Conveners
Session 8 - Poster Session I
- Jae Sung Lee (South Korea)
- Harry Tsoumpas (University of Leeds)
Pablo Conde
(Institute for Instrumentation in Molecular Imaging, I3M-CSIC)
5/19/15, 4:00 PM
1 - Advances in MR-PET instrumentation: detectors
Poster
In PET detectors based on monolithic scintillators, the photon impact position can be estimated from the light intensity distribution (LD) on the photodetector pixels. Typically, there is a poor estimation of the interaction positions towards the edges when linear algorithms such as Center of Gravity (CoG) are used. We present a novel method to determine the interaction coordinates in thick...
Susanne Passow
(Department of Biological and Medical Psychology, University of Bergen, Norway; NORMENT Center of Excellence, University of Oslo, Norway)
5/19/15, 4:00 PM
7 - Clinical MR-PET
Poster
Default-mode network (DMN) functional connectivity and its task-dependent down-regulation have attracted a lot of attention in the field of neuroscience. Nevertheless, the exact underlying mechanisms of DMN functional connectivity, or more specifically, the blood oxygen level-dependent (BOLD) signal, are still not completely understood. To investigate more directly the association between...
Chen Zeng
(Huazhong University of Science & Technology), Mr
Daoming Xi
(Huazhong University of Science & Technology), Mr
Xiang Liu
(Huazhong University of Science & Technology)
5/19/15, 4:00 PM
1 - Advances in MR-PET instrumentation: detectors
Poster
Nowadays the simultaneous PET/MRI is being paid more and more attentions. Since MRI provides a high resolution, unsurpassed soft tissue contrast imaging and PET reveal the metabolism progress in molecular level, it is reasonable to believe the PET/MRI will be a powerful tool to improve the understanding of pathogenesis and mechanism of brain disease. Such a simultaneous system can be...
Matteo Galasso
(R)
5/19/15, 4:00 PM
3 - Advances in MR-PET and MR-SPECT software and quantification
Poster
In this paper we report on the development of a mathematical model, based on the estimation theory, for the performance analysis of different gamma-ray interaction position estimation methods applied to gamma cameras based on monolithic scintillators. The gamma camera performance is expressed in terms of bias and spatial resolution. We propose a method to investigate performances of various...
Yueh Hsu
(National Taiwan University)
5/19/15, 4:00 PM
3 - Advances in MR-PET and MR-SPECT software and quantification
Poster
A quantitative reconstruction of radiotracer activity distribution in positron emission tomography (PET) requires correction of attenuation, which was typically estimated through transmission measurements. The advancement in hardware development has prompted the use of time-of-flight (TOF) to improve PET imaging. Recently, the application of TOF-PET has been further extended to obtain...
Elena Rota Kops
(Forschungszentrum Juelich, Juelich, Germany)
5/19/15, 4:00 PM
3 - Advances in MR-PET and MR-SPECT software and quantification
Poster
Attenuation correction of PET data acquired in hybrid MR/PET scanners is still a challenge. Different methods have been adopted by several groups to obtain reliable attenuation maps (mu-maps). In this study we compare three methods: MGH, UCL, Neural-Network. The MGH method is based on an MR/CT template obtained with the SPM8 software. The UCL method uses a database of MR/CT pairs. Both...
LI CHENG
(Institute of Medical Physics, Department of Engineering Physics, Tsinghua University, Beijing, China)
5/19/15, 4:00 PM
6 - Whole-body and dedicated organ MR-PET
Poster
Aims: This work is to replace PET ring in human brain PET/MR system with a dedicated wearable PET insert, aimed at improving both patient feasibility and system performance for brain imaging.
Methods and materials: The designed PET/MR system include two parts: the inside parts, including a radio frequency (RF) coil and PET ring, are mounted on patient’ head, and the outside part, a MR imager,...
Lynn J. Frohwein
(European Institute for Molecular Imaging, University of Muenster, Germany)
5/19/15, 4:00 PM
7 - Clinical MR-PET
Poster
Due to the varying position and shape of flexible MRI RF surface coils, the creation of attenuation maps for these coils is a challenging task. Nevertheless, coil material (metal, plastic, rubber) attenuates the PET signal to a considerable amount. Thus, including a coil µ-map into the human µ-map is essential. In this work, we present a method to determine the position and shape of flexible...
Qingyang Wei
(Tsinghua University)
5/19/15, 4:00 PM
1 - Advances in MR-PET instrumentation: detectors
Poster
Silicon Photomultiplier (SiPM) is a promising sensor for PET detector which is able to work normally in the MR environment. In this paper, we developed a compact DOI-PET detector based on an 8x8 SiPM (MicroFB-30035-SMT) array and two layers of LYSO arrays. A 15x15 top layer placed half crystal offset on a 16x16 bottom layer and then coupled to the SiPM array. Size of the LYSO crystals in both...
Yingjie Wang
(Institute of High Energy Physics, Chinese Academy of Sciences)
5/19/15, 4:00 PM
2 - Advances in MR-PET instrumentation: systems
Poster
PET/MR is a new multi-modality imaging system which provide both structural and functional information with good soft tissue imaging ability and no ionizing radiation. In recent years, PET/MR is under major progress because of the development of silicon photomultipliers (SiPM). The goal of this study is to develop a MRI compatible PET insert based on SiPM and LYSO scintillator. The PET system...
Stratos David
(Department of Biomedical Engineering, Technological Educational Institute of Athens, Athens, Greece.)
5/19/15, 4:00 PM
1 - Advances in MR-PET instrumentation: detectors
Poster
SiPM arrays are insensitive to magnetic fields and thus good candidates for hybrid PET/MR imaging systems. Moreover, due to their small size and flexibility can be used in dedicated small field of view small animal imaging detectors and especially in head PET/MR studies in mice. Co-doped LFS-3 scintillator crystals have higher light yield and slightly faster response than that of LSO:Ce mainly...
Antonio Gonzalez
(Institute for Instrumentation in Molecular Imaging, i3M-CSIC)
5/19/15, 4:00 PM
1 - Advances in MR-PET instrumentation: detectors
Poster
In this work we present the first evaluation results of an array of 12x12 SiPMs MicroFC-30035-SMT from SensL. These sensors are basically identical to those custom fabricated for the brain PET insert of the MindView project, except for the larger package. Both the C-Series and MindView parts are built with the same principle resulting on low dark noise contributions. These arrays cover an...
Ihnho Cho
(Department of nuclear medicine, Yeungnam University Hospital)
5/19/15, 4:00 PM
6 - Whole-body and dedicated organ MR-PET
Poster
Purpose: We evaluated the artifacts in segmentation-based attenuation correction maps (μ-maps) of hybrid positron emission tomography/magnetic resonance (PET/MR) mammography using dedicated PET/MR breast coil in breast cancer patients. Materials and Methods: Attenuation map of hybrid F-18 FDG PET/MR mammography in 38 patients diagnosed with invasive breast carcinoma were retrospectively...
Nikos Efthimiou
(Technological Educational Institute of Athens)
5/19/15, 4:00 PM
5 - Preclinical MR-PET
Poster
Traditionally, most clinical and preclinical PET scanners, rely on full cylindrical geometry for whole body as well as dedicated organ scans, which is not optimized with regards to sensitivity and resolution.
Several groups proposed the construction of dedicated PET inserts for MR scanners, rather than the construction of new integrated PET/MR scanners. The space inside an MR scanner is...
Jarmo Teuho
(Turku PET Centre)
5/19/15, 4:00 PM
2 - Advances in MR-PET instrumentation: systems
Poster
The Philips Ingenuity TF is a sequential PET/MR with an Achieva 3T X-series MR and Gemini TF PET system connected with a rotating table. Both the PET and MR systems are designed to minimize mutual system interference.
However, a longitudinal study concerning the stability of the MR system has not been conducted before. The stability of the MR system affects diffusion weighted imaging (DWI),...
Ashley Tao
(McMaster University)
5/19/15, 4:00 PM
4 - Advances in MR-SPECT instrumentation
Poster
While mammography is the gold standard for breast cancer screening, it suffers from poor sensitivity in women with dense breast tissue. Both breast MRI and molecular breast imaging (MBI) have been used as secondary imaging techniques. However, breast MRI suffers from low specificity and low sensitivity in MBI. A CZT based detector system has been developed with the goal of simultaneous MBI/MRI...
Rimas Vaisnoras
(Crystals Laboratory,Institute of Science and Technology, Lithuanian University of Educational Sciences, Lithuania)
5/19/15, 4:00 PM
8 - Bimodal MR-PET tracers
Poster
Today sensitivity of the MRI is not enough compared to the nuclear methods, such as positron emission tomography and single photon emission computed tomography.Challenging, its extension to the nanometre scale could provide a powerful new tool for the nanosciences and nanomedicine.To achieve this potential, innovative new detection strategies are required to overcome the severe sensitivity...
Maria Georgiou
(Technological Educational Institute of Athens)
5/19/15, 4:00 PM
1 - Advances in MR-PET instrumentation: detectors
Poster
The purpose of this study is to investigate the behavior of the new generation of SensL SiPM arrays, ArrayB and ArrayM, for PET/MR applications.
The evaluation of the SiPMs performance underwent with pixelated GaGG and BGO scintillators with 2x2x5mm3 pixel size and various coupling schemes for 511keV and 662keV energies. To acquire raw images, we used a symmetric resistive voltage division...
Hayley Bignell
(University of Hull)
5/19/15, 4:00 PM
8 - Bimodal MR-PET tracers
Poster
Superparamagnetic iron oxide nanoparticles (SPIONs) are used as T2 magnetic resonance (MR) contrast agents. Nanorods (NRs) offer an interesting alternative to the more widely used nanospheres as they have enhanced T2 relaxivities. The combination of MRI with nuclear imaging modalities such as positron emission tomography (PET) or single photon emission computed tomography (SPECT) increases the...
Claes Ladefoged
(Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet Copenhagen, DK)
5/19/15, 4:00 PM
3 - Advances in MR-PET and MR-SPECT software and quantification
Poster
In the absence of transmission sources in combined clinical PET/MR systems, MR images are used for MR-based attenuation correction (MRAC). The main challenge in MR-AC is to separate the bone and air, as neither have a signal in the MR images. In the attenuation maps supplied by the vendor, a single value is assigned to bone using an ultra-short echo time (UTE) MR sequence. The purpose of this...
Udunna C Anazodo
(Lawson Health Research Institute, Department of Medical Biophysics, Western University, London, ON, Canada)
5/19/15, 4:00 PM
7 - Clinical MR-PET
Poster
PET semi-quantitative methods such as relative uptake value can be robust but offer no biological information and do not account for intra-subject variability in tracer administration or clearance. Simultaneous multimodal measurements that combine PET and MRI not only permit crucial multiparametric measurements, it provides means of applying tracer kinetic modelling without the need for serial...
Dmitry Philippov
(National Research Nuclear University MEPhI (Moscow Engineering Physics Institute))
5/19/15, 4:00 PM
4 - Advances in MR-SPECT instrumentation
Poster
A full-body gamma-camera based on SiPM readout is currently under development as a part of MEPHI R&D activity supported in the framework of Russian Megagrants program. A goal of this development is a fast upgrade of existing medical equipment with minor changes in a system design and construction in order to combine SPECT and MR instruments.
A monolithic NaI(Tl) scintillator commonly used...
Andrei Iagaru
(Stanford University)
5/19/15, 4:00 PM
7 - Clinical MR-PET
Poster
Aim: Here we evaluated the potential of TOF PET/MRI to reduce various PET image artifacts, by comparing the images to non-TOF PET/MRI, TOF PET/CT and non-TOF PET/CT.
Methods and materials: All patients underwent a single-injection of FDG, followed first by PET-CT and subsequently by PET-MRI scan. The PET/CT exams were performed using a GE Discovery 690 PET/CT scanner The PET/MRI images were...
Juergen Scheins
(Forschungszentrum Juelich GmbH)
5/19/15, 4:00 PM
3 - Advances in MR-PET and MR-SPECT software and quantification
Poster
Fast PET image reconstruction algorithms usually use a Line-of-Response (LOR) preprocessing step where the detected raw LOR data are interpolated either to evenly spaced sinogram projection bins or alternatively to a generic projection space as for example proposed by the PET Reconstruction Software Toolkit (PRESTO) [1]. In this way, speed-optimised, versatile geometrical projectors can be...
