Conveners
Applications of Nuclear Physics III
- Cristina Vaccarezza (Istituto Nazionale di Fisica Nucleare)
Applications of Nuclear Physics III
- Francesco Tommasino (Istituto Nazionale di Fisica Nucleare)
Applications of Nuclear Physics III
- Maria Giuseppina Bisogni (Istituto Nazionale di Fisica Nucleare)
In the next years, the Italian Laboratori Nazionali di Frascati of INFN will
play a crucial role in the development of plasma-based acceleration techniques.
In fact, it is involved in the EuPRAXIA initiative, that aims at realizing the
first laser plasma user facility worldwide. The R&D activity ongoing in this
field is hosted at SPARC LAB (Sources for Plasma Accelerators and...
Introduction
Particle therapy relies on the peculiar depth dose deposition, featuring the Bragg peak to reduce the integral dose to healthy tissues. Technological improvements are needed to pursue new beam delivery modalities and develop an online verification system to ensure treatment quality. We propose an innovative beam monitor for particle therapy exploiting a silicon strip detector...
In the last decades silicon detectors have had the leading role in the field of charged particles tracking. Although the mainstay for these devices is hybrid sensors, where a front-end die gets bonded to a silicon sensor, Monolithic Active Pixel Sensors (MAPS), which embeds the sensing volume and the processing electronics within the same silicon layer, have attracted interest for current and...
The detection unity of the current Inner Tracking System of ALICE, called ITS2, is the ALPIDE sensor. This device is the result of an intensive R&D effort carried out in the last decade and has led to a quantum leap in the field of MAPS for single-particle detection, reaching unprecedented performance in terms of efficiency, spatial resolution, material budget and readout speed. The further...
Lutetium-yttrium oxyorthosilicate (LYSO) is a high density, rugged/radiation tolerant, fast scintillator. For this reason LYSO crystal scintillators are used or planned in many High Energy Particle experiments (as e.g., KLOE-2, srEDM, COMET, CMS Barrel Timing Layer) in medical diagnostic devices (PET, TAC, CT) and in current and planned astroparticle physics space calorimeters (as e.g.,...
With the recent experimental realization of quantum computing devices containing tens to hundreds of qubits and fully controllable operations, the theoretical effort in designing efficient quantum algorithms for a variety of problems has seen a tremendous growth worldwide. In this talk I will discuss the potential impact of quantum computing for application in nuclear physics and present some...
Boron Neutron Capture Therapy (BNCT) is an innovative and highly selective treatment against cancer. Nowadays in-vivo dose measurements and monitoring are important issues to carry out such therapy in clinical environments. In this work, different imaging methods were tested for dosimetry and tumor monitoring in BNCT based on a Compton camera detector. A dedicated data-set was generated...
Assessing the biological impact of radiation relies on understanding the fundamental interactions between radiation and matter. This is particularly essential in various fields, including radiotherapy cancer treatment. To link the physics of radiation to its biological effect, mathematical mechanistic models have been proven powerful tools. Consequently, developing an accurate and reliable...
FLASH radiotherapy is a novel technique based on Ultra-High Dose Rate (UHDR) irradiation (i.e., an overall dose rate > 40 Gy/s for a single dose > 10 Gy), which allows obtaining fewer side effects on healthy tissue and unchanged tumor effectiveness with respect to conventional delivery. In recent years, much experimental evidence [Schüler et al. Med. Phys. (2022)] confirmed this FLASH effect;...
In my talk I will illustrate the studies carried out at INFN-Ferrara on a novel idea of using bulk $\rm{MgB_2}$ superconductor as replacement of conventional superconducting magnets in particle physics experiments.
The advantages of this technology are many: possibility to use almost arbitrary shape/size; no need of current leads (reduced heat-load and size); no power consumption (beyond...
Radionuclides and radiopharmaceuticals are fundamental tools in nuclear medicine, by enabling imaging and treatment in tens of millions of procedures performed worldwide on a yearly basis. In Europe, 9 million patients benefit from nuclear medicine procedures per year, including 1.5 million patients requiring radionuclide therapy against cancer. The production of medical radionuclides is thus...
Nuclear inelastic interactions have an important role in particle therapy, radiation protection and in theoretical nuclear model studies. In particle therapy, the uncertainties on the evaluation of the nuclear inelastic interactions can lead to a miscalculation of the dose deposition evaluated by the treatment planning systems. In addition, a precise estimate of the fragmentation of 16O and...
Space research is object of a renewed interest, also considering that human missions to the Moon, and possibly Mars, are being planned. Astronauts’ exposure to space radiation is one the highest-priority problems. In the framework of the ARES project funded by INFN, we developed and applied the BIANCA biophysical model to calculate absorbed, equivalent and effective doses following astronauts’...
Elena Fogazzi1,2, Mara Bruzzi3,4, Elvira D’Amato1, Paolo Farace2,5, Francesco Fracchiolla2,5, Stefano Lorentini2,5, Roberto Righetto2,5, Monica Scaringella4, Marina Scarpa1,2, Francesco Tommasino1,2, Carlo Civinini4*
1 Physics department, University of Trento, via Sommarive 14, Povo (TN), Italy 2 Trento Institute for Fundamental Physics and Applications...
The novel approach of the precision nuclear medicine is tailoring the treatments on the patient instead of adapting the patient to standard therapies. The uniqueness of the patients’ response to treatments is now the focus of the latest research. To achieve this goal the use of radiopharmaceuticals suitable for theranostic applications is a valid strategy. Theranostics conjugates diagnosis and...
Targeted Radionuclide Therapy (TRT) is an emerging technique for cancer treatment. Radionuclides suitable for this technique could be produced at the Legnaro National Laboratories of the National Institute for Nuclear Physics (INFN-LNL), where a new facility for the production of Radioactive Ion Beams (RIB) called SPES is under construction. The production of radionuclides of medical interest...
Four of the terbium radioisotopes have great potential as theranostic radionuclides ($^{149}$Tb, $^{152}$Tb, $^{155}$Tb, and $^{161}$Tb). This work mainly focuses on $^{155}$Tb (I$_{ec}$ = 100%, T$_{1/2}$ = 5.32 d). It emits gamma rays with energies suitable for SPECT studies (86 keV, 105 keV) and the absence of β$^+$/ β$^-$ emissions reduces the radiotoxicity of this radionuclide. The...
The potential for developing compact, high-brightness particle and radiation sources have given a strong impetus to the development of the underpinning laser technology, including increasing the efficiency and repetition rate of the lasers. A result of this technological development can be seen in the new generation of ultrafast high-power laser systems working at a high repetition rate which...
