Name: LEAPS Meets Life Sciences Conference
Start: 2023-05-14T17:00:00+02:00
End: 2023-05-19T07:30:00+02:00
Location: Hotel Hermitage, La Biodola Bay, Elba Island, Italy

Monday, May 8, 2023
Tuesday, May 9, 2023
Wednesday, May 10, 2023
Thursday, May 11, 2023
Friday, May 12, 2023
Saturday, May 13, 2023
Sunday, May 14, 2023

5:00 PM REGISTRATION
REGISTRATION
5:00 PM - 7:30 PM

7:30 PM Welcome Cocktail
Welcome Cocktail
7:30 PM - 8:30 PM

8:30 PM Dinner
Dinner
8:30 PM - 10:30 PM

Monday, May 15, 2023
8:45 AM Welcome to LEAPS Meets Life Sciences Conference - Caterina Biscari (Chair LEAPS Conference 2023)
Welcome to LEAPS Meets Life Sciences Conference
- Caterina Biscari (Chair LEAPS Conference 2023)
8:45 AM - 9:15 AM
9:15 AM Block 1
Block 1
9:15 AM - 10:15 AM
Contributions

9:15 AM Tutorial 1: Metagenomics: The key to new biology for basic protein research and application - Oded Beja (The Louis and Lyra Richmond Chair in Life Sciences, Faculty of Biology, Technion - Israel Institute of Technology, Haifa 3200003, Israel)
10:15 AM Coffee Break
Coffee Break
10:15 AM - 10:45 AM
10:45 AM Block 2
Block 2
10:45 AM - 11:15 AM
Contributions

10:45 AM Novel Biology Research at Paul Scherrer Institute - Gebhard F.X. Schertler (Paul Scherrer Institute, Switzerland)
11:15 AM Block 1
Block 1
11:15 AM - 12:00 PM
Contributions

11:15 AM Keynote 1: Serial diffraction of macromolecular systems - Henry Chapman (Center for Free-Electron Laser Science, DESY and University of Hamburg, Germany)
12:00 PM

12:00 PM - 12:15 PM
12:15 PM Poster talk
Poster talk
12:15 PM - 12:30 PM
Contributions

12:15 PM Gatekeepers of Prolyl-4-Hydroxylase 2 and mechanistic studies - Giorgia Fiorini
12:30 PM Lunch
Lunch
12:30 PM - 4:00 PM
4:00 PM Block 2
Block 2
4:00 PM - 5:30 PM
Contributions

4:00 PM Tutorial 2: The impact of artificial intelligence (AI) and computer simulations on biomolecular research - Jana Selent (Research Group on Biomedical Informatics, Hospital del Mar Medical Research Institute & Pompeu Fabra University, Barcelona, Spain)

5:00 PM Piz Daint on Alps: a modern day view of extreme computing and data in science - Thomas Schulthess (CSCS - Swiss National Supercomputing Centre)
5:30 PM

5:30 PM - 6:45 PM
6:45 PM Block 3
Block 3
6:45 PM - 7:15 PM
Contributions

6:45 PM Toward three-dimensional structure using X-ray free-electron laser - Florence Tama (RIKEN Center for Computational Science)
7:15 PM Block 1
Block 1
7:15 PM - 8:30 PM
Contributions

7:15 PM Keynote 2: Microsecond time-resolved cryo-electron microscopy - Ulrich Lorenz (Ecole Polytechnique Fédérale de Lausanne (EPFL), Switzerland)

8:00 PM New opportunities for time-resolved serial crystallography at the new ID29 from the ESRF extremely brilliant source - Julien Orlans (ESRF)
8:30 PM Dinner
Dinner
8:30 PM - 10:30 PM
Tuesday, May 16, 2023
8:45 AM Block 2
Block 2
8:45 AM - 10:15 AM
Contributions

8:45 AM Tutorial 3: The XFEL Hub at Diamond – enabling dynamic structural biology experiments locally & globally - Allen Orville (Diamond Light Source, U.K.)

9:45 AM Ultrafast dynamics of visual rhodopsin using an X-ray free electron laser - Valerie Panneels (Paul Scherrer Institute)
10:15 AM Coffee Break
Coffee Break
10:15 AM - 10:45 AM
10:45 AM Block 3
Block 3
10:45 AM - 12:00 PM
Contributions

10:45 AM Structure ensemble determination from ultrashort pulse single molecule X-ray scattering: a Bayesian approach - Helmut Grubmüller (Max Planck Institute for Multidisciplinary Sciences)

11:15 AM Keynote 3: Order from Disorder: Towards molecular architecture of the muscle Z-disk assembly by integrative structural biology - Kristina Djinovic Carugo (European Molecular Biology Laboratory (EMBL) Grenoble, 71 Avenue des Martyrs, 38000 Grenoble, France; Department of Structural and Computational Biology, Max Perutz Labs, University of Vienna, Campus Vienna Biocenter 5, 1030 Vienna, Austria)
12:00 PM Lunch
Lunch
12:00 PM - 1:00 PM

1:00 PM Excursion
Excursion
1:00 PM - 4:45 PM

4:45 PM

4:45 PM - 5:00 PM
5:00 PM Poster talk
Poster talk
5:00 PM - 5:15 PM
Contributions

5:00 PM X-ray structural studies of ba3-type cytochrome c oxidase - Doris Zoric
5:15 PM Block 1
Block 1
5:15 PM - 6:15 PM
Contributions

5:15 PM Tutorial 4: Advanced X-ray imaging: from the nanoscale at synchrotrons to clinical applications in hospitals - Marco Stampanoni (Paul Scherrer Institute and ETH Zürich)
6:15 PM Coffee Break
Coffee Break
6:15 PM - 6:45 PM
6:45 PM Block 2
Block 2
6:45 PM - 8:30 PM
Contributions

6:45 PM Keynote 4: Multi-scale in situ structural biology in the UK national cryoEM facility eBIC - Peijun Zhang (Diamond Light Source/ University of Oxford)

7:30 PM Human lung virtual histology by multi-scale X-ray phase-contrast computed tomography - Jakob Reichmann (University of Göttingen)

8:00 PM Multilevel X-ray imaging approach to assess the sequential evolution of multi-organ damage in neurodegenerative diseases - Francesca Palermo (Institute of Nanotechnology - CNR)
8:30 PM Dinner
Dinner
8:30 PM - 10:30 PM
Wednesday, May 17, 2023
8:45 AM Block 1
Block 1
8:45 AM - 10:30 AM
Contributions

8:45 AM Keynote 5: Structure-guided approaches to malaria vaccines - Matt Higgins

9:30 AM Ambient-temperature serial femtosecond crystallography studies of bacterial ribosome antibiotic complexes - Hasan Demirci (Koç University, Istanbul, Turkey)

10:00 AM Large scale imaging of neuronal networks of the brain - Adrian Wanner
10:30 AM Coffee Break
Coffee Break
10:30 AM - 11:00 AM
11:00 AM Block 2
Block 2
11:00 AM - 12:30 PM
Contributions

11:00 AM Molecular mechanisms of tau filament formation - Sofia Lovestam

11:30 AM Integrative structural biology applied to virus infection - Winfried Weissenhorn (University Grenoble Alpes)

12:00 PM Pandemic responses and the impact of infrastructure and technology on structural studies - Dave Stuart (Dave Stuart Strubi, Department of Medicine, University of Oxford and Diamond Light Source, U.K.)
12:30 PM Lunch
Lunch
12:30 PM - 4:00 PM
4:00 PM Poster talks
Poster talks
4:00 PM - 4:45 PM
Contributions

4:00 PM The First Ambient Temperature Structure of Large Ribosomal Subunit from Thermus Thermophilus - Bilge Tosun Cahine Kulakman (Koc University)

4:15 PM Selecting Synthetic Photoswitches for Time-Resolved Serial Crystallography of the Human A2A Receptor - Hannah Glover (Paul Scherrer Institut)

4:30 PM JINXED: Just in Time Crystallization for Easy Structure Determination of Biological Macromolecules - Alessandra Henkel (Center for Free-Electron Laser Science, DESY)
4:45 PM Block 1
Block 1
4:45 PM - 5:30 PM
Contributions

4:45 PM Keynote 6: Structure-based drug discovery in biotech and pharma - Michael Hennig (leadXpro AG, Park Innovaare, 5234 Villigen, Switzerland)
5:30 PM

5:30 PM - 6:45 PM
6:45 PM Block 2
Block 2
6:45 PM - 8:15 PM
Contributions

6:45 PM Structure analyze HIV-1 Gag-IP6 complexes using ambient-temperature X-ray crystallography and in-solution Small-angle X-ray scattering. - Nurettin Tokay

7:15 PM Photopharmacology: Where light and molecules meet crystallography - Amadeu Llebaria (MCS, Laboratory of Medicinal Chemistry & Synthesis, Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), 08034 Barcelona, Spain)

7:45 PM Watching the release of a photopharmacological drug from its target using SLS and SwissFEL - Jörg Standfuss (Division of Biology and Chemistry, Paul Scherrer Institut, 5232 Villigen, Switzerland)
8:15 PM Social Dinner and Dance
Social Dinner and Dance
8:15 PM - 10:30 PM
Thursday, May 18, 2023
8:45 AM Block 3
Block 3
8:45 AM - 10:00 AM
Contributions

8:45 AM Keynote 7: Four-dimensional structural analysis of membrane proteins and its application to drug discovery - So Iwata (Graduate School of Medicine, Kyoto University and RIKEN SPring-8 Center)

9:30 AM Detuning of the ribosome conformational landscape promotes antibiotic resistance and collateral sensitivity - Guillermo Montoya (NNF-CPR University of Copenhagen) Pablo Mesa (NNF-CPR)
10:00 AM Block 1
Block 1
10:00 AM - 10:30 AM
Contributions

10:00 AM LEAPS and the future of life sciences at large facilities - Jean Susini (Synchrotron SOLEIL)
10:30 AM Coffee Break
Coffee Break
10:30 AM - 11:00 AM
11:00 AM Block 2
Block 2
11:00 AM - 11:30 AM
Contributions

11:00 AM Light sources serving life and other sciences: A view from the US - Roger Falcone (University of California, Berkeley)

11:15 AM Synchrotrons for biology, examples from the US - Greg Hura (Lawrence Berkeley National Laboratory, U.S.)
11:30 AM Panel Discussion
Panel Discussion
11:30 AM - 12:30 PM

12:30 PM Lunch
Lunch
12:30 PM - 4:00 PM
4:00 PM Poster talk
Poster talk
4:00 PM - 4:15 PM
Contributions

4:00 PM Studying structural dynamics in biology at SLAC National Accelerator Laboratory - Sandra Mous (SLAC National Accelerator Laboratory)
4:15 PM Block 1
Block 1
4:15 PM - 5:45 PM
Contributions

4:15 PM Integrative Biology to tackle mitochondrial respiration in Alzheimer’s pathogenesis - Montserrat Soler Lopez (ESRF)

4:45 PM Cryo-trapped atomic resolution single crystal structures combined with time-resolved serial crystallography to explore enzyme mechanisms - Arwen Pearson (Universität Hamburg / CFEL) Ashwin Chari (MPI for Multidisciplinary Sciences, Göttingen)

5:15 PM Time-resolved serial crystallography studies of conformational changes in cytochrome c oxidase - Richard Neutze
5:45 PM Discussion
Discussion
5:45 PM - 6:15 PM

6:15 PM Coffee Break
Coffee Break
6:15 PM - 6:45 PM

6:45 PM Summary and outlook
Summary and outlook
6:45 PM - 7:45 PM

7:45 PM Conclusion
Conclusion
7:45 PM - 8:15 PM

8:15 PM Social Aperitivo
Social Aperitivo
8:15 PM - 9:00 PM

9:00 PM Farewell Dinner
Farewell Dinner
9:00 PM - 11:00 PM
Friday, May 19, 2023

7:00 AM Bus Depature
Bus Depature
7:00 AM - 7:30 AM