EUROPEAN RADIATION RESEARCH 2012

Session

Poster Session 2

17 Oct 2012, 16:00

Vietri sul Mare

6. ACCUMULATION OF RADIONUCLIDES IN VEGETABLE SOME CROPS IN ZONES OF THE ARMENIAN NPP

Mrs Laura Ghalachyan (G.S. Davtyan Institute of Hydroponics Problems NAS RA)

17/10/2012, 16:00

Radioecology

poster preferred

Artificial radionuclides (RN, 90Sr-T1/2=28.6 years, 137Cs-T1/2=30.1 years) dangerous for health are released to ecosystems because of human influence in the field of nuclear energetics RN can penetrate into human organism through water-soil-plant chain. Armenian NPP (ANPP, opened in 1976, operated till 1989, reoperated in 1995) is in a densly populated area of the Ararat Valley with intensive...

8. WATER STREAM HYDROPONICS AS A RADIOECOLOGICALY PROFITABLE BIOTECHNOLOGICAL METHOD FOR PRODUCITON OF PLANTING MATERIAL

Mr Khachatur Mairapetyan (Hydroponics ploblems institute NAS RA)

17/10/2012, 16:01

Radioecology

poster preferred

Artificial radionuclides (ARN, 90Sr-T1/2=28.6 years, 137Cs-T1/2=30.1years) dangerous for health are released to ecosystems because of human influence in the field of nuclear energetics. ARN can penetrate into human organism and cause different diseases. At the institute (30km radius zone of the Armenian NPP) a modern system-water stream hydroponics (cylindrical, gully, continuous) with...

37. IRRADIATION OF LUMINOUS MARINE BACTERIA BY TRITIUM

Mrs Maria Selivanova (Siberian federal university)

17/10/2012, 16:02

Radioecology

poster preferred

Increase of radioactive contamination in the environment makes the effects of radiation on living organisms very important. Detailed investigations of irradiation of living organisms were conducted using simple assay systems. All biological assay systems are nonspecific and integral. These principal properties account for the field of application of bioassays. The use of microorganisms, of...

67. Microarray analysis of the transcriptional response to different doses of ionizing radiation in Salmonella enterica serovar Typhimurium

Dr Dongho Kim (Korea Atomic Energy Research Institute)

17/10/2012, 16:03

Other

poster preferred

Microarrays can be used to measure the expression of thousands of genes to identify the changes in expression between different biological states. To define the repertoire of Salmonella typhimurium genes responding to different doses of ionizing radiation (IR), 1, 10, and 100 Gy, transcriptome dynamics were examined using DNA microarrays. At least 74 genes were induced and 38 genes were...

89. INVESTIGATION OF RADIOACTIVITY IN THE HYDROPONIC AND WILD MEDICINAL RAW MATERIAL OF THYME

Dr Elmira Sargsyan (Institute of Hydroponics Problems NAS RA)

17/10/2012, 16:04

Radioecology

poster preferred

In the consequence of anthropogenic influence the artificial and natural radionuclids (RN) penetrate into the environment then through ecological chain enter in biogeochemical circulation which leads to their undesirable accumulation in the living organisms. The study of artificial (90Sr, 137Cs) and natural (U) RN accumulation in hydroponic and wild plants of Thymus (T) marshallianus Willd....

93. Risk assessment of lake fish exposure due to 137Cs radiation

Dr Marina Konstantinova (CENTER FOR PHYSICAL SCIENCES AND TECHNOLOGY)

17/10/2012, 16:05

Biological and Physical Dosimetry

poster preferred

Over the last few years increasing attention has been paid to the elements required for the estimation of risk of non-human biota related to ionizing radiation. Freshwater biota of a small humic lake, called Red, which became meromictic some thirty-five years ago due to the inflow of a large amount of humic water, was investigated. The bottom areas of this lake are related to the favorite...

113. Two-phase migration model of the radionuclide transfer from water into the lake bottom sediments

Dr Evaldas Maceika (State scientific research institute Center for Physical Sciences and Technology)

17/10/2012, 16:06

Radioecology

poster preferred

In scientific literature studying migration of radionuclides from water into soil and bottom sediments, the process is described by one-phase models. The main drawback of such models is related to the fact that the radionuclide diffusion coefficient in sediments decreases with time. However, analyses of radionuclide vertical profiles in carbonate bottom sediments as well as results of...

134. RADIOECOLOGICAL EVALUATION OF HYDROPONIC MEDICINAL RAW MATERIAL OF HYPERICUM PERFORATUM L.

Ms Anush Vardanyan (Institute of Hydroponics Problems, National Academy of Sciences, Republic of Armenia)

17/10/2012, 16:07

Radioecology

poster preferred

Contamination of environment by various wastes from industries, transports, agriculture and nuclear power stations is an actual subject for comprehensive study. Constantly, numerous radionuclides (RN) penetrate in the nature and accumulate extensively by plants and through ecological chain soil-plant-animal-human inpour into biogeochemical circulation resulting in their undesireable...

184. ENVIRONMENTAL ANALYSIS OF RADIOLOGICAL AGENT IDENTIFICATION LABORATORY AT BRAZILIAN ARMY TECHNOLOGICAL CENTER

Mr Jorge Alberto Valle da Silva (Brazilian Army Technological Center - CTEx)

17/10/2012, 16:08

Radioecology

poster preferred

Radiological analysis at Brazilian Army Technological Center (CTEx) has been performed since 1980s, in order to be applied environmental monitoring. Nowadays, analytical techniques such as gamma spectroscopy and total alpha/beta counting are performed by Chemical Biological and Nuclear Defense Division (DDQBN). Its major role is to support CTEx in development of searching about homeland...

38. HEALTH STATUS OF POPULATIONS AFFECTED BY THE CHERNOBYL ACCIDENT

Dr Pavel Marozik (Institute of Genetics & Cytology NAS Belarus, Minsk, Belarus)

17/10/2012, 16:09

Non-Targeted Effects of Radiation

poster preferred

For a long time it was considered that genetic effects of irradiation are related only to direct DNA damage. But a lot of evidence suggests the existence of a phenomenon of information transfer from irradiated cells to non-irradiated (radiation induced bystander effect, RIBE). The specific nature of these factors and mechanism of RIBE are still unknown. Effects of bystander factors induced in...

66. Reduction of Spontaneous Mutagenesis by Bystander Cell Death in V79 Cells

Dr Munetoshi Maeda (Proton Medical Research Group, Research and Development Department, The Wakasa Wan Energy Research Center, WERC)

17/10/2012, 16:10

Non-Targeted Effects of Radiation

poster preferred

Bystander responses have generated considerable interest in the field of modern radiobiology because of their non-liner relationship with low-dose radiation. Moreover, potential carcinogenic risks are considered to be increased by bystander responses because harmful consequences such as cell death and DNA damage typically induced in bystander cells. Using the synchrotron X-ray microbeam...

151. Low dose/dose rate gamma irradiation facility for in vitro biological systems

Dr Giuseppe Esposito (Istituto Superiore di Sanità and INFN Gr. Coll. Sanità, Roma, Italy)

17/10/2012, 16:11

Non-Targeted Effects of Radiation

poster preferred

The response of in vitro biological systems to low dose and low dose rate irradiations is a topic that is important both for the determination of still unclear basic mechanisms and for its implications in radiation protection and therapy (late response of healthy tissue). The study of low dose/dose rate effects requires experiments performed under strictly controlled conditions where the dose...

152. Bleomycin - induced bystander effects and stress response

Dr Iulia Diana Savu (Horia Hulubei National institute of Physics and Nuclear Engineering – IFIN-HH)

17/10/2012, 16:12

Non-Targeted Effects of Radiation

poster preferred

Purpose: In the present study, we propose to evaluate the ability of bleomycin to induce bystander effects and the stress response mechanisms that might be involved in this process. Materials and Methods: L929 fibroblasts were treated with different concentrations (less than 60 µg/ml) of a DNA damaging agent, bleomycin. These cells were assessed for DNA damage, cell death and induction of...

172. The influence of the number of irradiated cells in the spatial distribution of bystander effects

Mrs Ana Belchior (Instituto Superior Técnico, Instituto Tecnológico e Nuclear)

17/10/2012, 16:13

Non-Targeted Effects of Radiation

poster preferred

The need to better understand the risk associated with the exposure to low doses of ionizing radiation is the driving force of several studies currently being performed. In view of adaptive responses, bystander effects and cell death, the validity of the linear non-threshold relationship between dose and subsequent effects has been challenged. The way cell populations react to low radiation...

197. In vitro and in vivo gene expression studies highlight differential expression profiles of low doses of ionizing radiation when compared to high doses

Mr Houssein El Saghire (Faculty of Life Sciences and Medicine, Ghent University AND Radiobiology Unit, Belgian Nuclear Research Centre, Belgium)

17/10/2012, 16:14

Non-Targeted Effects of Radiation

poster preferred

DNA microarrays are widely utilized to study cellular responses of complex nature, and when studying ionizing radiation, especially when the interest is low doses, we are faced with the dilemma of technique sensitivity, except for γ-H2AX foci. Previous studies have shown that microarrays are effective in the determination of pathways and genes that can be induced by ionizing radiation. In our...

229. The LNGS underground facility for biological experiments in reduced radiation environment

Dr Maria Antonella Tabocchini (Istituto Superiore di Sanità & INFN RM1. Gr coll Sanità, Rome, Italy)

17/10/2012, 16:15

Non-Targeted Effects of Radiation

poster preferred

All humans are continuously exposed to ionizing radiations (IR) both from natural sources, such as cosmic rays and radioactive decay products, and from man-made sources, as in diagnostic radiology, nuclear medicine or radiotherapy. Although much is known about the effects of exposure to medium/high doses of IR, biological and health effects at low doses are still broadly debated. Among the...

230. Dose and Spatial Effects in Distant Bystander Radiation Signaling In vivo: Implications for Tumorigenesis

Dr Simona Leonardi (ENEA CR Casaccia, Rome, Italy)

17/10/2012, 16:16

Non-Targeted Effects of Radiation

poster preferred

The aim of this work was to investigate the dose and spatial dependence of abscopal radiation effects occurring in vivo in the mouse, along with their tumorigenic potential in radiosensitive Patched1 heterozygous (Ptc1+/-) central nervous system (CNS). Ptc1+/- mice, carrying a germ-line heterozygous inactivating mutation in the Ptc1 gene, and uniquely susceptible to radiation damage in...

233. TGF-β and the Radiation Bystander Effect in Human Peripheral Blood mononuclear cells – preliminary results and potential applications

Mr Peter Ostoich (National Centre for Radiobiology and Radiation Protection, Sofia, Bulgaria)

17/10/2012, 16:17

Non-Targeted Effects of Radiation

poster preferred

The radiation bystander effect, whereby cells not directly exposed to ionizing radiation exhibit characteristic signs of radiation damage was first observed twenty years ago and remains an active area of research within radiobiology. This effect has since been demonstrated in a number of experimental systems; the literature confirms the relevance of the bystander effect to human peripheral...

74. Effects of EMP Exposure on Rat Brain Microglia

Prof. Gui-Rong Ding (Department of Radiation Medicine, Fourth Military Medical University)

17/10/2012, 16:18

Non-Ionizing Radiation

poster preferred

Objective: To investigate the effect of electromagnetic pulse (EMP) exposure on rat brain microglia and its possible mechanism. Methods: Adult male SD rats and primary cultured rat brain microglia cells were exposed or sham exposed to EMP at 200 kV/m for 200 pulses, the repetition rate was 1 Hz. The activation of microglia was determined by CD11b immunocytochemistry, the protein and...

193. Health Effects of Occupational Exposure to Pulsed Microwave Radiation in Military Radar Personnel

Mr Shahram Taeb (Shiraz University of Medical Sciences)

17/10/2012, 16:19

Non-Ionizing Radiation

poster preferred

Radar workers are exposed to pulsed high frequency electromagnetic fields. In this study, health effects of these radiations in personnel who routinely work with radar systems are investigated. The 28-item General Health Questionnaire was used as a self-administered tool for assessment of general mental health and mental distress. One hundred workers occupationally exposed to radar radiations...

213. Effect of surgical stress and immobility of the hormone Ghrelin and body weight and food consumption in adult male rats

Mr mojtaba keshavarz (Msc Of Developmental Biology , Department Of Biology,Islamic azad university of jahrom , jahrom,, Fars, Iran.)

17/10/2012, 16:20

Other

poster preferred

Introduction: Ghrelin is a hormone that was discovered in 1999 by kojima where stomach cells that secrete this hormone increases growth hormone secretion and the amount of food consumed has a significant role stress can increase blood levels of Ghrelin is the purpose of this study surgical stress and immobility in periods 7 and 14 days on the secretion of Ghrelin and body weight and food is...

22. Retrospective (1992-2009) analysis of data on oxidative homeostasis state in clean-up workers of Chornobyl accident aftermath

Ms Alla Kubashko (Research Center for Radiation Medicine)

17/10/2012, 16:21

Oxidative Stress

poster preferred

Increase of chronic diseases number among Chornobyl Nuclear Power Plant (ChNPP) accident clean-up workers require more detailed study of mechanisms forming pathological background for such clinical implications. The prolonged disturbances of oxidative homeostasis (OH) on the top of radiation induced molecular-genetic disorders can be a ponderable factor for morphofunctional changes which...

76. The serum levels of 8-oxo-dG as a biomarker of individual radiosensitivity after in vitro exposure of whole blood.

Mrs Sara Skiöld (Stockholm University)

17/10/2012, 16:22

Oxidative Stress

poster preferred

About 20% of patients receiving radiotherapy will develop adverse reactions to the therapy and 5% of these patients will develop severe reactions. Theoretically, all cancers could be controlled if a sufficiently high radiation dose could be delivered to the target. However, doses used in radiotherapy are adapted to the tolerance of the most sensitive patients. Thus, radiotherapy would greatly...

120. LIPID PEROXIDATION IN TISSUES OF MICE UNDER IRRADIATION AT LOW DOSES AND DIFFERENT DOSE RATE

Prof. Lyudmila Shishkina (no)

17/10/2012, 16:23

Oxidative Stress

poster preferred

Up to now the question is discussed dose or dose rate is the more significant for the development of biological consequences under the irradiation of animals especially at low doses. Earlier in laboratory experiments and investigations on rodents caught at areas with different levels of the radioactive contamination the high sensitivity of the lipid peroxidation (LPO) regulatory system...

148. Reactivity of Resorufin-based Fluorogenic Boronate Probe PC1 Towards ROS/RNS and Its Use in The Studies of Peroxynitrite Reactivity

Dr Adam Sikora (Institute of Applied Radiation Chemistry, Lodz University of Technology, Lodz, Poland)

17/10/2012, 16:24

Oxidative Stress

poster preferred

It is known that aryl boronates can react with hydrogen peroxide, and hypochlorite with the formation of corresponding phenols. Previously, we have shown that arylboronic acids react rapidly, directly and stoichiometrically with peroxynitrite with the formation of corresponding phenols, as major products (85-90%). High reactivity toward peroxynitrite makes them promising probes for the...

192. Lack of Oxidative Stress after Short-Term Exposure to Naturally Elevated Levels of Gamma Radiation in Ramsar

Prof. SMJ Mortazavi (Shiraz University of Medical Sciences)

17/10/2012, 16:25

Oxidative Stress

poster preferred

Ramsar, a city in northern Iran, has areas with some of the highest recorded levels of natural radiation among inhabited areas measured on the earth. In some areas of Ramsar, residents receive an annual radiation dose from background radiation that is about 13 times higher than the 20 mSv/y that is considered as a dose limit for radiation workers. These residents have lived for many...

202. Reduction of Peroxyl Radicals of Amino Acid Derivatives by Urate

Anastasia S. Domazou (Swiss Federal Institute of Technology Zurich (ETH Zürich))

17/10/2012, 16:26

Oxidative Stress

poster preferred

Proteins are important targets of partly reduced oxygen species (PROS) that are responsible for biological damage under oxidative stress. Protein oxidation results in the formation of amino acid radicals (AA•) randomly on the protein surface; in the presence of oxygen, further reaction may yield protein peroxyl radicals and protein hydroperoxides. All these species are likely to propagate...

207. The effects of gamma-radiation-induced damage on environmental isolates of the baker’s yeast Saccharomyces cerevisiae

Ms Maggie Wear (Uniformed Services University of the Health Sciences)

17/10/2012, 16:27

Oxidative Stress

poster preferred

Recent work has shown that proteins are critical targets in irradiated bacteria governing their survival. Our laboratory and others have shown that DNA and protein damage are uncoupled in radiation-resistant prokaryotes exposed to gamma-rays. Radiation-resistant bacteria such as Deinococcus radiodurans are extremely resistant to protein oxidation, but they are as susceptible to...

212. The Protective Effects of Vitamin C and E, Against Oxidative Stress Induced by Sulfasalazine in theTestis of Male Adult Rats

Mr ahmad mozafar (Msc Of Developmental Biology , Department Of Biology,Islamic azad university of jahrom , jahrom, Fars, Iran.)

17/10/2012, 16:28

Oxidative Stress

poster preferred

Background & Objective: Sulfasalazine (SASP) is a drug used for the treatment of inflammatory bowel diseases. SASP causes testicular damage. The aim of this study was to verify whether or not an additional supply of vitamin E or C or together prevent the toxic effect of SASP on the rat spermatogenesis. Materials & methods: Adult male wistar rats (150-200 gr) were divided into five groups...

99. Late oral mucosa alterations after radiotherapy for head and neck cancer: cytological study of radiation induced epithelial cells injury

Dr Patrizia Massaro (Fondazione I.R.C.C.S Policlinico San Matteo, Pavia)

17/10/2012, 16:29

Normal Tissue Damage

poster preferred

Introduction and aims: Radiotherapy for head and neck (H&N) district malignancies may induce permanent tissue damage leading to multiple life-long side effects that place patients at continual risk for oral sequelae. In our study late toxicity after radiotherapy for H&N cancer has been assessed by exfoliative oral cytology. Matherials and methods: Eligibility criteria were: age between 30...

101. hUCB-MSC ameliorates irradiation-induced intestinal injury in murine model

Mr Sehwan Shim (Korea institute of radiological & medical sciences)

17/10/2012, 16:30

Normal Tissue Damage

poster preferred

Purpose: Gastrointestinal syndrome after high-dose acute radiation exposure (GI-ARS) is life-threatening problem. In this study, we examined the radiation mitigation effects of human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSC) on intestinal damage of gamma-irradiated rats. Methods: to investigate the effect of hUCB-MSC on mitigation of intestinal injury following...

122. Prediction of normal tissue radiosensitivity in gynecological and prostate cancer patients from polymorphisms in XRCC1, XRCC3 and OGG1 genes and radiation-induced apoptosis in peripheral blood lymphocytes

Ms Węgierek-Ciuk Aneta (Dept. of Radiobiology and Immunology, Jan Kochanowski University, Kielce, Poland)

17/10/2012, 16:31

Normal Tissue Damage

poster preferred

Several observations indicate that normal tissue hypersensitivity may be related to certain genetic factors. In view of the importance of DNA repair in cell and tissue response to radiation, single nucleotide polymorphisms (SNPs) in the genes responsible for DNA damage signaling and repair pathways seem to be suitable candidates in the search for the genetic basis of clinical normal tissue...

143. Cytokine secretion profiles and signaling pathways analysis of endothelial cells exposed to high doses of ionizing radiation

Mr Georges TARLET (Institute for Radiological and Nuclear Safety)

17/10/2012, 16:32

Normal Tissue Damage

poster preferred

Vascular injury is one of the most common effects of ionizing radiation on normal tissues due to the high radiation sensitivity of endothelial cells. The knowledge of molecular mechanisms involved in endothelium dysfunction following radiation exposure is needed to identify therapeutic targets and to develop strategies to prevent and/or reduce effects of irradiation. Methods : To clarify...

155. Is late radiation toxicity dependant on genotype? A study of patients with osteoradionecrosis

Mr Karl Brehwens (Centre for Radiation Protection Research, GMT Department, Stockholm University, Sweden)

17/10/2012, 16:33

Oxidative Stress

poster preferred

Approximately 20% of cancer patients undergoing radiotherapy (RT) experience some kind of adverse reaction and 5% experience severe reaction in healthy tissues. Recent data have highlighted the importance of individual radiosensitivity dependent on genotype, but there is a paucity of studies on late adverse effects, since these endpoints are difficult to determine. In this study, we...

166. Early impairment of spatial cognition after local brain irradiation with carbon ions

Dr Nobuhiko Takai (Pharmaceutical Sciences, Nagasaki International University)

17/10/2012, 16:34

Normal Tissue Damage

poster preferred

Cerebral dysfunction is one of the major concerns associated with radiotherapy of brain tumors and acute lymphoblastic leukemia. Side effects such as learning impairment and cognitive dysfunction are reported on the central nervous system (CNS) tissue after exposure to radiation during cancer therapy. This study investigated early effects on the cognitive function and microvessel density (MVD)...

170. Association of DNA Damage and Repair with Radiotherapy Induced Acute Skin Reactions in Breast Cancer Subjects

Prof. Satish B S Rao (Division of Radiobiology & Toxicology, Manipal Life Sciences Centre, Manipal University)

17/10/2012, 16:35

Normal Tissue Damage

poster preferred

With improving overall survival rates, there is emerging focus on the quality of life after adjuvant cancer treatment. During radiotherapy, unacceptable normal tissue toxicity is the major limiting factor for delivering a tumoricidal dose. Therefore, it is of great importance to determine whether variations in inherent cellular radiosensitivity along with extrinsic factors have greater...

219. Variation in tumour and normal tissue radiosensitivity in patients with breast cancer as detected by the alkaline comet assay

Mr Tim Rattay (University of Leicester)

17/10/2012, 16:36

Non-Targeted Effects of Radiation

poster preferred

INTRODUCTION: For high survival cancers such as breast cancer, the ability to identify radiosensitive patients in advance would allow personalized treatment to lower adverse side effects. The alkaline comet assay appears to be a highly sensitive and reproducible test to measure DNA breaks induced by ionizing radiation. To date, most studies using the comet assay to assess radiosensitivity...

235. The role of apoptosis in the oral mucositis – experimental studies

Dr Eva Bozsaky (Medical University Vienna, Christian Doppler Lab for Medical Radiation Oncology)

17/10/2012, 16:37

Normal Tissue Damage

poster preferred

Oral mucositis (OM) is a frequent dose-limiting side effect of radiotherapy of head-and-neck tumours. The pathophysiological basis of the response of the mucosal lining is the radiation-induced impairment of proliferation in the germinal layer of the mucosal epithelium. The contribution of apoptotic processes in both the epithelium and the associated endothelium are currently discussed...

253. Follistatin is a potential mitigator of radiation induced fibrosis and a predictor for radiosensitivity

Alesia Ivashkevich (Centre for Innate Immunity and Infectious Disease, Monash Institute of Medical Research, Monash University, 27-31 Wright Street, Clayton, Victoria, 3168, Australia)

17/10/2012, 16:38

Normal Tissue Damage

poster preferred

Late normal tissue side effects from cancer radiotherapy can manifest as fibrosis and severely affect quality of life. Decreasing the treatment dose to spare the normal tissues and avoid fibrosis interferes with the efficiency of tumour control. Discovery of novel treatments to avoid adverse responses to radiation would benefit radiotherapy outcomes immensely. Exon expression analysis...

254. Ionizing radiation induces acute and chronic modifications of the transcriptional profile of endothelial cells

Valérie Buard (Institute for Radiological Protection and Nuclear Safety)

17/10/2012, 16:39

Normal Tissue Damage

poster preferred

Normal tissue damage after radiation therapy is characterised by a chronic altered phenotype of endothelium. Molecular mechanisms involved in the initiation and the acquisition of a chronic activated phenotype of endothelial cells after radiation exposure remain unclear. The aim of this work is to characterize in vitro molecular actors involved in both the acute and late activated phenotype of...

125. Live-cell imaging study of mitochondrial morphology in mammalian cells exposed to X-rays

Dr Miho Noguchi (Advanced Science Ressearch Center, Japan Atomic Energy Agency)

17/10/2012, 16:40

Other

poster preferred

Recent reports suggest that extranuclear targets in cytoplasm may have a role in mediating radiation effects in mammalian cells exposed to ionizing radiation (Tartier et al., 2007, Maeda et al., 2010). Mitochondria, a kind of major organelles, are distributed throughout cytoplasm. They contain their own genome, and mediate essential cell functions, such as generation of ATP and regulation of...

204. The effect of increasing X-ray doses on normal and malignant cell migration

Dr Jeffrey Crosbie (University of Melbourne)

17/10/2012, 16:41

Other

poster preferred

A novel, synchrotron-based approach, known as microbeam radiotherapy (MRT) has the potential to revolutionise the way radiotherapy is performed. MRT uses a lattice of kilovoltage X-ray microbeamlets, with each beamlet being 10-50 microns wide with centre-to-centre separation of 100-300 microns. It is not known why normal tissues can tolerate such high doses of radiation, or why tumor...

81. A NEW THYROID SPECTROMETER BASED ON A LaBr3(Ce) DETECTOR FOR OCCUPATIONAL INTERNAL RADIATION EXPOSURE MONITORING

Dr MIRELA ANGELA SAIZU ("Horia Hulubei" National Institute for Physics and Nuclear Engineering)

17/10/2012, 16:42

Internal Emitters

poster preferred

The Whole Body Monitoring Laboratory from IFIN-HH, Magurele, Romania, performs, periodically, according to its Quality Assurance Programme, in vivo monitoring of the thyroid in order to be determined the I-131 retention by gamma spectrometry. The thyroid measurements are required, strictly, from radiation protection reasons, for people involved in nuclear medicine activities from hospitals and...

105. Effect of Internal Contamination with HTO on the Innate Anti-Tumour and Inflammatory Reactions in Mice

Dr Ewa M. Nowosielska (Military Institute of Hygiene and Epidemiology)

17/10/2012, 16:43

Internal Emitters

poster preferred

One of the significant sources of internal radiation exposure of workers and members of the public is tritium, a β--emitting isotope of hydrogen that binds with hydroxyl radicals to form the easily internalized tritiated water (HTO). As with other exposures to low-LET ionizing radiation deposition of HTO in the body leads to absorption of energy in the sensitive targets which, in the long run,...

171. CHANGES IN RADIOSENSITIVITY TO GAMMA-RAYS OF LYMPHOCYTES FROM HYPERTHYROID PATIENTS TREATED WITH I-131

Dr Valentina Dini (Departement of Technology and Health, Istituto Superiore di Sanita', Rome, Italy; INFN, Sez. Roma1- Gruppo Collegato Sanità, Rome, Italy)

17/10/2012, 16:44

Internal Emitters

poster preferred

The therapeutic application of I-131 is a widespread clinical practice for the treatment of thyroid cancer and hyperthyroidism. Although it has almost no side effects in adults, it is desirable to optimize the applied dose to each patient to maximize the clinical result with acceptable damage to healthy tissues. A previous study showed the occurrence of an adaptive response (AR) in peripheral...