1st Workshop - Trento Proton Beam Line Facility

Session

Radiobiology & related applications

RADBIOa

9 Nov 2020, 11:30

Conveners

Radiobiology & related applications: Contributions RADBIO

• Daria Boscolo (GSI Helmholtzzentrum für Schwerionenforschung)
• Alessandra Bisio (University of Trento - CIBIO )
• Giada Onorato (Università di Torino and Università della Campania )
• Matthias Würl (LMU Ludwig-Maximilians-Universität München, Faculty of Physics, Department of Medical Physics)
• Giacomo Casati (Ospedale Pediatrico "Meyer"-FI )

Presentation materials

RADBIO.7z

17. The lack of p21 sensitizes colon cancer cells to radiation-induced apoptosis.

Dr Alessandra Bisio (Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, Italy)

09/11/2020, 11:30

Radiation therapy is the most-effective cytotoxic therapy available for the treatment of localized solid cancers. With the introduction of charged particle radiotherapy (proton therapy), the area of irradiated healthy tissue surrounding the tumor was further decreased. The aim of this study is to investigate the role of p53 in both X-rays and proton therapy treatments. p53 is a transcription...

8. Preliminary results on biological effects and molecular alterations induced by combined proton-therapy and chemotherapy in high-grade glioma treatment

Dr Giacomo Casati (Ospedale Pediatrico Meyer)

09/11/2020, 11:40

Although three decades of research have been trialled, the prognosis for patients with high-grade gliomas (HGGs) has not significantly changed.
The aim of our project is the development of a new combined treatment that could sensitize HGGs to therapies, reducing side effects and improving quality of life of the patients.
We will develop a new multidisciplinary protocol, combining the...

7. Development of C. elegans as a model for studying neurodegeneration in space-related conditions

Dr Onorato Giada (University of Torino and Università della Campania “Luigi Vanvitelli” (CE))

09/11/2020, 11:50

In light of future human exploration of deep space, a fundamental need is to understand how terrestrial organisms may be affected by the peculiar conditions that characterize this extreme environment. Moreover, it will be crucial to dissect how the individual genetic structure may jeopardize or facilitate the adaptation to deep space, with specific regards to normal functioning of the nervous...

11. Oxygen depletion measurements for different media with energetic proton beams.

Daria Boscolo (GSI Helmholtzzentrum für Schwerionenforschung)

09/11/2020, 12:00

The radiosensitivity of biological systems is strongly affected by the system oxygenation. On the molecular level, this effect is considered to be related to the indirect damage and in particular to the effect of the OH• radicals. Several theories have been developed and among them the so called oxygen fixation hypothesis is so far the most accepted one. Recent studies open up another possible...

16. Development of a setup for small-animal proton imaging based on a miniaturized Timepix detector

Dr Matthias Würl (Ludwig-Maximilians-Universität München, Faculty of Physics, Department of Medical Physics)

09/11/2020, 12:10

The SIRMIO (Small Animal Proton Irradiator for Research in Molecular Image-guided Radiation-Oncology) project [1] aims at developing a portable preclinical proton irradiator that can be installed at existing proton therapy centres. The clinical beam properties will be adapted to match requirements of small-animal irradiation using a dedicated energy degradation and focussing system [2]....