorous testing is needed to ensure that their dark count rates (DCR) are kept under...

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  48. 25. Radiation Hardness
  49. 5. Study of SEU effects in readout circuits of silicon micro-strips detectors developed in 110 nm UMC technology.
    Daniela Calvo (Istituto Nazionale di Fisica Nucleare)

    At INFN-Torino, ASICs for readout of several detectors were designed and are under development using the 110 nm CMOS UMC. This technology has been chosen for its lower cost even if there was not a systematic characterization for what concerns the radiation tolerance. Total Ionizing Dose and Single Event Upset (SEU) effects measurements are important studies to characterize ASICs and then also...

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  50. 18. Test of amorphous silicon detectors on the Trento Proton Beam Line
    Leonello Servoli (Istituto Nazionale di Fisica Nucleare)

    Hydrogenated amorphous silicon (a-Si:H) is a well
    known material for its radiation resistance and for the possibility
    of deposition on flexible substrates like Polyimide (PI). The HASPIDE collaboration is developing a-Si:H devices both for
    dosimetry of clinical beams than flux measurement of other beam types.
    In this framework a test has been carried out at the Trento Proton Beam Line to...

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  51. 2. The beam test journey of the HEPD-02 detector at Trento Proton therapy center
    Ester Ricci (Istituto Nazionale di Fisica Nucleare)

    The HEPD-02, realized by the Limadou collaboration for the CSES-02 satellite, whose launch is planned for the end of 2024, will be the first detector operating in space to host a pixel-based tracker detector, as well as the largest LYSO bars realized for space applications.
    The detector aims to observe electron fluxes in the energy range between 3 and 100 MeV and protons fluxes between 30...

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  52. 20. The effect of particle therapy on tumour angiogenesis
    Charnay Cunningham (iThemba LABS)

    Non-small cell lung cancer (NSCLC) is the most prevalent type of lung cancer, which remains the leading cause of cancer-related mortality worldwide. Anti-angiogenic drugs, such as recombinant endostatin (RE), have been intensely studied to inhibit tumour angiogenesis in NSCLC, leading to mixed and often disappointing results in (pre)clinical trials. Despite the fact that previous studies...

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  53. 6. The Proton Radiography experiment
    Dr Carlo Civinini (INFN-Firenze)

    Abstract

    In recent years we have been witnessing a growing scientific interest in proton Radiography (p-Rad). The p-Rad systems, currently used in-vivo for proton range verification, operate by integrating the particle signal thus having limited spatial resolution together with a high dose.
    The main goal of this experiment is to develop, starting from the 'proton Computed Tomography'...

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  54. 9. Towards real-time dose control during cancer radiation therapies based on full-organic wearable dosimeter
    Laura Basiricò (Istituto Nazionale di Fisica Nucleare)

    Mechanical flexibility, portability, low cost of fabrication, scalability onto large areas and human tissue equivalence are crucial properties which make organic and hybrid semiconductors excellent candidates for the development of wearable proton dosimeters. Among others, their employment in the medical field (i.e. during proton therapy treatments) to monitor in real-time and in-situ the dose...

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  55. 12. Validation of Trento’s Proton Centre for FLASH Radiotherapy: A Comparative Analysis, Insight from Zebrafish
    Alessia Faggian (1 Department of Cellular, Computational and Integrative Biology, University of Trento, Trento, Italy; 2 Department of Physics, University of Trento, Trento, Italy)

    Radiotherapy is one of the main treatment options for cancer patients. The delivery of radiation sources and the reduction in damage to the surrounding healthy tissues have made significant progress in recent years. Particularly, the emergence of Ultra High Dose Rate (UHDR, also known as FLASH) radiotherapy is encouraging because it enhances treatment efficacy while minimizing side effects....

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  56. 22. Welcome