Advancing Particle Therapy requires models for biologically optimized treatment planning systems (TPS) in ion beam therapy, and dedicated devices for plan verification, allowing validation accounting for a wide range of complex physical and biological effects.
The MoVe IT project (INFN Call group V) aims at exploiting both modeling and verification methods for ion beam TPS with a main focus on RBE, biological impact of nuclear fragmentation (including target fragments) and intra-tumor heterogeneity.
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