Andrea Gonzalez-Montoro
(Institute for Instrumentation in Molecular Imaging, i3M-CSIC)
Combining PET with other imaging techniques such as MR or US devices has gained interest to, for example, provide anatomical information or to improve drug administration, respectively.
Recently, special interest has arisen in the use of Focal US (FUS) to open the Brain Blood Barrier (BBB) to allow drugs pass through the brain. However, since the FUS lacks of visual information it is difficult to ensure that the US are being delivered accurately and, therefore, its combination with imaging techniques such as PET or MR would represent a great advance.
To improve this area of medical imaging, we have designed and validated a pre-clinical PET device that can be used as a part of a trimodal system that combines PET-MR-FUS.
We report in this contribution the preliminary performance evaluation of the PET system as well as its compatibility to simultaneously work with our home-made low-field MR and FUS devices.
In particular, we show the preliminary NEMA results obtained with our custom PET insert, as well as the first reconstructed images (PET and MR) acquired with the trimodal system. For the trimodal study we designed a phantom that contains a layer of melting gelatin and a mixture of Cooper Sulfate and 18F. PET and MR data were simultaneously acquired while the phantom was being heated-up using FUS. The reconstructed images showed the mixing process of the elements inside the phantom when the gelatin was melting which is comparable to the process of opening the BBB.
| Field |
Systems and applications
|
Andrea Gonzalez-Montoro
(Institute for Instrumentation in Molecular Imaging, i3M-CSIC)
Marta Freire
(Institute for Instrumentation in Molecular Imaging, i3M-CSIC)
Fernando López
(Institute for Instrumentation in Molecular Imaging, i3M-CSIC)
Adolfo González-Tamarit
(Institute for Instrumentation in Molecular Imaging, i3M-CSIC)
Santiago Jiménez-Serrano
(Institute for Instrumentation in Molecular Imaging, i3M-CSIC)
Koldo Vidal
(Institute for Instrumentation in Molecular Imaging, i3M-CSIC)
Antonio Gonzalez
(Institute for Instrumentation in Molecular Imaging, i3M-CSIC)
Carlos de Alfonso
(Institute for Instrumentation in Molecular Imaging, i3M-CSIC)
Irene Torres
(ISS La Fe)
Diana Andrés
(Institute for Instrumentation in Molecular Imaging, i3M-CSIC)
Juan J. R. García
(Institute for Instrumentation in Molecular Imaging, i3M-CSIC)
Jose L. Alonso
(Institute for Instrumentation in Molecular Imaging, i3M-CSIC)
Alicia Carrión
(Institute for Instrumentation in Molecular Imaging, i3M-CSIC)
Teresa Guallart-Naval
(Institute for Instrumentation in Molecular Imaging, i3M-CSIC)
José M. Algarín
(Institute for Instrumentation in Molecular Imaging, i3M-CSIC)
Rubén Bosch
(Institute for Instrumentation in Molecular Imaging, i3M-CSIC)
Eduardo Pallás
(Institute for Instrumentation in Molecular Imaging, i3M-CSIC)
Stuart S. Berr
(Department of Radiology and Medical Imaging, The University of Virginia)
Mark B. Williams
(Department of Radiology and Medical Imaging, The University of Virginia)
María J. Rodriguez-Álvarez
(Institute for Instrumentation in Molecular Imaging, i3M-CSIC)
Francisco Camarena
(Institute for Instrumentation in Molecular Imaging, i3M-CSIC)
Joseba Alonso
(Institute for Instrumentation in Molecular Imaging, i3M-CSIC)
José María Benlloch Baviera
(Institute for Instrumentation in Molecular Imaging, i3M-CSIC)
