The NPAIV conference is the fourth in the NPA, Nuclear Physics in Astrophysics, biennial series. The ﬁrst conference was held in the Institute of Nuclear Research of the Hungarian Academy of Sciences (ATOMKI), Debrecen, Hungary in 2002. The purpose of the NPA conferences is to bring together Nuclear Physics and Astrophysics giving the scientiﬁc community the possibility to review and discuss the status and prospects of the Nuclear Astrophysics ﬁeld. The conference will be held at Laboratori Nazionali del Gran Sasso, INFN, Assergi, L’Aquila, Italy etween 08-12 June, 2009. The Gran Sasso National Laboratory LNGS is one of four INFN national laboratories. It hosts experiments from the ﬁelds of Astroparticle Physics, Nuclear Astrophysics and other disciplines which require a low background environment. In particular the LUNA facility represents the worldwide only underground accelerator. LNGS is located nearby the village of Assergi inside the “Parco Nazionale del Gran Sasso and Monti della Laga” and close to the town of L’Aquila, the capital of the Abruzzo region. The history of region is a fascinating blend of traditions and legends, L’Aquila was founded in mid-13th century. The territory costs a unique natural environment with rare species of ﬂora and fauna. It is also rich in history with architectural (romanesque and gothic churches) and archaeological features back to the Roman times.