Dr
Roberto Orecchia
(CNAO Centro Nazionale Adroterapia Oncologica, Pavia, Italy, and European Institute of Oncology, Milano, Italy)
18/10/2012, 10:00
Charged Particles in Medicine and Space Research
oral (invited speaker)
CNAO, Centro Nazionale di Adroterapia Oncologica, is the first hadrontherapy facility in Italy with both proton and carbon ion (maximum energy 400 MeV/u) therapeutic beams. It is equipped with three treatment rooms with fixed horizontal and vertical beam lines with active spot scanning dose delivery system. Patient treatment with protontherapy (PT) has started in September 2011 after physical...
Dr
Livio Narici
(Tor Vergata University, Roma, Italy)
18/10/2012, 11:00
Charged Particles in Medicine and Space Research
oral (invited speaker)
Radiation is a fundamental issue in preparing the near future human space exploration missions.
The knowledge of the cosmic radiation field characteristics in the environments where astronauts are going to live during their interplanetary voyages is a mandatory step towards the minimization of the radiation risks below acceptable thresholds. Most recent results from radiation biology ask for...
Dr
Marjan Moreels
(Radiobiology Unit, Belgian Nuclear Research Centre, SCK•CEN, Boeretang 200, 2400 Mol, Belgium)
18/10/2012, 11:30
Charged Particles in Medicine and Space Research
oral (15 minutes)
Hadrontherapy is a form of external radiation therapy, which uses beams of charged particles such as carbon ions. Compared to conventional X-ray therapy, the main advantage of hadrontherapy is the precise dose localization along with an increased biological effectiveness. This high ballistic accuracy allows depositing the maximal dose to the tumor, while damage to the surrounding healthy...
Dr
Lorenzo Manti
(University of Naples Federico II and INFN, Section of Naples, Italy)
18/10/2012, 11:45
Charged Particles in Medicine and Space Research
oral (15 minutes)
Radiation quality is the determinant of the radiobiological effectiveness of ionising radiation since the molecular damage at the DNA level mainly responsible for observed cytogenetic effects mirrors the pattern of energy deposition by radiation tracks. It is known that high-LET radiations, whose energy loss in the traversed matter is described by the Bragg curve, are more effective than x- or...
Dr
Vladimir Potetnya
(Medical Radiological Research Center)
18/10/2012, 12:00
Charged Particles in Medicine and Space Research
oral (15 minutes)
Cytogenetic studies of neutron dose rate effect were carried out at the BARS-6 pulse reactor (IPPE, Obninsk, Russia) using human lymphocytes in G0 and G1 (15 hours after PGA stimulation) stages. Blood samples in plastic tubes were irradiated in water/ice-filled flasks with unfiltered radiation (Dn/Dg=1.5-2) from two unshielded metallic active zones. Equal doses in the range 0.3-1.8 Gy were...
Dr
Aroumougame Asaithamby
(Department of Radiation Oncology, University of Texas Southwestern Medical Center at Dallas, Texas, USA)
18/10/2012, 12:15
Charged Particles in Medicine and Space Research
oral (15 minutes)
Clustered DNA damages induced by ionizing radiation are refractory to repair and may trigger carcinogenic events for reasons that are not understood. Here, we employ an in situ method to directly monitor induction and repair of clustered DNA lesions at the single-cell level. We showed, consistent with biophysical modeling, that the kinetics of loss of clustered DNA lesions was substantially...
