Dr
Gabriella Rainaldi
(Istituto Superiore di Sanitร , Department of Hematology, Oncology and Molecular Medicine)
18/10/2012, 16:15
Other
poster preferred
Exosomes are small membrane vesicles secreted by a variety of cell types into the extracellular environment. They have also been isolated from numerous body fluids such as plasma, serum and urine. Their presence in biological fluids suggests their involvement in diverse physiological and/or pathological events. In particular, it has been indicated that exosomes could be carriers for...
Prof.
Marek K. Janiak
(Military Institute of Hygiene and Epidemiology)
18/10/2012, 16:16
Radiation Carcinogenesis
poster preferred
BALB/c mice are more sensitive to ionizing radiation than C57BL/6 mice, the latter being regarded as the relatively radioresistant strain. Likewise, the incidence of cancer following absorption of medium doses of low-LET radiation is more frequent in the former compared to the latter mice. In this study we evaluated the effects of fractionated X-ray exposure of mice from the two strains on...
114.
Unraveling radon-related lung cancer mortality risks affected by smoking: a WISMUT cohort study
Dr
Teun van Dillen
(National Institute for Public Health and the Environment (RIVM))
18/10/2012, 16:17
Radiation Carcinogenesis
poster preferred
We have developed a technique to account for missing information on smoking habits in the quantification of lung-cancer risks related to the exposure to radon and its progeny. Such risk calculations are often based on epidemiological miner-cohort studies, but contrary to the exposures to radon, cohort-wide information on the tobacco consumption โ a crucial factor in lung-cancer induction โ is...
Dr
Galina Rusinova
(Southern Urals Biophysics Institute)
18/10/2012, 16:18
Radiation Carcinogenesis
poster preferred
Internal exposure to alpha-particle radiation from incorporated Pu-239 increases the risk of lung cancer. Studies including complex approaches on revelation gene alterations at different cancer stages are perspective. Tumor suppressor gene p53 is one of the most important gene regulating cellular cycle. Alterations of gene p53 play an important role in human carcinogenesis, and are observed...
Ms
Julia Hess
(Research Unit of Radiation Cytogenetics, Helmholtz Zentrum Mรผnchen, German Research Center for Environmental Health, Neuherberg, Germany)
18/10/2012, 16:19
Radiation Carcinogenesis
poster preferred
The main consequence of the Chernobyl accident has been an increase in childhood papillary thyroid carcinomas (PTC) in the contaminated areas. Consequently, we aimed to identify genomic radiation biomarkers.
Within the EU-funded project GENRISK-T we analysed 80 PTC from patients that were matched for age at diagnosis, sex and residence. DNA and RNA from the tumours were provided by the...
Dr
Mirella Tanori
(Laboratory of Radiation Biology and Biomedicine, Agenzia Nazionale per le Nuove Tecnologie, l'Energia e lo Sviluppo Economico Sostenibile (ENEA) CR-Casaccia)
18/10/2012, 16:20
Radiation Carcinogenesis
poster preferred
Cancer risk deriving from in utero exposure to ionizing radiation is an important and unresolved issue of radiation protection, as clear-cut conclusion on the estimated excess relative risk of childhood cancer has not been reached.
Experimental studies conducted on sensitive models of radiation-induced pediatric tumors may be useful helping to improve mechanistic understanding and...
Mr
Lucas Burigo
(Frankfurt Institute for Advanced Studies, J.-W. Goethe-University, 60438 Frankfurt am Main, Germany)
18/10/2012, 16:21
Charged Particles in Medicine and Space Research
poster preferred
Presently protons and 12C nuclei are successfully used for treating cancer. Other projectiles, e.g. 4He and 7Li, differ in their biological action from 12C nuclei, but still have favourable beam divergence similar to 12C and thus can be considered as new treatment options. In view of possible applications of nuclei lighter than carbon in cancer therapy, the quality of their radiation fields...
Dr
Thomas Ernst Schmid
(Technische Universitรคt Mรผnchen, Germany)
18/10/2012, 16:22
Charged Particles in Medicine and Space Research
poster preferred
Purpose: We investigate the use of a microchannel proton irradiation, which is a matrixwise application of a proton microbeam for tumor therapy. It minimizes the risk of normal tissue damage in radiation therapy of tumors while keeping tumor control as for conventional broad beam irradiation due to the lateral scattering of the protons on their way to the tumor.
Methods: Microbeam...
Dr
Ainars Bajinskis
(Stockholm University)
18/10/2012, 16:23
Other
poster preferred
In the last decade studies have shown that unique gene and protein expressions are induced in response to low doses (in the range of 10 โ 100 mGy) compared to high doses (1 to 4 Gy) of ionising radiation. Studies showed that different numbers of genes or proteins are altered in response to radiation and only a small number of genes or proteins were the same for low and high doses.
We aimed...
Dr
Peter Peschke
(Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany)
18/10/2012, 16:24
Charged Particles in Medicine and Space Research
poster preferred
Introduction: Carbon ion radiotherapy enables the highly conformal treatment of deep-seated tumors due to the finite range and the inverted depth dose profile of charged particles. This physical advantage goes along with a higher linear energy transfer (LET) in the Bragg-peak as compared to the beam entrance region and results in an increase of the relative biological effectiveness (RBE)...
Dr
Yoshitaka Matsumoto
(National Institute of Radiological Sciences)
18/10/2012, 16:25
Charged Particles in Medicine and Space Research
poster preferred
[Background and Purpose] The fractionated irradiation is standard protocol for radiotherapy including carbon-ion beam (C-ions) therapy. There are big differences between single and fractionation, for example on DNA damage repair, reoxygenation of hypoxic region, etc. It is necessary to get the results using fractionated irradiation to know the effects in clinical. The purpose of this study is...
Dr
Ryoichi Hirayama
(NIRS/National Institute of Radiological Sciences)
18/10/2012, 16:26
Charged Particles in Medicine and Space Research
poster preferred
The contribution of indirect action mediated by OH radicals in cell killing can be estimated from the experiment using an OH radical scavenger DMSO, which suppresses indirect action without affecting direct action. Exponentially growing Chinese hamster ovary cells under oxic and hypoxic conditions were exposed to X-rays and high-LET heavy ion radiations of 15 to 480 keV/micrometer in the...
Mr
Marco Lavagno
(DE.TEC.TOR. SRL (a Torino University spin-off company))
18/10/2012, 16:27
Charged Particles in Medicine and Space Research
poster preferred
Keywords: beam monitors, hadrontherapy, multilayer ionization chamber
On October 2009 DE.TEC.TOR. s.r.l. (Devices & Technologies Torino) was founded as a spin-off company of University of Torino and it is in the process of becoming a spin-off of the Italian Institute of Nuclear Physics (INFN).
The business of DE.TEC.TOR. is to produce beam delivery monitors (pixel and strip ionization...
Maria Adelaide Garella
(Fondazione CNAO- INFN Sez. TO)
18/10/2012, 16:28
Charged Particles in Medicine and Space Research
poster preferred
Purpose: Centro Nazionale di Adroterapia Oncologica (CNAO) is treating patients since September 2011, with a 3D active beam delivery system, which irradiates the tumor using a large number of beam spots. The first treatments were performed with protons while the commissioning phase is ongoing with carbon ion beam. In vitro and in vivo experiments with carbon have been performed and the...
Dr
Ekaterina Koryakina
(Medical Radiological Research Center)
18/10/2012, 16:29
Other
poster preferred
Cytogenetic studies of a new neutron device ING-031, pulsed neutron generator with sealed tube, were carried out using G0 human lymphocytes as a test-system. The generator produced (D,T) neutrons with the energy of 14 MeV at the frequency of 1-100 Hz. Samples of whole blood were irradiated in stacked up glass Carrel flasks under proton equilibrium conditions. Thus, all samples were irradiated...
Ms
Julie Constanzo
(IPNL, Universitรฉ de Lyon, Universitรฉ Lyon1, CNRS/IN2P3, 4, rue Enrico Fermi, 69622 Villeurbanne Cedex, France)
18/10/2012, 16:30
Charged Particles in Medicine and Space Research
poster preferred
A horizontal beam facility for radiobiological experiments with medium-energy protons has been setup at the 4MV Van de Graaff accelerator of the Institut de Physique Nuclรฉaire de Lyon. At this energy, the Relative Biological Effectiveness (RBE) of protons may amount to 2-7 [Belli 1998], platform constitutes thus a tool to study the specific effects of high-LET radiations to cells. For such...
Dr
Jin Kyu Kim
(Korea Atomic Energy Research Institute)
18/10/2012, 16:31
Non-Cancer Effects
poster preferred
There are several lines of experimental proof that nanoparticles (NPs) have toxicity on various organisms. In general, NPs are defined as particles having one dimension below 100 nm. It has been reported that both TiO2 and ZnO NPs had toxicity to several prokaryotic cells such as and gram-negative Escherichia coli and gram-positive Basillus subtilis. In the meanwhile, ionizing radiation...
Mrs
Arundhathi Sriharshan
(Helmholtz Center Munich)
18/10/2012, 16:32
Non-Cancer Effects
poster preferred
Epidemiological data show that ionising radiation increases the risk of cardiovascular disease. The endothelium is one of the main targets of radiation-induced damage. Rapid radiation-induced alterations in the biological processes were investigated after exposure to a clinically relevant radiation dose (2.5 Gy gamma radiation). The changes in protein expression were determined using the human...
Dr
Harmen Bijwaard
(RIVM - National Institute for Public Health and the Environment)
18/10/2012, 16:33
Charged Particles in Medicine and Space Research
poster preferred
Mechanistic models may help to determine how ionising radiation promotes the development of atherosclerosis. For this purpose a model has been formulated that allows for radiation to contribute to the process of atherosclerosis in several ways. The model is based on what is known from the scientific literature on plaque formation and the possible influences of radiation on this process. The...
Dr
Montserrat Bellรฉs Mateu
("Rovira i Virgili" University)
18/10/2012, 16:34
Non-Cancer Effects
poster preferred
Twenty six years after the accident of the Chernobyl nuclear power plant, some populations are still exposed to chronic low dose of 137Cs, mainly through the diet. Moreover, people can also be contaminated with low doses of external ionising radiation. The health effects of a combination of internal and external exposure to low doses of radiation are still uncertain.
The aim of this study was...
Ms
Daisy Lafuente
("Rovira i Virgili" University)
18/10/2012, 16:35
Non-Cancer Effects
poster preferred
In nuclear power plants accidents, such as Chernobyl or Fukushima, fission-product radioisotopes (137Cs, 90Sr, 239Pu and 131I) are released to the atmosphere. These radioactive compounds contaminate extended field areas and groundwater. As a result of these incidents, the population are exposed to external and internal ionising radiation.
The brain is highly sensitive to ionising radiation...
Dr
Louis de Saint-Georges
(SCK-CEN)
18/10/2012, 16:36
Non-Cancer Effects
poster preferred
Seeing the increasing use of nuclear power, planning of long term space missions, occupational and medical exposures, knowledge about health effects related to chronic low dose exposure are of importance. Recent epidemiological studies indicate an increased risk of cardiovascular diseases at low doses, however a comprehensive understanding of the underlying biological and molecular mechanisms...
Ms
Hussain Shahana
(Department of Genetics, University of Leicester, Leicester LE1 7RH, UK)
18/10/2012, 16:37
DNA Damage and Repair
poster preferred
Radiotherapy (RTH) has a key role in breast cancer (BC) treatment. Studies have shown BC survivors have an excess risk of significant cardiovascular (CV) morbidity 10 years post-treatment, with similar features of an older unirradiated population. One of the underlying mechanisms is thought to be premature CV ageing. We aim to develop a novel biomarker to detect radiation exposure and...
Katalin Lumniczky
(National Research Institute for Radiobiology and Radiohygiene, Budapest, Hungary)
18/10/2012, 16:38
Non-Cancer Effects
poster preferred
Background: Central nervous system toxicity after high doses of irradiation is well documented. The biological effects of low doses are far less known. Accumulating data show, that low-dose irradiation might increase the incidence of ischemic cardiovascular diseases and the mechanisms by which this occurs is under intense investigation. However, much less attention is paid to low-dose...
Dr
Mariateresa Mancuso
(ENEA CR Casaccia)
18/10/2012, 16:39
Non-Cancer Effects
poster preferred
Cataract (the opacification of the ocular lens) is the most frequent cause of blindness worldwide. The eye is well known to be one of the most radiosensitive tissues in the body and is clearly recognized that cataracts can be induced by high doses (>2 Gy) of ionizing radiation. Although much work has been carried out in this area, the exact mechanisms of radiation cataractogenesis are still...
Dr
Alexander Shakhov
(Cleveland BioLabs, Inc.)
18/10/2012, 16:40
Radioecology
poster preferred
It has been demonstrated previously that Salmonella flagellin derivative CBLB502 may serve as an excellent radiation countermeasure if administered in a protective regimen. Flagellin/CBLB502-elicited radioprotection required TLR5 and the TLR signaling adaptor MyD88. Radioprotection was, at least in part, mediated via direct effects CBLB502 on cells in bone marrow. It was well documented that...
Dr
Michal Hofer
(Laboratory of Experimental Hematology, Institute of Biophysics, v.v.i., Academy of Sciences of the Czech Republic)
18/10/2012, 16:41
Modulation of Radiosensitivity
poster preferred
IB-MECA, an adenosine receptor agonist selective for adenosine A3 receptors, was tested from the point of view of its abilities to influence hematopoiesis in sublethally gamma-irradiated mice and survival of lethally irradiated ones. The drug was administered in therapeutic (post-irradiation) treatment regimens. After a sublethal radiation dose of 4 Gy, IB-MECA was found to stimulate...
Dr
Jacek Rogolinski
(Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology)
18/10/2012, 16:42
Modulation of Radiosensitivity
poster preferred
Jacek Rogoliลski1, Maria Konopacka1, Aleksandra Rusin 1, Krzysztof ลlosarek2
Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice, Poland
1Center for Translational Research and Molecular Biology of Cancer
2 Department of Radiotherapy and Brachytherapy Treatment Planning
Cancer radiotherapy regimens use radiation of varying dose rates (100 โ 600...
Dr
Maria Konopacka
(Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Center for Translational Research and Molecular Biology of Cancer)
18/10/2012, 16:43
Modulation of Radiosensitivity
poster preferred
In the presented study, electron radiation (22 MeV) dose distribution in a water phantom was compared with biological effects (formation of micronuclei and induction of apoptosis) in irradiated cells. The influence of antioxidants on radiation โ induced genetic damage during radiation therapy was also tested.
Experiments were performed using normal bronchial epithelial cells (BEAS-2B) and...
Dr
Shinji Kariya
(Department of Diagnostic Radiology and Radiation Oncology, Kochi Medical School)
18/10/2012, 16:44
Modulation of Radiosensitivity
poster preferred
Purpose: We previously reported that hydrogen peroxide (H2O2) strongly enhanced radiation-induced apoptosis in PC-3 human prostate cancer cell line, that this apoptosis was lysosome dependent, and that mitochondria existed downstream of lysosomes in the apoptotic pathway (IJROBP75: 449-454, 2009). In this study, we studied how H2O2 affected radiation-induced apoptosis in the PC-3 human...
Mr
Sundarraj Jayakumar
(Radiation Biology and Health Sciences Division, Bhbha Atomic Research Centre, Mumbai, India)
18/10/2012, 16:45
Modulation of Radiosensitivity
poster preferred
Understanding about the genes which govern tumor radiosensitivity, can help in better selection of patients for radiotherapy protocols, predicting prognosis, and perhaps in decreasing therapy-related side effects. In order to study the molecular determinants of tumor radiosensitivity, we have chosen two prostate tumor cells namely, PC-3 and DU145. These two tumor cell lines showed significant...
Prof.
Woo-Yoon Park
(Chungbuk National University, Cheongju, Korea)
18/10/2012, 16:46
Modulation of Radiosensitivity
poster preferred
Fused Toes Homolog (FTS) is a member of a group of proteins termed as E2 variants and this group of proteins lacks an active cysteine residue that is required for ubiquitin transfer. We have identified the expression of this protein in early stages of cervical cancer and its translocation into nucleus from cytoplasm upon irradiation. Also nuclear localization of FTS upon irradiation is...
Dr
Aneta Cheda
(Military Institute of Hygiene and Epidemiology)
18/10/2012, 16:47
Modulation of Radiosensitivity
poster preferred
Disorders caused by the short-term absorption of moderate-to-high doses of ionizing radiation are often associated with suppressed heamatopoiesis as well as primary and secondary inflammation and thrombosis. Nicotinamide (NA), a derivative of nicotinic acid (NAc) and a precursor of nicotinamide adenine dinucleotide (NAD+), is metabolized in the body to 1-methylnicotinamide (MNA) which exerts...
Dr
Jae-Hoon Jeong
(Korea Institute of Radiological and Medical Sciences), Dr
Young-Joo Shin
(Inje University Sanggye Paik Hospital)
18/10/2012, 16:48
Modulation of Radiosensitivity
poster preferred
Objectives: To improve the chemoradiotherapy efficacy in cancer patients by investigating the biological function of HMGB2 with respect to radiation response regulation.
Methods: HMGB2 gene knockdown cells were constructed by infecting shRNA expressing lentivirus. mRNA expression was measured by realtime qRT-PCR and protein level or phosphorylation was by Western blot analysis. Clonogenic...
Dr
Kwang Hee Yang
(Korea Hydro & Nuclear Power co. LTD.)
18/10/2012, 16:49
Modulation of Radiosensitivity
poster preferred
The biological effects of low dose ionizing radiation (LDIR) remain insufficiently understood. In our previous study, Ikaros was phosphorylated in response to LDIR in IM-9 B lymphoblasts cell line. Ikaros encodes a zinc finger transcription factor that is an important regulator of a hematopoietic stem cells (HSCs) progression in the B lymphoid lineage development, differentiation and...
Dr
Anne Kraemer
(Institute of Radiation Biology, Helmholtz Center Munich, Germany)
18/10/2012, 16:50
Modulation of Radiosensitivity
poster preferred
Due to the damage incurred by normal tissue, especially the endothelium, radiation doses used in tumour therapy are limited. A better understanding of the processes governing the radiosensitivity of endothelial cells is therefore desirable for improved radiation therapy. We have previously demonstrated that the sensitivity of endothelial cells to ionizing radiation depends on...
Dr
Tadashi Hongyo
(Osaka university)
18/10/2012, 16:51
Modulation of Radiosensitivity
poster preferred
Irradiation in radiation therapy or bone marrow transplantation is known to cause damage to normal tissues. Although some substances are reported to suppress the damage(=radioprotectors), most of them have strong side effects and are not applicable in vivo. However, ascorbic acid and AHCC (Active Hexose Correlated Compound) are known as safe radioprotectors with antioxidant activity. While...
Dr
Verena Zangen
(Helmholtz Zentrum Mรผnchen, German Research Centre for Environmentel Health, Research Unit of Radiation Cytogenetics)
18/10/2012, 16:52
Modulation of Radiosensitivity
poster preferred
Besides surgery and chemotherapy, radiotherapy is one of the main treatment options of head and neck squamous cell carcinoma (HNSCC). Radiation resistance of some tumours causes local recurrences that go along with unfavourable prognosis. Therefore, the characterisation of the radiation response of tumour cells is a major issue for the development of personalised therapy strategies. The...
Lusine Zhamharyan
(dr)
18/10/2012, 16:53
Modulation of Radiosensitivity
poster preferred
L.G. Zhamharyan, T.Zh. Hovsepyan, E.A. Arakelova, V.A. Ayvazyan, A.S. Boyajyan
Institute of Molecular Biology, National Academy of Science of the Republic of Armenia
Numerous data have demonstrated the induction of apoptosis by ionizing radiation (IR) through activation of Bax signaling pathway. It has been also shown the key role of antioxidant enzymes, namely superoxide dismutase (SOD)...
Prof.
Irina Zamulaeva
(Medical Radiological Research Center of the Ministry of Health of the Russian Federation)
18/10/2012, 16:54
Modulation of Radiosensitivity
poster preferred
CD34+ hematopoietic stem cells (HSC) are known to migrate from bone marrow into peripheral blood and tumor tissue under the influence of variety of factors produced by the last one. One can suppose that HSC are capable to render considerable influence on cancer progression and efficiency of treatment through inhibition of intratumoral T-lymphocytes, differentiation into dendritic and...
Ms
Olga Matchuk
(Medical Radiological Research Center of the Ministry of Health of the Russian Federation)
18/10/2012, 16:55
Stem Cells Radiobiology
poster preferred
Cancer stem cells (CSC), detected in variety of tumor types and cancer cell lines, were shown to be more resistant to the low-LET radiation in comparison to the other cancer cells. CSC are supposed to determine long-term efficiency of cancer therapy. Therefore, exploration of regularities and mechanisms of CSC radio- and chemosensitivity is of great interest at present. The aim of this...
Mr
Andrey Akleyev
(Urals Research Center for Radiation Medicine)
18/10/2012, 16:56
Stem Cells Radiobiology
poster preferred
Modification of Immunity in Individuals with Late Radiation-Induced Neutropenia Using Hemopoietic Cells of Fetal Liver
A. Akleyev, I. Dolgushin, G. Dimov
The objective of the study was to assess the effect of hemopoietic cells of fetal liver (HC FL) on the key characteristics of innate immunity in persons who developed neutropenia at late time after a long-term chronic radiation...
Elza Sakamoto-Hojo
(Department of Genetics, Faculty of Medicine of Ribeirรฃo Preto-USP)
18/10/2012, 16:57
Stem Cells Radiobiology
poster preferred
Glioblastoma multiforme (GBM) is among the most lethal of all human tumors, and radiotherapy remains one of the main treatment, besides surgery and chemotherapy. New strategies and Improvements in the therapies are required to overcome the cellular resistance of GBM. The identification of transcription factors (TFs) associated with significantly modulated genes in irradiated GBM could give...
