Conveners
Session 11 - Poster Session II
- Dennis Schaart (Delft University of Technology)
- Christoph Lerche (Forschungszentrum Jülich GmbH)
Dr
Sandip Biswal
(Stanford University)
20/05/2015, 11:00
7 - Clinical MR-PET
Poster
The chronic pain sufferer is currently faced with a lack of objective tools to identify the source of their pain. The overarching goal is to develop clinical [18F]FDG PET/MRI methods to more accurately localize sites of increased neuronal and muscular metabolism or inflammation as it relates to neurogenic sources of pain and to ultimately improve outcomes of chronic pain sufferers. The aims...
Jorge Cabello
(Nuklearmedizinische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, Munich, Germany),
Negar Omidvari
(Nuklearmedizinische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, Munich, Germany)
20/05/2015, 11:00
5 - Preclinical MR-PET
Poster
MADPET4 is a high resolution PET insert under development for use in a 7 T MR. To fully exploit the capabilities of the insert, a good understanding of the physical interactions, which take place in the active and passive components of the insert, is necessary. The goal of this study was to investigate the effects of different physical interactions in an accurate model of MADPET4 using Monte...
Marco Bettiol
(Dept. of Molecular Medicine, Sapienza University of Rome)
20/05/2015, 11:00
1 - Advances in MR-PET instrumentation: detectors
Poster
The MindView European Project pursues the development of a high efficiency and high resolution brain dedicated PET detector, simultaneously working with a Magnetic Resonance Imaging (MRI) system. Since the PET scanner is based on a small diameter ring and on thick monolithic scintillation crystals to assess high efficiency, the parallax error related to off-center positron annihilation is a...
Prof.
Wai-Hoi Wong
(University of Texas MD Anderson Cancer Center)
20/05/2015, 11:00
1 - Advances in MR-PET instrumentation: detectors
Poster
Conventional dual-end depth-of-interaction (DOI) PET detector readout requires two 2D SiPM arrays; with top and bottom SiPM reading the same pixel, there is information redundancy. We proposed a dichotomous-orthogonal-symmetric (DOS) dual-end DOI readout to eliminate this redundancy to significantly reduce SiPM usage, electronic channels, and heat load. Reflecting films are used within the...
Mr
Amine Samoudi
(Ghent University/iMinds), Ms
Karen Van Audenhaege
(MEDISIP, IBBT-IBiTech, Ghent University)
20/05/2015, 11:00
4 - Advances in MR-SPECT instrumentation
Poster
SPECT and MRI each have their respective advantages and limitations. Combining these two technologies in a synergistic manner allows researchers to exploit the strengths of both techniques but also result in disturbing eddy currents. In this paper, we studied the temporal variation of the induced magnetic field due to the transverse and longitudinal gradient coils, in a full-ring multi-pinhole...
Ms
Tânia F. Vaz
(Institute of Biophysics and Biomedical Engineering of the Faculty of Sciences of the University of Lisbon, Lisboa, Portugal / Lisbon School of Health Technology of the Polytechnic Institute of Lisbon, Lisboa, Portugal)
20/05/2015, 11:00
3 - Advances in MR-PET and MR-SPECT software and quantification
Poster
Alzheimer Disease (AD) is characterized by progressive cognitive decline and dementia. Earlier diagnosis and classification of different stages of the disease are currently the main challenges and can be assessed by neuroimaging. With this work we aim to evaluate the quality of brain regions and neuroimaging metrics as biomarkers of AD.
Multimodal Imaging Brain Connectivity Analysis (MIBCA)...
Chang-Tong Yang
(Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore)
20/05/2015, 11:00
8 - Bimodal MR-PET tracers
Poster
Stable branched copolymer nanoparticles of varying size (Dh = 20 – 35 nm) have been developed and employed as MRI nano-sized contrast agents. RAFT polymerization has been employed to prepare these novel nanoparticles possessing DO3A macrocycles within their cores and succinimidyl ester benzoate functionalities within their coronas. It has been demonstrated that these nanoparticles can chelate...
Konstantinos Zeimpekis
(Nuclear Medicine, University Hospital Zurich)
20/05/2015, 11:00
7 - Clinical MR-PET
Poster
The recently available integrated PET/MR imaging can offer significant additional advances in clinical imaging. The purpose of this study was to compare the PET performance between a PET/CT scanner and an integrated TOF-PET/MR scanner concerning image quality parameters and quantification in terms of SUV as a function of acquisition time (a surrogate of dose).
Five brain and five whole body...
Dr
Frank Hofheinz
(Helmholtz-Center Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, PET Center)
20/05/2015, 11:00
3 - Advances in MR-PET and MR-SPECT software and quantification
Poster
Aim:
Recently, we have proposed a method for on-the-fly system matrix computation where the tube-of-response (TOR) is approximated as a cylinder with constant density (TOR-CD) and the cubic voxels are replaced by spheres. We could show that with this model the PET image quality can be notably improved compared to the vendor provided image reconstruction of our Philips Ingenuity-TF PET/MR....
Amine Samoudi
(Ghent University/iMinds)
20/05/2015, 11:00
4 - Advances in MR-SPECT instrumentation
Poster
We optimized the MR-compatibility of a novel tungsten collimator, produced with metal additive manufacturing that is part of a microSPECT insert for a preclinical SPECT/MRI scanner. We characterized the current density due to the gradient field and adapted the collimators by smart design to reduce the induced eddy currents.
The z-gradient coil and the collimator were modeled with SEMCAD....
David Douglas
(Stanford University, California, USA),
Eugene Wilson
(Stanford University), Prof.
Greg Zaharchuk
(Stanford University)
20/05/2015, 11:00
7 - Clinical MR-PET
Poster
Background: Regional hypoperfusion on Arterial Spin Labeling (ASL) MRI and corresponding regions of hypometabolism on FDG PET have been reported in Alzheimer’s Disease (AD). To our knowledge these correlations have not been studied under simultaneous acquisition. The purpose of this study is to investigate the correlation of ASL with FDG PET under simultaneous acquisition on PET-MR and to...
Dr
Hugo Ferreira
(2Institute of Biophysics and Biomedical Engineering, Faculty of Sciences of the University of Lisbon, Lisboa, Portugal.), Mr
Joao Leote
(1Department of Neurosurgery, Hospital Garcia de Orta, Almada, Portugal;2Institute of Biophysics and Biomedical Engineering, Faculty of Sciences of the University of Lisbon, Lisboa, Portugal), Prof.
Rita Nunes
(2Institute of Biophysics and Biomedical Engineering, Faculty of Sciences of the University of Lisbon, Lisboa, Portugal)
20/05/2015, 11:00
7 - Clinical MR-PET
Poster
Recently, DKI-based tractography has been developed, showing improved crossing-fiber resolution in comparison to deterministic DTI-based tractography in healthy subjects. In this work, DTI and DKI-based tractography methods were compared regarding the assessment of the corticospinal tract in patients presenting space-occupying brain lesions near cortical motor areas. Nine patients (4...
Ms
Vânia Tavares
(Institute of Biophysics and Biomedical Engineering, Faculty of Sciences of the University of Lisbon, Lisboa, Portugal)
20/05/2015, 11:00
7 - Clinical MR-PET
Poster
Epilepsy is one of the most important chronic neurological disorders worldwide affecting more than 50 million people of all ages. Among these, almost 20% of epilepsy cases are uncontrollable and have an unknown source of this abnormal electrical activity.
Present techniques for the detection of epileptogenic foci include electroencephalography (EEG), positron emission tomography, and...
Ana Mota
(Instituto de Biofísica e Engenharia Biomédica, FC-UL, Lisboa, Portugal; Institute of Nuclear Medicine, UCL, London, UK)
20/05/2015, 11:00
3 - Advances in MR-PET and MR-SPECT software and quantification
Poster
The Partial Volume (PV) effect in Positron Emission Tomography (PET) imaging leads to loss in quantification accuracy, which manifests in PV effects (small objects occupy partially the sensitive volume of the imaging instrument, resulting in blurred images). Simultaneous acquisition of PET and Magnetic Resonance Imaging (MRI) produces concurrent metabolic and anatomical information. The latter...
Mr
Niccolo' Camarlinghi
(Universita' di Pisa)
20/05/2015, 11:00
1 - Advances in MR-PET instrumentation: detectors
Poster
The TRIMAGE consortium aims to develop a multimodal PET/MR/EEG brain scanner dedicated to the early diagnosis of schizophrenia and other mental health disorders.
The PET component features a full ring made of 18 detectors, each one consisting of twelve 8x8 Silicon PhotoMultipliers (SiPMs) tiles coupled to two segmented LYSO crystal matrices with staggered layers.
In each module, the...
Peter Fischer
(Heidelberg University)
20/05/2015, 11:00
1 - Advances in MR-PET instrumentation: detectors
Poster
We present the first results of timing and energy resolution of two newly developed tiles based on FBK RGB-HD SiPMs. The first tile has dimensions of 32x32 mm2 and is composed of 8x8 SiPMs, with a regular pitch of 4 mm and a cell size of 25x25 µm2. Although manufactured with a standard bond wire technology, the tile achieves a fill factor at the tile level of 85%. We produced two versions: one...
Dr
Ekaterina Mikhaylova
(MEDISIP, Departement of Electronics and Information Systems, Ghent University-iMinds Medical IT.)
20/05/2015, 11:00
2 - Advances in MR-PET instrumentation: systems
Poster
A potential design for a high-resolution, ultralow-dose multimodal PET insert for pediatric medicine is presented. Several new technologies are combined to develop a unique, mobile, CT- and MRI-compatible PET system. The system is intended for diagnosis, staging, monitoring, and follow-up in the treatment of cancer as well as cardiac and neurological diseases, inflammation, and hyperinsulinism...
Penelope Bouziotis
(National Center for Scientific Research "Demokritos")
20/05/2015, 11:00
8 - Bimodal MR-PET tracers
Poster
Aim
Gadolinium chelate coated gold nanoparticles (Au@DTDTPA) can be applied as contrast agents for both in vivo X-ray and magnetic resonance imaging. In this work, our aim was to radiolabel and evaluate this gold nanoparticle with Ga-68, in order to produce a dual modality PET/MRI imaging probe.
Materials and Methods
For a typical preparation of 68Ga-labeled nanoparticles, the Au@DTDTPA ...
Christian Ritzer
(Department of Physics of Molecular Imaging Systems, Institute for Experimental Molecular Imaging, RWTH Aachen University, Aachen, Germany)
20/05/2015, 11:00
1 - Advances in MR-PET instrumentation: detectors
Poster
In order to further understand the PET/MRI scanner of our group, we measured the point spread function of a preclinical scintillation
crystal array with a pitch of 1 mm and a total size of 30 mm × 30 mm × 12 mm. It is coupled via a lightguide to a dSiPM from Philips Digital Photon
Counting, used on the TEK-setup. Crystal identification is done with a centre of gravity algorithm and the whole...
Mr
Chang-Han Huang
(National Taiwan University)
20/05/2015, 11:00
3 - Advances in MR-PET and MR-SPECT software and quantification
Poster
The hybrid positron emission tomography/computed tomography (PET/CT) or positron emission tomography/magnetic resonance imaging (PET/MRI) has become routine practice in clinics. The applications of multi-modality imaging can also benefit research advances. Consequently, dedicated small-imaging system like dual-head small-animal PET (DHAPET) that possesses the advantages of high detection...
Mr
Hadi Fayad
(INSERM, UMR 1101)
20/05/2015, 11:00
3 - Advances in MR-PET and MR-SPECT software and quantification
Poster
Aim: Respiratory and cardiac motion in PET/MR imaging leads to reduced quantitative and qualitative image accuracy. Correction methodologies involve the use of double gated acquisitions which lead to low signal-to-noise ratio (SNR) and to issues concerning the combination of cardiac and respiratory frames. The objective of this work is to use a generalized reconstruction by inversion of...
Florian Monnier
(LaTIM UMR 1101)
20/05/2015, 11:00
3 - Advances in MR-PET and MR-SPECT software and quantification
Poster
Aim:
Simultaneous PET/MR acquisition shows promise in a range of applications. Simulation using GATE is an essential tool that allows obtaining the ground truth for such acquisitions and therefore helping in the development and the validation of innovative processing methods such as PET image reconstruction, attenuation correction and motion correction. The purpose of this work is to validate...
Dr
Ryogo Minamimoto
(Stanford University, Department of Radiology, Division of Nuclear Medicine and Molecular Imaging)
20/05/2015, 11:00
6 - Whole-body and dedicated organ MR-PET
Poster
Purpose: Recently, a whole-body, simultaneous positron emission tomography - magnetic resonance imaging (PET-MRI) system combing MRI with time-of-flight (TOF) PET has been developed. We present our initial experience with human clinical studies using 18F-fluorodeoxyglucase (FDG) with this scanner, in comparison to PET-CT.
Methods: All patients underwent a single-injection of 18F-FDG, with a...
