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International Workshop on future research program with the high power Cyclotron of SPES-LNL

12–13 May 2025
LNL
Europe/Rome timezone

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Contribution List

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  1. 57. Welcome by LNL Director and INFN Executive Board
    12/05/2025, 09:30
  2. 58. Status of LNL Cyclotron
    Enrico Fagotti (Istituto Nazionale di Fisica Nucleare)
    12/05/2025, 09:45
  3. 33. Opening Talk (on line): Requirements for clinical translation of FLASH radiotherapy: What is needed? How can SPES-LNL contribute?
    Marie Catherine Vozenin (University of Geneva)
    12/05/2025, 10:10
  4. 59. Extreme ultra-high dose rate proton conditions and insights in FLASH radiotherapy mechanism: validation of models on multiple spatio-temporal scales
    Emanuele Scifoni (Istituto Nazionale di Fisica Nucleare)
    12/05/2025, 10:40
  5. 61. Exploiting the possibility to produce high flux proton minibeams
    Giuliana Giuseppina Milluzzo (Istituto Nazionale di Fisica Nucleare)
    12/05/2025, 11:30
  6. 62. Design of a transport and dosimetric beam line for proton therapy and radiobiological experiments
    Francesco Romano (INFN - Catania Section)
    12/05/2025, 11:50
  7. 63. Development of beam monitors for Ultra High Dose Rate Radiotherapy
    Umberto Deut (Istituto Nazionale di Fisica Nucleare)
    12/05/2025, 12:10
  8. 64. Characterization of new dosimeters with the high flux, high dose rate protons for FLASH radiotherapy
    Chinonso Okpuwe (Istituto Nazionale di Fisica Nucleare)
    12/05/2025, 12:30
  9. 65. FlashDC, a fluorescence based beam monitor for ultra-high dose rates
    Vincenzo Patera (Istituto Nazionale di Fisica Nucleare)
    12/05/2025, 12:50
  10. 66. A medical and multi-disciplinary in-air transport beam line for the 70 MeV protons from the INFN-LNL cyclotron
    Roberto Catalano (INFN-LNS)
    12/05/2025, 13:10
  11. 68. Opening Talk (on line): TBD
    Uli Koester (Institut Laue-Langevin, Grenoble)
    12/05/2025, 14:30
  12. 67. Opening Talk: Radioligands
    Laura Evangelista (HUMANITAS UNIVERSITY, Milano)
    12/05/2025, 15:00
  13. 69. Feasibility production of 67/64Cu mixture with SPES cyclotron for the first radiopharmaceutical in-vivo studies
    Liliana Mou (Istituto Nazionale di Fisica Nucleare)
    12/05/2025, 15:30
  14. 70. Thick targets yields measurements with natV targets for the production of the theranostic 47Sc
    Lucia De Dominicis (Istituto Nazionale di Fisica Nucleare)
    12/05/2025, 15:50
  15. 71. Hybrid polysiloxanes and nanocomposite scintillators for high energy and medical physics applications
    Sara Maria Carturan (LNL-INFN)
    12/05/2025, 16:10
  16. 72. Miniaturized Microdosimeters for Hadron Therapy AToMiQA -
    Anna Bianchi (Istituto Nazionale di Fisica Nucleare)
    12/05/2025, 16:30
  17. 79. HIgh-precision tests of the Pauli Exclusion Principle in proton-nucleus interactions using the SPES Cyclotron
    Catalina Oana Curceanu (Istituto Nazionale di Fisica Nucleare)
    12/05/2025, 17:20
  18. 81. Higher Energy CROSSTEST
    Emanuele Vincenzo Pagano (Istituto Nazionale di Fisica Nucleare)
    12/05/2025, 17:40
  19. 75. Radiation protection benchmark to test nuclear models between a nucleon within energy range 20 and 200 MeV and a light nucleus (C, N, O)
    Michaël Petit
    12/05/2025, 18:00
  20. 76. Opening Talk: Nuclear Physics with (p,x) reactions (while curing cancer at the same time)
    Lee A. Bernstein (Lawrence Berkeley National Laboratory)
    13/05/2025, 09:00
  21. 77. Neutrino physics from gamma-ray spectroscopy
    Damiano Stramaccioni (Istituto Nazionale di Fisica Nucleare)
    13/05/2025, 09:30
  22. 78. Production at SPES of a 94Nb radioactive source for studying the quenching of the weak interaction axial-vector coupling constant
    Francesco Cappuzzello (Istituto Nazionale di Fisica Nucleare)
    13/05/2025, 09:50
  23. 73. Beryllium target for proton-induced neutron production: CoolGal
    Alberto Monetti (Istituto Nazionale di Fisica Nucleare)
    13/05/2025, 10:10
  24. 84. Gamma-ray and conversion electron spectroscopy on irradiated targets + Umbrella Gamma Collaboration
    Andrea Gottardo (Istituto Nazionale di Fisica Nucleare)
    13/05/2025, 10:50
  25. 74. HBS Tantalum Target Development for Neutron Production at HiCANS
    Johannes Baggemann (JCNS, Forschungszentrum Jülich, Germany)
    13/05/2025, 11:10
  26. 82. γ-electron coincidence measurements with the BeGam set-up on the 70Zn(p,x) reaction products
    Marco Perri (Istituto Nazionale di Fisica Nucleare)
    13/05/2025, 11:30
  27. 83. Development of novel radiotracers for climate change
    Simone Rocca (Istituto Nazionale di Fisica Nucleare)
    13/05/2025, 11:50
  28. 55. A medical and multi-disciplinary in-air transport beam life for the 70 MeV protons from the INFN-LNL cyclotron

    Thanks to the expertise coming from over twenty years of dosimetric and clinical experience gained from operating the CATANA and zero-degree proton therapy beamlines at INFN-LNS, we propose the establishment of a multidisciplinary in-air irradiation facility at the newly operating INFN-LNL cyclotron, which can deliver protons with energies up to 70 MeV and currents ranging between 20 nA and 50...

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  29. 17. AToMiQA – Young Researchers’ Grant 5th Commission INFN (2025-2026)
    Anna Bianchi (Istituto Nazionale di Fisica Nucleare)

    The new young researchers' grant AToMiQA has the aim of developing a microdosimetry system capable of measuring in high intensity beams. To this aim the newly commissioned LNL cyclotron offers a unique opportunity to test detectors starting with low beam currents to evaluate sensitivity and performance under minimal radiation exposure, then progressively increasing intensity to assess their...

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  30. 9. Beryllium target for proton-induced neutron production: CoolGal
    Alberto Monetti (Istituto Nazionale di Fisica Nucleare)

    Compact accelerator-driven neutron sources (CANS) provide excellent opportunities for generating intense neutron beams. As research nuclear reactors close, CANS provide a cost-effective alternative, supporting communities that rely on advanced neutron instrumentation; in addition, their distributed nature allows for broader accessibility, including use as training centers. The potential...

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  31. 26. Characterization of new dosimeters with the high flux, high dose rate protons for FLASH radiotherapy

    The content is provided in the attached PDF file

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  32. 25. Design of a transport and dosimetric beam line for protontherapy and radiobiological experiments

    Proposal attached

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  33. 21. Development of beam monitors for Ultra High Dose Rate Radiotherapy

    The paradigm of radiation therapy is the optimization of the therapeutic ratio, i.e. striking a balance between effectively damaging malignant tissue and preserving surrounding healthy tissue. Among the most promising developments are the treatment modalities exploiting the FLASH effect, a normal tissue sparing effect demonstrated in electron and proton irradiations at ultra-high dose-rate...

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  34. 5. Development of novel radiotracers for climate change

    The purpose of this LOI is to study the production method of a new radiotracer, within the
    framework of the REMO/ ClimOcean project, dedicated to developing a novel methodology for
    monitoring the effects of climate change on marine species using radioisotopes. Radio tracer
    applications are essential instruments in evaluating the changes in some key biological processes,
    e.g. primary...

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  35. 24. Exploiting the possibility to produce high flux proton minibeams

    For the content of the abstract, see the PDF file in attachment.

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  36. 22. Extreme ultra-high dose rate proton conditions and insights in FLASH radiotherapy mechanism: validation of models on multiple spatio-temporal scales

    see attached file

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  37. 13. Feasibility production of 67/64Cu mixture with SPES cyclotron for the first radiopharmaceutical in-vivo studies

    Copper-67 (67Cu, T1/2 61.9 h), as well as Copper-64 (64Cu, T1/2 12.7 h), are under the spotlight of the scientific community as single isotopes for targeted radionuclide therapy, and as a pair for theragnostic applications thanks to the, β- and γ emissions of 67Cu and β- and β+ emission of 64Cu . Their half-lives are suitable for tracking radiopharmaceuticals with slow pharmacokinetics....

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  38. 56. FlashDC, a fluorescence based beam monitor for ultra-high dose rates

    Thanks to the expertise coming from over twenty years of dosimetric and clinical experience gained from operating the CATANA and zero-degree proton therapy beamlines at INFN-LNS, we propose the establishment of a multidisciplinary in-air irradiation facility at the newly operating INFN-LNL cyclotron, which can deliver protons with energies up to 70 MeV and currents ranging between 20 nA and 50...

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  39. 10. Gamma-ray and conversion electron spectroscopy on irradiated targets

    We propose to irradiate different targets in the ISOL bunker 2 to then perform off-line $\gamma$-ray and conversion $e^-$ spectroscopy on the long-living isotopes (at least 30 min) created by the 35-70 MeV protons. After irradiation, the targets can be placed in measurement setups like the b-DS tape station outside the bunker where detailed spectroscopy can be performed.
    We highlight two...

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  40. 80. Gamma-ray and conversion electron spectroscopy on irradiated targets + Umbrella Gamma Collaboration
    Andrea Gottardo (Istituto Nazionale di Fisica Nucleare)
  41. 12. HBS Tantalum Target Development for Neutron Production at HiCANS

    Within the HBS (High Brilliance neutron Source) project, the Jülich Centre for neutron Science (JCNS) at Forschungszentrum Jülich has developed a new kind of HiCANS which shall serve as a competitive user facility. One of its key components is the neutron target designed to operate at a 70 MeV proton beam. It is designed as a stationary solid tantalum target consisting of three layers as shown...

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  42. 7. High-precision tests of the Pauli Exclusion Principle in proton-nucleus interactions using the SPES Cyclotron

    Introduction & Scientific Motivation: The Pauli Exclusion Principle (PEP) is one of the fundamental tenets of quantum mechanics, dictating the behavior of identical fermions within a system. While extensively tested (by us) for electrons within the VIP (VIolation of the Pauli exclusion principle) experiment using high-precision X-ray spectroscopy [1], its validity for nucleons remains an open...

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  43. 27. Higher Energy CROSSTEST
    Emanuele Vincenzo Pagano (Istituto Nazionale di Fisica Nucleare)

    Proposals (expression of interest)
    We propose a test experiment on the EJ276 and EJ276G scintillators, to study their properties and peculiarities in order to realize a new challenging neutron and charge particle detector device.
    The study and construction of such a detector has been recently approved and financed in the framework of the national PRIN2020 funding call. The name of this...

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  44. 19. Hybrid polysiloxanes and nanocomposite scintillators for high energy and medical physics applications
    Dr Sara Maria Carturan (LNL-INFN)

    Organic scintillators have found widespread use in several fields of physics as radiation sensors, owing to their peculiar chemical and physical properties. They are lightweight, easy to produce in different volumes and shapes, they commonly offer a fast response and are also tissue-equivalent in medical dosimetry. In high energy physics, these features are harnessed to collect and reveal the...

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  45. 18. Miniaturized Microdosimeters for Hadron Therapy

    Microdosimetry is a spectrometric technique which measures energy imparted by ionizing radiation in sensitive volumes of micrometric dimensions. Starting from microdosimetric quantities it is possible to derive radiation quality descriptors of interest for the clinics, such as the Linear Energy Transfer (LET) or a physics-based estimation of the Relative Biological Effectiveness (RBE), using...

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  46. 15. Neutrino physics from gamma-ray spectroscopy

    Nuclear matrix elements (NMEs) are crucial for understanding weak interaction processes such as inverse beta decay (IBD) and neutrinoless double-beta decay (0νββ), which provide insights into neutrino properties and physics beyond the Standard Model. A novel experimental approach aims to extract NMEs using electromagnetic (EM) transitions from isobaric analog states (IAS). In this Expression...

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  47. 6. Production at SPES of a 94Nb radioactive source for studying the quenching of the weak interaction axial-vector coupling constant

    The present proposal aims at the production of a solid state 94Nb beta-emitting radioactive source via the proton irradiation of a 94ZrO2 thin film (~200 μg/〖cm〗^2 areal density) evaporated onto a multilayer graphene (MLG) sheet, via 94Zr(p,n)94Nb reaction at 35 MeV incident energy. The source will be exposed to an array of silicon drift detectors (SDD) in order to study the shapes of the beta...

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  48. 23. Radiation protection benchmark to test nuclear models between a nucleon within energy range 20 and 200 MeV and a light nucleus (C, N, O)

    EURADOS has established that there is a weakness [1] in the nuclear model concerning the interaction of a
    nucleon with an energy of between 20 and 200 MeV with light nuclei, primarily carbon, nitrogen and oxygen.
    However, this type of interaction is fundamental for describing the transport of nucleons in the human body
    as in secondary dose calculation in protontherapy for example. This type...

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  49. 14. Thick target yields measurements with natV targets for the production of the theranostic 47Sc

    47Sc is an emerging medical radionuclide with potential in the field of theranostic applications. Its favourable decay characteristics, namely β- particles of 162.0 keV mean energy, γ rays of about 159 keV energy, and a half-life of 3.3492 d, make it suitable for use in the radiolabelling of radiopharmaceuticals for cancer diagnosis using SPECT (Single Photon Emission Computed Tomography)...

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  50. 28. Welcome speech
  51. 20. γ-electron coincidence measurements with the BeGam set-up on the 70Zn(p,x) reaction products

    The Florence group is involved in a project (BeGam) aimed at the implementation of a portable device for the detection of $\beta$ emitting contaminants in radiotracers used in medical diagnostics from Nuclear Medicine imaging. Its use is particular important when the radionuclide is produced in a nuclear reaction induced by medical cyclotrons. The BeGam project focuses on techniques for...

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