Irina Soboleva
(ITEB RAS)
18/10/2012, 13:30
Modulation of Radiosensitivity
oral (travel award)
Ionizing radiation (IR) is used for radiotherapy of different cancer diseases including lung cancer. This pathology extends to considerable part of working men decreasing quality of life.
Modern cancer treatments include the exposure at significant dose of IR. It's focused on local body area. Dose size depends on disease severity and health status of the patient. But medical regimen is very...
Mr
Sebastian Kuger
(Department of Radiation Oncology, University Würzburg)
18/10/2012, 13:45
Modulation of Radiosensitivity
oral (travel award)
In its function as an ATP-dependent molecular chaperone the heat shock protein 90 (Hsp90) facilitates the correct folding and maintenance of other proteins, commonly known as Hsp90 clients. These clients include many oncogenic proteins, as transcription factors, growth factor receptors, steroid hormone receptors and various signaling proteins. Protein stability is hampered in solid tumors, due...
Dr
Stanislav Vasilyev
(Institute of Medical Genetics, Tomsk, Russia)
18/10/2012, 14:00
DNA Damage and Repair
oral (travel award)
Effects of ionizing radiation registered in cells after low dose irradiation are still poorly understood. In several studies both direct and reverse effects of dose and dose rates observed in this dose range. Pulsed mode of irradiation is a useful way to understand not only the effects of dose and dose rate but also to distinguish between effects of dose rate within pulse and average dose rate...
Ms
Natalia Niewidok
(Department of Radiation Oncology, University Hospital Wuerzburg)
18/10/2012, 14:15
Modulation of Radiosensitivity
oral (travel award)
In previous studies we have described the radiosensitizing potential of novel heat shock protein 90 (Hsp90) inhibitors NVP-AUY922 and NVP-BEP800 in normoxic and hypoxic conditions (Stingl et al. 2010, Djuzenova et al. 2012). However, the therapeutic potential of Hsp90 inhibitor as a radiation sensitizer will strongly depend on a selective increase in the radiosensitivity of tumor cells over...
Dr
Francesco Berardinelli
(University of rome "roma Tre")
18/10/2012, 14:30
DNA Damage and Repair
oral (travel award)
Many and differents are the proposed mechanisms leading to resistance to ionizing radiation treatment. Among them, an inverse relationship between telomere length and radioresistance has been recently advanced. Investigating such a relationship in TK6 lymphoblasts, we found that clones originating from cells survived to 4 Gy of X-rays showed a significantly higher telomere length if compared...
Ekaterina Plyusnina
(Institute of Biology, Komi SC, UrB of RAS)
18/10/2012, 14:45
DNA Damage and Repair
oral (travel award)
The purpose of this research is to investigate the role of genes of DNA breaks recognition (ATM, ATR homologues), base and nucleotide excision repair (PCNA, XPC, XPF, Gadd45 homologues) and double-strand breaks repair (BLM, Rad50, Rad51, Rad54 homologues), and apoptosis (p53, Gadd45) in formation of specific long-term effects of chronic low-dose gamma-radiation in Drosophila melanogaster. The...
Ms
Svetlana Sorokina
(ITEB RAS)
18/10/2012, 15:00
Biological and Physical Dosimetry
oral (travel award)
In the present work we investigated the influence of low doses of high-LET radiation on the cytogenetic damage in bone marrow and thymus cells and solid tumor growth in mice and their offspring, using the radiosensitivity and “adaptive response” (AR) tests. Two-month-old SHK male mice were used. All groups of animals were exposed to doses of 0.17 – 30.8 cGy (1 cGy/day) in the radiation field...
Dr
Justyna Miszczyk
(Institute of Nuclear Physics PAN, Kraków, Poland)
18/10/2012, 15:15
Biological and Physical Dosimetry
oral (travel award)
Radiotherapy plays an important role in the treatment of many cancers. Therefore, there are many approaches and strong needs to establish the most appropriate method that would maximize efficiency of therapy and minimize the side effects and late health risk. It should also allow rapid and reliable screening of individuals and stratifications due to lower or upper radiosensitivity for modeling...
Ms
Julia Künzel
(Darmstadt University of Technology, Radiation Biology and DNA Repair, Darmstadt, Germany)
18/10/2012, 15:30
DNA Damage and Repair
oral (travel award)
Misrepair of DNA double-strand breaks (DSBs) can lead to chromosomal translocations, a driving force in carcinogenesis. DSBs induced by exogenous agents such as ionizing radiation (IR) are repaired with fast and slow components representing repair events in euchromatin and heterochromatin, respectively. The fast component involves canonical non-homologous end-joining (c-NHEJ) in G1- and...