Prof.
Kevin Prise
(Queen's University Belfast)
16/10/2012, 17:00
Non-Targeted Effects of Radiation
oral (invited speaker)
Our understanding of the mechanisms of radiation response in biological systems has been changing from studying the role of radiation damage at the DNA and cellular level to integrated models of tissue and whole organism responses. Key to this has been a growing appreciation of bystander responses where cells respond to their neighbours being irradiated and intercellular signalling mechanisms...
Dr
William F. Morgan
(Pacific Northwest National Laboratory, Richland, WA 99352, USA)
16/10/2012, 17:30
Non-Targeted Effects of Radiation
oral (invited speaker)
“Non-targeted effects” is an all embracing term to include biological effects observed in cells that were themselves not irradiated, but were the progeny of an irradiated cell, or received signals from an irradiated cell. These non-targeted effects include a variety of endpoints usually associated with exposure to ionizing radiation, e.g., chromosomal rearrangements, mutation induction and...
Mr
Sharath Sasi
(Tufts University)
16/10/2012, 18:00
Non-Targeted Effects of Radiation
oral (15 minutes)
Tumor necrosis factor(TNF) binds two receptors TNFR1/p55 and TNFR2/p75 and activates several signaling cascades. Ionizing radiation (IR) increases tissue levels of TNF. TNF signaling regulates numerous cytokines/chemokines that may mediate IR-induced non-targeted effects (NTE), a phenomenon where cells that are not directly “hit” by IR exhibit IR effects via signals received from distant IR...
Dr
Salomé PAILLAS
(IRCM, INSERM)
16/10/2012, 18:15
Non-Targeted Effects of Radiation
oral (15 minutes)
Objectives
The observation of radiation-induced bystander response has important implication for understanding the efficiency of radiotherapy particularly after low-dose exposure. We investigated the role of bystander phenomena in cells exposed to low-dose radioimmunotherapy (RIT) using 125I-monoclonal antibodies (mAb).
Methods: Contribution of bystander effects was assessed using standard...
Prof.
Alexey Moskalev
(Institute of biology of Komi Science Center of RAS)
16/10/2012, 18:30
Non-Targeted Effects of Radiation
oral (15 minutes)
Low doses of ionizing radiation induce a wide range of biological effects including hormesis, adaptive response and hypersensitivity that modulate lifespan. However, the molecular mechanisms underlying the lifespan effects of low-dose irradiation are poorly understood. DNA repair is one of the key mechanisms of cell response to different types of stress including ionizing radiation. The...
Mr
GABRIELE BABINI
(University of Pavia, Physics Department - INFN, Section of Pavia)
16/10/2012, 18:45
Non-Targeted Effects of Radiation
oral (15 minutes)
Background:
NF-κB transcription factors are critical regulators of immunity, stress responses, apoptosis and differentiation. A variety of stimuli coalesce on NF-κB activation. NF-κB-dependent transcription is not only tightly controlled by positive and negative regulatory mechanisms but also closely coordinated with other signaling pathways [1].
Indeed, the NF-kB pathway is activated in...
