May 17 – 20, 2015
La Biodola, Isola d'Elba
Europe/Rome timezone

Do Carotid MR Surface Coils Affect PET Quantification in PET/MR Imaging?

May 19, 2015, 12:00 PM
15m
Room Maria Luisa

Room Maria Luisa

Talk 3 - Advances in MR-PET and MR-SPECT software and quantification Session 6 - Whole-body and dedicated organ MR-PET

Speaker

Martin J Willemink (Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York)

Description

Aim To evaluate the effect of surface coils for carotid MR imaging on PET quantification in a clinical simultaneous whole-body PET/MR scanner. Methods and materials A cylindrical phantom was filled with a homogeneous 2L water-FDG mixture at a starting dose of 301.2MBq. Clinical PET/MR and PET/CT systems were used to acquire PET-data without a coil (reference standard) and with two carotid MRI coils (Siemens Special Purpose 8-Channel and Machnet 4-Channel Phased Array). PET-signal attenuation was evaluated with Osirix using 51 (PET/MR) and 37 (PET/CT) circular ROIs. Mean and maximum standardized uptake values (SUVs) were quantified for each ROI. Furthermore, SUVs of PET/MR and PET/CT were compared. For validation, a patient was scanned with an injected dose of 407.7MBq on both a PET/CT and a PET/MR system without a coil and with both coils. Results PET/MR underestimations were -2.2% (Siemens) and -7.8% (Machnet) for SUVmean, and -1.2% (Siemens) and -3.3% (Machnet) for SUVmax, respectively. For PET/CT, underestimations were -1.3% (Siemens) and -1.4% (Machnet) for SUVmean and -0.5% (both Siemens and Machnet) for SUVmax, respectively using no coil data as reference. Except for PET/CT SUVmax values all differences were significant. SUVs differed significantly between PET/MR and PET/CT with SUVmean values of 0.51-0.55 for PET/MR and 0.68-0.69 for PET/CT, respectively. The patient examination showed that median SUVmean values measured in the carotid arteries decreased from 0.97 without a coil to 0.96 (Siemens) and 0.88 (Machnet). Discussion - Conclusion Carotid surface coils do affect attenuation correction in both PET/MR and PET/CT imaging. Furthermore, SUVs differed significantly between PET/MR and PET/CT.

Primary author

Martin J Willemink (Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York)

Co-authors

Dr Mootaz Eldib (Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA) Prof. Tim Leiner (Department of Radiology, University Medical Center Utrecht, The Netherlands) Dr Venkatesh Mani (Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA) Prof. Zahi A Fayad (Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA)

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