Name: LEAPS Meets Life Sciences Conference
Start: 2023-05-14T17:00:00+02:00
End: 2023-05-19T07:30:00+02:00
Location: Hotel Hermitage, La Biodola Bay, Elba Island, Italy

Monday, 8 May 2023
Tuesday, 9 May 2023
Wednesday, 10 May 2023
Thursday, 11 May 2023
Friday, 12 May 2023
Saturday, 13 May 2023
Sunday, 14 May 2023

17:00 REGISTRATION
REGISTRATION
17:00 - 19:30

19:30 Welcome Cocktail
Welcome Cocktail
19:30 - 20:30

20:30 Dinner
Dinner
20:30 - 22:30

Monday, 15 May 2023
08:45 Welcome to LEAPS Meets Life Sciences Conference - Caterina Biscari (Chair LEAPS Conference 2023)
Welcome to LEAPS Meets Life Sciences Conference
- Caterina Biscari (Chair LEAPS Conference 2023)
08:45 - 09:15
09:15 Block 1
Block 1
09:15 - 10:15
Contributions

09:15 Tutorial 1: Metagenomics: The key to new biology for basic protein research and application - Oded Beja (The Louis and Lyra Richmond Chair in Life Sciences, Faculty of Biology, Technion - Israel Institute of Technology, Haifa 3200003, Israel)
10:15 Coffee Break
Coffee Break
10:15 - 10:45
10:45 Block 2
Block 2
10:45 - 11:15
Contributions

10:45 Novel Biology Research at Paul Scherrer Institute - Gebhard F.X. Schertler (Paul Scherrer Institute, Switzerland)
11:15 Block 1
Block 1
11:15 - 12:00
Contributions

11:15 Keynote 1: Serial diffraction of macromolecular systems - Henry Chapman (Center for Free-Electron Laser Science, DESY and University of Hamburg, Germany)
12:00

12:00 - 12:15
12:15 Poster talk
Poster talk
12:15 - 12:30
Contributions

12:15 Gatekeepers of Prolyl-4-Hydroxylase 2 and mechanistic studies - Giorgia Fiorini
12:30 Lunch
Lunch
12:30 - 16:00
16:00 Block 2
Block 2
16:00 - 17:30
Contributions

16:00 Tutorial 2: The impact of artificial intelligence (AI) and computer simulations on biomolecular research - Jana Selent (Research Group on Biomedical Informatics, Hospital del Mar Medical Research Institute & Pompeu Fabra University, Barcelona, Spain)

17:00 Piz Daint on Alps: a modern day view of extreme computing and data in science - Thomas Schulthess (CSCS - Swiss National Supercomputing Centre)
17:30

17:30 - 18:45
18:45 Block 3
Block 3
18:45 - 19:15
Contributions

18:45 Toward three-dimensional structure using X-ray free-electron laser - Florence Tama (RIKEN Center for Computational Science)
19:15 Block 1
Block 1
19:15 - 20:30
Contributions

19:15 Keynote 2: Microsecond time-resolved cryo-electron microscopy - Ulrich Lorenz (Ecole Polytechnique Fédérale de Lausanne (EPFL), Switzerland)

20:00 New opportunities for time-resolved serial crystallography at the new ID29 from the ESRF extremely brilliant source - Julien Orlans (ESRF)
20:30 Dinner
Dinner
20:30 - 22:30
Tuesday, 16 May 2023
08:45 Block 2
Block 2
08:45 - 10:15
Contributions

08:45 Tutorial 3: The XFEL Hub at Diamond – enabling dynamic structural biology experiments locally & globally - Allen Orville (Diamond Light Source, U.K.)

09:45 Ultrafast dynamics of visual rhodopsin using an X-ray free electron laser - Valerie Panneels (Paul Scherrer Institute)
10:15 Coffee Break
Coffee Break
10:15 - 10:45
10:45 Block 3
Block 3
10:45 - 12:00
Contributions

10:45 Structure ensemble determination from ultrashort pulse single molecule X-ray scattering: a Bayesian approach - Helmut Grubmüller (Max Planck Institute for Multidisciplinary Sciences)

11:15 Keynote 3: Order from Disorder: Towards molecular architecture of the muscle Z-disk assembly by integrative structural biology - Kristina Djinovic Carugo (European Molecular Biology Laboratory (EMBL) Grenoble, 71 Avenue des Martyrs, 38000 Grenoble, France; Department of Structural and Computational Biology, Max Perutz Labs, University of Vienna, Campus Vienna Biocenter 5, 1030 Vienna, Austria)
12:00 Lunch
Lunch
12:00 - 13:00

13:00 Excursion
Excursion
13:00 - 16:45

16:45

16:45 - 17:00
17:00 Poster talk
Poster talk
17:00 - 17:15
Contributions

17:00 X-ray structural studies of ba3-type cytochrome c oxidase - Doris Zoric
17:15 Block 1
Block 1
17:15 - 18:15
Contributions

17:15 Tutorial 4: Advanced X-ray imaging: from the nanoscale at synchrotrons to clinical applications in hospitals - Marco Stampanoni (Paul Scherrer Institute and ETH Zürich)
18:15 Coffee Break
Coffee Break
18:15 - 18:45
18:45 Block 2
Block 2
18:45 - 20:30
Contributions

18:45 Keynote 4: Multi-scale in situ structural biology in the UK national cryoEM facility eBIC - Peijun Zhang (Diamond Light Source/ University of Oxford)

19:30 Human lung virtual histology by multi-scale X-ray phase-contrast computed tomography - Jakob Reichmann (University of Göttingen)

20:00 Multilevel X-ray imaging approach to assess the sequential evolution of multi-organ damage in neurodegenerative diseases - Francesca Palermo (Institute of Nanotechnology - CNR)
20:30 Dinner
Dinner
20:30 - 22:30
Wednesday, 17 May 2023
08:45 Block 1
Block 1
08:45 - 10:30
Contributions

08:45 Keynote 5: Structure-guided approaches to malaria vaccines - Matt Higgins

09:30 Ambient-temperature serial femtosecond crystallography studies of bacterial ribosome antibiotic complexes - Hasan Demirci (Koç University, Istanbul, Turkey)

10:00 Large scale imaging of neuronal networks of the brain - Adrian Wanner
10:30 Coffee Break
Coffee Break
10:30 - 11:00
11:00 Block 2
Block 2
11:00 - 12:30
Contributions

11:00 Molecular mechanisms of tau filament formation - Sofia Lovestam

11:30 Integrative structural biology applied to virus infection - Winfried Weissenhorn (University Grenoble Alpes)

12:00 Pandemic responses and the impact of infrastructure and technology on structural studies - Dave Stuart (Dave Stuart Strubi, Department of Medicine, University of Oxford and Diamond Light Source, U.K.)
12:30 Lunch
Lunch
12:30 - 16:00
16:00 Poster talks
Poster talks
16:00 - 16:45
Contributions

16:00 The First Ambient Temperature Structure of Large Ribosomal Subunit from Thermus Thermophilus - Bilge Tosun Cahine Kulakman (Koc University)

16:15 Selecting Synthetic Photoswitches for Time-Resolved Serial Crystallography of the Human A2A Receptor - Hannah Glover (Paul Scherrer Institut)

16:30 JINXED: Just in Time Crystallization for Easy Structure Determination of Biological Macromolecules - Alessandra Henkel (Center for Free-Electron Laser Science, DESY)
16:45 Block 1
Block 1
16:45 - 17:30
Contributions

16:45 Keynote 6: Structure-based drug discovery in biotech and pharma - Michael Hennig (leadXpro AG, Park Innovaare, 5234 Villigen, Switzerland)
17:30

17:30 - 18:45
18:45 Block 2
Block 2
18:45 - 20:15
Contributions

18:45 Structure analyze HIV-1 Gag-IP6 complexes using ambient-temperature X-ray crystallography and in-solution Small-angle X-ray scattering. - Nurettin Tokay

19:15 Photopharmacology: Where light and molecules meet crystallography - Amadeu Llebaria (MCS, Laboratory of Medicinal Chemistry & Synthesis, Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), 08034 Barcelona, Spain)

19:45 Watching the release of a photopharmacological drug from its target using SLS and SwissFEL - Jörg Standfuss (Division of Biology and Chemistry, Paul Scherrer Institut, 5232 Villigen, Switzerland)
20:15 Social Dinner and Dance
Social Dinner and Dance
20:15 - 22:30
Thursday, 18 May 2023
08:45 Block 3
Block 3
08:45 - 10:00
Contributions

08:45 Keynote 7: Four-dimensional structural analysis of membrane proteins and its application to drug discovery - So Iwata (Graduate School of Medicine, Kyoto University and RIKEN SPring-8 Center)

09:30 Detuning of the ribosome conformational landscape promotes antibiotic resistance and collateral sensitivity - Guillermo Montoya (NNF-CPR University of Copenhagen) Pablo Mesa (NNF-CPR)
10:00 Block 1
Block 1
10:00 - 10:30
Contributions

10:00 LEAPS and the future of life sciences at large facilities - Jean Susini (Synchrotron SOLEIL)
10:30 Coffee Break
Coffee Break
10:30 - 11:00
11:00 Block 2
Block 2
11:00 - 11:30
Contributions

11:00 Light sources serving life and other sciences: A view from the US - Roger Falcone (University of California, Berkeley)

11:15 Synchrotrons for biology, examples from the US - Greg Hura (Lawrence Berkeley National Laboratory, U.S.)
11:30 Panel Discussion
Panel Discussion
11:30 - 12:30

12:30 Lunch
Lunch
12:30 - 16:00
16:00 Poster talk
Poster talk
16:00 - 16:15
Contributions

16:00 Studying structural dynamics in biology at SLAC National Accelerator Laboratory - Sandra Mous (SLAC National Accelerator Laboratory)
16:15 Block 1
Block 1
16:15 - 17:45
Contributions

16:15 Integrative Biology to tackle mitochondrial respiration in Alzheimer’s pathogenesis - Montserrat Soler Lopez (ESRF)

16:45 Cryo-trapped atomic resolution single crystal structures combined with time-resolved serial crystallography to explore enzyme mechanisms - Arwen Pearson (Universität Hamburg / CFEL) Ashwin Chari (MPI for Multidisciplinary Sciences, Göttingen)

17:15 Time-resolved serial crystallography studies of conformational changes in cytochrome c oxidase - Richard Neutze
17:45 Discussion
Discussion
17:45 - 18:15

18:15 Coffee Break
Coffee Break
18:15 - 18:45

18:45 Summary and outlook
Summary and outlook
18:45 - 19:45

19:45 Conclusion
Conclusion
19:45 - 20:15

20:15 Social Aperitivo
Social Aperitivo
20:15 - 21:00

21:00 Farewell Dinner
Farewell Dinner
21:00 - 23:00
Friday, 19 May 2023

07:00 Bus Depature
Bus Depature
07:00 - 07:30