Dr
Simona Pazzaglia
(Laboratory of Radiation Biology and Biomedicine, ENEA , Rome, Italy)
18/10/2012, 10:00
Radiation Carcinogenesis
oral (invited speaker)
Exposure to ionizing radiation produces deleterious consequences in humans, including cancer. Although quantitative radiation effects are well established at high doses, considerable uncertainties persist about radiation-induced cancer in the low-dose region. Given our current state of knowledge, the model applied by regulatory bodies is based on the evidence that DNA damage, causing mutation...
Prof.
Horst Zitzelsberger
(Helmholtz Zentrum München, Research Unit of Radiation Cytogenetics)
18/10/2012, 11:00
Radiation Carcinogenesis
oral (invited speaker)
Childhood thyroid carcinoma incidence is significantly increased after exposure to ionizing radiation. Such an increased thyroid cancer risk in children and adolescents has been observed after the Chernobyl accident in contaminated areas even at moderate or low doses of 150 mGy and below. So far, the molecular mechanisms underlying radiation-induced carcinogenesis in the thyroid gland have not...
Mr
Damien Drubay
(IRSN/PRP-HOM/SRBE/LEPID)
18/10/2012, 11:30
Radiation Carcinogenesis
oral (20 minutes)
Introduction: A significant excess of kidney cancer mortality risk was observed among French uranium miners, chronically exposed at ionizing radiations (IR). However this excess did not appear associated with radon exposure. This relationship is studied in German cohort, which is ten times larger than the French cohort.
Method: This cohort includes 58987 uranium miners, follow-up between...
Dr
Wolfgang Heidenreich
(Helmholtz Zentrum München, Neuherberg, Germany)
18/10/2012, 11:50
Radiation Carcinogenesis
oral (20 minutes)
We find evidence that the different susceptibility of BALB/C and CBA/Ca
mice to bone cancer after 227Thorium injection is mostly
due to different promotional responses to radiation. In BALB/C x CBA/Ca
back-crossed mice we analyzed the specific contribution of
two individual loci in the carcinogenic process. This analysis suggests
that the two high or low risk alleles are either acting...
Dr
Nobuyuki Hamada
(Radiation Safety Research Center, Nuclear Technology Research Laboratory, Central Research Institute of Electric Power Industry (CRIEPI), Tokyo 201-8511, Japan)
18/10/2012, 12:10
Radiation Carcinogenesis
oral (20 minutes)
Ionizing radiation is a well-known carcinogen, but the cell of origin (target cells) is still unidentified for radiation carcinogenesis. Whatever the nature of target cells, the irradiated tissue may accumulate radiation damage causing cancer, if the damaged target cells are not excluded from the tissue through its cell death or tissue turnover. The identification of target cells hence...
