Speaker
Ms
Anna Konarska
(Institute of Applied Radiation Chemistry, Lodz University of Technology)
Description
Sanguinarine and coralyne are isoquinoline alkaloids isolated from plants. The use of these alkaloids as medicines by humans dates to several thousands of years ago and recently they are applied in cancer therapy.
Naturally occurring alkaloids are effective in cancer treatment but its mechanism of action has not been fully elucidated. Sanguinarine is reduced upon entering the cell and then undergo redox cycling between the reduced and oxidized forms causing the cell death by apoptosis [1]. The one-electron reduction or oxidation reactions of alkaloids are important for understanding the mechanism of generation radicals taking part in apoptosis.
The reactions of hydrated electron, carbon dioxide radical anion, hydrogen atom and Cl2•-, N3•, OH• radicals with coralyne and sanguinarine in aqueous solution have been studied by steady state and pulse radiolysis. The spectra of transient intermediates leading to the final products will be presented. The part of our presentation will be devoted to photoinduced electron transfer from excited triplet states to selected quenchers.
References:
[1] S.S. Matkar, L.A. Wrischnik, U. Hellmann-Blumberg, Archives of Biochemistry and Biophysics 2008, 477: 43-52
Acknowledgement: This work was supported by the grant N N204537339 from the Ministry of Science and Higher Education (Poland).
Primary author
Ms
Anna Konarska
(Institute of Applied Radiation Chemistry, Lodz University of Technology)
Co-authors
Dr
Marian Wolszczak
(Institute of Applied Radiation Chemistry, Lodz University of Technology)
Mrs
Milena Marszalek
(Institute of Applied Radiation Chemistry, Lodz University of Technology)
