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PSMR2024 10th Conference on PET, SPECT, and MR Multimodal Technologies, Total Body and Fast Timing in Medical Imaging

19–23 May 2024
La Biodola, Isola d'Elba
Europe/Rome timezone

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Session

High-performance preclinical and organ-specific systems

23 May 2024, 08:30
La Biodola, Isola d'Elba

La Biodola, Isola d'Elba

Hotel Hermitage

Conveners

High-performance preclinical and organ-specific systems

  • Nuno Matela (Faculdade de Ciências da Universidade de Lisboa - Instituto de Biofísica e Engenharia Biomédica)
  • Gabriela Llosa (Instituto de Física Corpuscular (IFIC/CSIC-UVEG))

Presentation materials

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  1. 2. ISOLPHARM project: Development of two preclinical imaging devices for Ag-111 β and γ radiation
    Alberto Andrighetto (Istituto Nazionale di Fisica Nucleare)
    23/05/2024, 08:30
    High-performance preclinical and organ-specific systems
    Oral

    Interesting radionuclides for nuclear medicine applications are usually produced in cyclotrons or in nuclear research reactors. These production methods are typically associated with highly enriched target costs and with contaminated products. In this context, the ISOLPHARM project, the medical application of ISOL SPES facility, aims to produce radionuclides of medical interest with high...

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  2. 36. Characterize the Effective Half Life for Instant Single Time Point Dosimetry using Machine Learning
    Carlos Vinícius Gomes Ferreira (Inselspital)
    23/05/2024, 08:50
    High-performance preclinical and organ-specific systems
    Oral

    Single time point (STP) dosimetry offers a more convenient approach for clinical practice in radiopharmaceutical therapy (RPT) compared to conventional multiple time point (MTP). Despite numerous advancements, STP methods are limited and challenging by the need for strict and late timing in data acquisition. This study introduces a new concept of instant STP (iSTP), which is achieved by...

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  3. 15. SAFIR-II: Design and performance of a high-rate preclinical PET-MR System
    Jan Debus (ETH Zürich)
    23/05/2024, 09:10
    High-performance preclinical and organ-specific systems
    Oral

    The SAFIR collaboration has developed a high-
    performance PET insert compatible with a Bruker BioSpec 70/30
    MRI scanner. This system, named SAFIR-II, was designed to
    acquire data at activities of up to 500 MBq, enabling truly
    simultaneous preclinical PET-MR imaging for mice and rats
    using image acquisition times of up to 5 s.
    We present an overview of the system’s design, as well...

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  4. 41. Reaching new horizons in pre-clinical imaging: trimodal PET-FUS-MR technology
    Andrea Gonzalez-Montoro (Institute for Instrumentation in Molecular Imaging, i3M-CSIC)
    23/05/2024, 09:30
    High-performance preclinical and organ-specific systems
    Oral

    Combining PET with other imaging techniques such as MR or US devices has gained interest to, for example, provide anatomical information or to improve drug administration, respectively.
    Recently, special interest has arisen in the use of Focal US (FUS) to open the Brain Blood Barrier (BBB) to allow drugs pass through the brain. However, since the FUS lacks of visual information it is...

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  5. 59. The HYPMED Breast PET/MRI Insert: MRI Compatibility and Comparison to Whole Body PET/MRI
    Bjoern Weissler (RWTH Aachen, Hyperion HIS)
    23/05/2024, 09:50
    High-performance preclinical and organ-specific systems
    Oral

    Commercially available PET/MRI scanners have been designed as whole-body systems. In these, PET spatial resolution and sensitivity are limited. Dedicated PET inserts can potentially overcome these limitations. The EU H2020 project HYPMED developed a local PET insert for a clinical 1.5 T MRI for breast cancer research.
    The HYPMED insert combines a local MRI receive coil and two PET rings that...

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  6. 75. PET Imaging of the Human Brain at 2 µL Resolution with a Next-Generation Ultra-High-Resolution (UHR) Scanner
    Francis Loignon-Houle (Université de Sherbrooke; Institute for Instrumentation in Molecular Imaging (i3M CSIC-UPV))
    23/05/2024, 10:10
    High-performance preclinical and organ-specific systems
    Oral

    PET is an ideal imaging modality for studying human brain biochemistry in vivo, but its potential is limited by its poor spatial resolution, which is currently well below the theoretical limit. The brain-dedicated UHR scanner is designed to achieve 2 µL volumetric resolution for accurate characterization of brain regions previously indistinguishable without MRI. Unlike most PET systems, the...

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