Mrs
Laura Ghalachyan
(G.S. Davtyan Institute of Hydroponics Problems NAS RA)
17/10/2012, 16:00
Radioecology
poster preferred
Artificial radionuclides (RN, 90Sr-T1/2=28.6 years, 137Cs-T1/2=30.1 years) dangerous for health are released to ecosystems because of human influence in the field of nuclear energetics RN can penetrate into human organism through water-soil-plant chain. Armenian NPP (ANPP, opened in 1976, operated till 1989, reoperated in 1995) is in a densly populated area of the Ararat Valley with intensive...
Mr
Khachatur Mairapetyan
(Hydroponics ploblems institute NAS RA)
17/10/2012, 16:01
Radioecology
poster preferred
Artificial radionuclides (ARN, 90Sr-T1/2=28.6 years, 137Cs-T1/2=30.1years) dangerous for health are released to ecosystems because of human influence in the field of nuclear energetics. ARN can penetrate into human organism and cause different diseases. At the institute (30km radius zone of the Armenian NPP) a modern system-water stream hydroponics (cylindrical, gully, continuous) with...
Mrs
Maria Selivanova
(Siberian federal university)
17/10/2012, 16:02
Radioecology
poster preferred
Increase of radioactive contamination in the environment makes the effects of radiation on living organisms very important. Detailed investigations of irradiation of living organisms were conducted using simple assay systems. All biological assay systems are nonspecific and integral. These principal properties account for the field of application of bioassays. The use of microorganisms, of...
Dr
Dongho Kim
(Korea Atomic Energy Research Institute)
17/10/2012, 16:03
Other
poster preferred
Microarrays can be used to measure the expression of thousands of genes to identify the changes in expression between different biological states. To define the repertoire of Salmonella typhimurium genes responding to different doses of ionizing radiation (IR), 1, 10, and 100 Gy, transcriptome dynamics were examined using DNA microarrays. At least 74 genes were induced and 38 genes were...
Dr
Elmira Sargsyan
(Institute of Hydroponics Problems NAS RA)
17/10/2012, 16:04
Radioecology
poster preferred
In the consequence of anthropogenic influence the artificial and natural radionuclids (RN) penetrate into the environment then through ecological chain enter in biogeochemical circulation which leads to their undesirable accumulation in the living organisms. The study of artificial (90Sr, 137Cs) and natural (U) RN accumulation in hydroponic and wild plants of Thymus (T) marshallianus Willd....
Dr
Marina Konstantinova
(CENTER FOR PHYSICAL SCIENCES AND TECHNOLOGY)
17/10/2012, 16:05
Biological and Physical Dosimetry
poster preferred
Over the last few years increasing attention has been paid to the elements required for the estimation of risk of non-human biota related to ionizing radiation. Freshwater biota of a small humic lake, called Red, which became meromictic some thirty-five years ago due to the inflow of a large amount of humic water, was investigated. The bottom areas of this lake are related to the favorite...
Dr
Evaldas Maceika
(State scientific research institute Center for Physical Sciences and Technology)
17/10/2012, 16:06
Radioecology
poster preferred
In scientific literature studying migration of radionuclides from water into soil and bottom sediments, the process is described by one-phase models. The main drawback of such models is related to the fact that the radionuclide diffusion coefficient in sediments decreases with time. However, analyses of radionuclide vertical profiles in carbonate bottom sediments as well as results of...
Ms
Anush Vardanyan
(Institute of Hydroponics Problems, National Academy of Sciences, Republic of Armenia)
17/10/2012, 16:07
Radioecology
poster preferred
Contamination of environment by various wastes from industries, transports, agriculture and nuclear power stations is an actual subject for comprehensive study. Constantly, numerous radionuclides (RN) penetrate in the nature and accumulate extensively by plants and through ecological chain soil-plant-animal-human inpour into biogeochemical circulation resulting in their undesireable...
Mr
Jorge Alberto Valle da Silva
(Brazilian Army Technological Center - CTEx)
17/10/2012, 16:08
Radioecology
poster preferred
Radiological analysis at Brazilian Army Technological Center (CTEx) has been performed since 1980s, in order to be applied environmental monitoring. Nowadays, analytical techniques such as gamma spectroscopy and total alpha/beta counting are performed by Chemical Biological and Nuclear Defense Division (DDQBN). Its major role is to support CTEx in development of searching about homeland...
Dr
Pavel Marozik
(Institute of Genetics & Cytology NAS Belarus, Minsk, Belarus)
17/10/2012, 16:09
Non-Targeted Effects of Radiation
poster preferred
For a long time it was considered that genetic effects of irradiation are related only to direct DNA damage. But a lot of evidence suggests the existence of a phenomenon of information transfer from irradiated cells to non-irradiated (radiation induced bystander effect, RIBE). The specific nature of these factors and mechanism of RIBE are still unknown. Effects of bystander factors induced in...
Dr
Munetoshi Maeda
(Proton Medical Research Group, Research and Development Department, The Wakasa Wan Energy Research Center, WERC)
17/10/2012, 16:10
Non-Targeted Effects of Radiation
poster preferred
Bystander responses have generated considerable interest in the field of modern radiobiology because of their non-liner relationship with low-dose radiation. Moreover, potential carcinogenic risks are considered to be increased by bystander responses because harmful consequences such as cell death and DNA damage typically induced in bystander cells.
Using the synchrotron X-ray microbeam...
Dr
Giuseppe Esposito
(Istituto Superiore di Sanitร and INFN Gr. Coll. Sanitร , Roma, Italy)
17/10/2012, 16:11
Non-Targeted Effects of Radiation
poster preferred
The response of in vitro biological systems to low dose and low dose rate irradiations is a topic that is important both for the determination of still unclear basic mechanisms and for its implications in radiation protection and therapy (late response of healthy tissue). The study of low dose/dose rate effects requires experiments performed under strictly controlled conditions where the dose...
Dr
Iulia Diana Savu
(Horia Hulubei National institute of Physics and Nuclear Engineering โ IFIN-HH)
17/10/2012, 16:12
Non-Targeted Effects of Radiation
poster preferred
Purpose: In the present study, we propose to evaluate the ability of bleomycin to induce bystander effects and the stress response mechanisms that might be involved in this process.
Materials and Methods: L929 fibroblasts were treated with different concentrations (less than 60 ยตg/ml) of a DNA damaging agent, bleomycin. These cells were assessed for DNA damage, cell death and induction of...
Mrs
Ana Belchior
(Instituto Superior Tรฉcnico, Instituto Tecnolรณgico e Nuclear)
17/10/2012, 16:13
Non-Targeted Effects of Radiation
poster preferred
The need to better understand the risk associated with the exposure to low doses of ionizing radiation is the driving force of several studies currently being performed. In view of adaptive responses, bystander effects and cell death, the validity of the linear non-threshold relationship between dose and subsequent effects has been challenged. The way cell populations react to low radiation...
Mr
Houssein El Saghire
(Faculty of Life Sciences and Medicine, Ghent University AND Radiobiology Unit, Belgian Nuclear Research Centre, Belgium)
17/10/2012, 16:14
Non-Targeted Effects of Radiation
poster preferred
DNA microarrays are widely utilized to study cellular responses of complex nature, and when studying ionizing radiation, especially when the interest is low doses, we are faced with the dilemma of technique sensitivity, except for ฮณ-H2AX foci. Previous studies have shown that microarrays are effective in the determination of pathways and genes that can be induced by ionizing radiation. In our...
Dr
Maria Antonella Tabocchini
(Istituto Superiore di Sanitร & INFN RM1. Gr coll Sanitร , Rome, Italy)
17/10/2012, 16:15
Non-Targeted Effects of Radiation
poster preferred
All humans are continuously exposed to ionizing radiations (IR) both from natural sources, such as cosmic rays and radioactive decay products, and from man-made sources, as in diagnostic radiology, nuclear medicine or radiotherapy. Although much is known about the effects of exposure to medium/high doses of IR, biological and health effects at low doses are still broadly debated. Among the...
Dr
Simona Leonardi
(ENEA CR Casaccia, Rome, Italy)
17/10/2012, 16:16
Non-Targeted Effects of Radiation
poster preferred
The aim of this work was to investigate the dose and spatial dependence of abscopal radiation effects occurring in vivo in the mouse, along with their tumorigenic potential in radiosensitive Patched1 heterozygous (Ptc1+/-) central nervous system (CNS). Ptc1+/- mice, carrying a germ-line heterozygous inactivating mutation in the Ptc1 gene, and uniquely susceptible to radiation damage in...
Mr
Peter Ostoich
(National Centre for Radiobiology and Radiation Protection, Sofia, Bulgaria)
17/10/2012, 16:17
Non-Targeted Effects of Radiation
poster preferred
The radiation bystander effect, whereby cells not directly exposed to ionizing radiation exhibit characteristic signs of radiation damage was first observed twenty years ago and remains an active area of research within radiobiology. This effect has since been demonstrated in a number of experimental systems; the literature confirms the relevance of the bystander effect to human peripheral...
Prof.
Gui-Rong Ding
(Department of Radiation Medicine, Fourth Military Medical University)
17/10/2012, 16:18
Non-Ionizing Radiation
poster preferred
Objective: To investigate the effect of electromagnetic pulse (EMP) exposure on rat brain microglia and its possible mechanism. Methods: Adult male SD rats and primary cultured rat brain microglia cells were exposed or sham exposed to EMP at 200 kV/m for 200 pulses, the repetition rate was 1 Hz. The activation of microglia was determined by CD11b immunocytochemistry, the protein and...
Mr
Shahram Taeb
(Shiraz University of Medical Sciences)
17/10/2012, 16:19
Non-Ionizing Radiation
poster preferred
Radar workers are exposed to pulsed high frequency electromagnetic fields. In this study, health effects of these radiations in personnel who routinely work with radar systems are investigated. The 28-item General Health Questionnaire was used as a self-administered tool for assessment of general mental health and mental distress. One hundred workers occupationally exposed to radar radiations...
Mr
mojtaba keshavarz
(Msc Of Developmental Biology , Department Of Biology,Islamic azad university of jahrom , jahrom,, Fars, Iran.)
17/10/2012, 16:20
Other
poster preferred
Introduction:
Ghrelin is a hormone that was discovered in 1999 by kojima where stomach cells that secrete this hormone increases growth hormone secretion and the amount of food consumed has a significant role stress can increase blood levels of Ghrelin is the purpose of this study surgical stress and immobility in periods 7 and 14 days on the secretion of Ghrelin and body weight and food is...
Ms
Alla Kubashko
(Research Center for Radiation Medicine)
17/10/2012, 16:21
Oxidative Stress
poster preferred
Increase of chronic diseases number among Chornobyl Nuclear Power Plant (ChNPP) accident clean-up workers require more detailed study of mechanisms forming pathological background for such clinical implications. The prolonged disturbances of oxidative homeostasis (OH) on the top of radiation induced molecular-genetic disorders can be a ponderable factor for morphofunctional changes which...
Mrs
Sara Skiรถld
(Stockholm University)
17/10/2012, 16:22
Oxidative Stress
poster preferred
About 20% of patients receiving radiotherapy will develop adverse reactions to the therapy and 5% of these patients will develop severe reactions. Theoretically, all cancers could be controlled if a sufficiently high radiation dose could be delivered to the target. However, doses used in radiotherapy are adapted to the tolerance of the most sensitive patients. Thus, radiotherapy would greatly...
Prof.
Lyudmila Shishkina
(no)
17/10/2012, 16:23
Oxidative Stress
poster preferred
Up to now the question is discussed dose or dose rate is the more significant for the development of biological consequences under the irradiation of animals especially at low doses. Earlier in laboratory experiments and investigations on rodents caught at areas with different levels of the radioactive contamination the high sensitivity of the lipid peroxidation (LPO) regulatory system...
Dr
Adam Sikora
(Institute of Applied Radiation Chemistry, Lodz University of Technology, Lodz, Poland)
17/10/2012, 16:24
Oxidative Stress
poster preferred
It is known that aryl boronates can react with hydrogen peroxide, and hypochlorite with the formation of corresponding phenols. Previously, we have shown that arylboronic acids react rapidly, directly and stoichiometrically with peroxynitrite with the formation of corresponding phenols, as major products
(85-90%). High reactivity toward peroxynitrite makes them promising probes for the...
Prof.
SMJ Mortazavi
(Shiraz University of Medical Sciences)
17/10/2012, 16:25
Oxidative Stress
poster preferred
Ramsar, a city in northern Iran, has areas with some of the highest recorded levels of natural radiation among inhabited areas measured on the earth. In some areas of Ramsar, residents receive an annual radiation dose from background radiation that is about 13 times higher than the 20 mSv/y that is considered as a dose limit for radiation workers. These residents have lived for many...
Anastasia S. Domazou
(Swiss Federal Institute of Technology Zurich (ETH Zรผrich))
17/10/2012, 16:26
Oxidative Stress
poster preferred
Proteins are important targets of partly reduced oxygen species (PROS) that are responsible for biological damage under oxidative stress. Protein oxidation results in the formation of amino acid radicals (AAโข) randomly on the protein surface; in the presence of oxygen, further reaction may yield protein peroxyl radicals and protein hydroperoxides. All these species are likely to propagate...
Ms
Maggie Wear
(Uniformed Services University of the Health Sciences)
17/10/2012, 16:27
Oxidative Stress
poster preferred
Recent work has shown that proteins are critical targets in irradiated bacteria governing their survival. Our laboratory and others have shown that DNA and protein damage are uncoupled in radiation-resistantย prokaryotesย exposed to gamma-rays. Radiation-resistant bacteria such asย Deinococcus radioduransย are extremely resistant to protein oxidation, but theyย areย as susceptible to...
Mr
ahmad mozafar
(Msc Of Developmental Biology , Department Of Biology,Islamic azad university of jahrom , jahrom, Fars, Iran.)
17/10/2012, 16:28
Oxidative Stress
poster preferred
Background & Objective: Sulfasalazine (SASP) is a drug used for the treatment of inflammatory bowel diseases. SASP causes testicular damage. The aim of this study was to verify whether or not an additional supply of vitamin E or C or together prevent the toxic effect of SASP on the rat spermatogenesis.
Materials & methods: Adult male wistar rats (150-200 gr) were divided into five groups...
Dr
Patrizia Massaro
(Fondazione I.R.C.C.S Policlinico San Matteo, Pavia)
17/10/2012, 16:29
Normal Tissue Damage
poster preferred
Introduction and aims: Radiotherapy for head and neck (H&N) district malignancies may induce permanent tissue damage leading to multiple life-long side effects that place patients at continual risk for oral sequelae. In our study late toxicity after radiotherapy for H&N cancer has been assessed by exfoliative oral cytology.
Matherials and methods: Eligibility criteria were: age between 30...
Mr
Sehwan Shim
(Korea institute of radiological & medical sciences)
17/10/2012, 16:30
Normal Tissue Damage
poster preferred
Purpose: Gastrointestinal syndrome after high-dose acute radiation exposure (GI-ARS) is life-threatening problem. In this study, we examined the radiation mitigation effects of human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSC) on intestinal damage of gamma-irradiated rats.
Methods: to investigate the effect of hUCB-MSC on mitigation of intestinal injury following...
Ms
Wฤgierek-Ciuk Aneta
(Dept. of Radiobiology and Immunology, Jan Kochanowski University, Kielce, Poland)
17/10/2012, 16:31
Normal Tissue Damage
poster preferred
Several observations indicate that normal tissue hypersensitivity may be related to certain genetic factors. In view of the importance of DNA repair in cell and tissue response to radiation, single nucleotide polymorphisms (SNPs) in the genes responsible for DNA damage signaling and repair pathways seem to be suitable candidates in the search for the genetic basis of clinical normal tissue...
Mr
Georges TARLET
(Institute for Radiological and Nuclear Safety)
17/10/2012, 16:32
Normal Tissue Damage
poster preferred
Vascular injury is one of the most common effects of ionizing radiation on normal tissues due to the high radiation sensitivity of endothelial cells.
The knowledge of molecular mechanisms involved in endothelium dysfunction following radiation exposure is needed to identify therapeutic targets and to develop strategies to prevent and/or reduce effects of irradiation.
Methods : To clarify...
Mr
Karl Brehwens
(Centre for Radiation Protection Research, GMT Department, Stockholm University, Sweden)
17/10/2012, 16:33
Oxidative Stress
poster preferred
Approximately 20% of cancer patients undergoing radiotherapy (RT) experience some kind of adverse reaction and 5% experience severe reaction in healthy tissues. Recent data have highlighted the importance of individual radiosensitivity dependent on genotype, but there is a paucity of studies on late adverse effects, since these endpoints are difficult to determine. In this study, we...
Dr
Nobuhiko Takai
(Pharmaceutical Sciences, Nagasaki International University)
17/10/2012, 16:34
Normal Tissue Damage
poster preferred
Cerebral dysfunction is one of the major concerns associated with radiotherapy of brain tumors and acute lymphoblastic leukemia. Side effects such as learning impairment and cognitive dysfunction are reported on the central nervous system (CNS) tissue after exposure to radiation during cancer therapy. This study investigated early effects on the cognitive function and microvessel density (MVD)...
Prof.
Satish B S Rao
(Division of Radiobiology & Toxicology, Manipal Life Sciences Centre, Manipal University)
17/10/2012, 16:35
Normal Tissue Damage
poster preferred
With improving overall survival rates, there is emerging focus on the quality of life after adjuvant cancer treatment. During radiotherapy, unacceptable normal tissue toxicity is the major limiting factor for delivering a tumoricidal dose. Therefore, it is of great importance to determine whether variations in inherent cellular radiosensitivity along with extrinsic factors have greater...
Mr
Tim Rattay
(University of Leicester)
17/10/2012, 16:36
Non-Targeted Effects of Radiation
poster preferred
INTRODUCTION:
For high survival cancers such as breast cancer, the ability to identify radiosensitive patients in advance would allow personalized treatment to lower adverse side effects. The alkaline comet assay appears to be a highly sensitive and reproducible test to measure DNA breaks induced by ionizing radiation.
To date, most studies using the comet assay to assess radiosensitivity...
Dr
Eva Bozsaky
(Medical University Vienna, Christian Doppler Lab for Medical Radiation Oncology)
17/10/2012, 16:37
Normal Tissue Damage
poster preferred
Oral mucositis (OM) is a frequent dose-limiting side effect of radiotherapy of head-and-neck tumours. The pathophysiological basis of the response of the mucosal lining is the radiation-induced impairment of proliferation in the germinal layer of the mucosal epithelium. The contribution of apoptotic processes in both the epithelium and the associated endothelium are currently discussed...
Alesia Ivashkevich
(Centre for Innate Immunity and Infectious Disease, Monash Institute of Medical Research, Monash University, 27-31 Wright Street, Clayton, Victoria, 3168, Australia)
17/10/2012, 16:38
Normal Tissue Damage
poster preferred
Late normal tissue side effects from cancer radiotherapy can manifest as fibrosis and severely affect quality of life. Decreasing the treatment dose to spare the normal tissues and avoid fibrosis interferes with the efficiency of tumour control. Discovery of novel treatments to avoid adverse responses to radiation would benefit radiotherapy outcomes immensely. Exon expression analysis...
Valรฉrie Buard
(Institute for Radiological Protection and Nuclear Safety)
17/10/2012, 16:39
Normal Tissue Damage
poster preferred
Normal tissue damage after radiation therapy is characterised by a chronic altered phenotype of endothelium. Molecular mechanisms involved in the initiation and the acquisition of a chronic activated phenotype of endothelial cells after radiation exposure remain unclear. The aim of this work is to characterize in vitro molecular actors involved in both the acute and late activated phenotype of...
Dr
Miho Noguchi
(Advanced Science Ressearch Center, Japan Atomic Energy Agency)
17/10/2012, 16:40
Other
poster preferred
Recent reports suggest that extranuclear targets in cytoplasm may have a role in mediating radiation effects in mammalian cells exposed to ionizing radiation (Tartier et al., 2007, Maeda et al., 2010). Mitochondria, a kind of major organelles, are distributed throughout cytoplasm. They contain their own genome, and mediate essential cell functions, such as generation of ATP and regulation of...
Dr
Jeffrey Crosbie
(University of Melbourne)
17/10/2012, 16:41
Other
poster preferred
A novel, synchrotron-based approach, known as microbeam radiotherapy (MRT) has the potential to revolutionise the way radiotherapy is performed. MRT uses a lattice of kilovoltage X-ray microbeamlets, with each beamlet being 10-50 microns wide with centre-to-centre separation of 100-300 microns. It is not known why normal tissues can tolerate such high doses of radiation, or why tumor...
Dr
MIRELA ANGELA SAIZU
("Horia Hulubei" National Institute for Physics and Nuclear Engineering)
17/10/2012, 16:42
Internal Emitters
poster preferred
The Whole Body Monitoring Laboratory from IFIN-HH, Magurele, Romania, performs, periodically, according to its Quality Assurance Programme, in vivo monitoring of the thyroid in order to be determined the I-131 retention by gamma spectrometry. The thyroid measurements are required, strictly, from radiation protection reasons, for people involved in nuclear medicine activities from hospitals and...
Dr
Ewa M. Nowosielska
(Military Institute of Hygiene and Epidemiology)
17/10/2012, 16:43
Internal Emitters
poster preferred
One of the significant sources of internal radiation exposure of workers and members of the public is tritium, a ฮฒ--emitting isotope of hydrogen that binds with hydroxyl radicals to form the easily internalized tritiated water (HTO). As with other exposures to low-LET ionizing radiation deposition of HTO in the body leads to absorption of energy in the sensitive targets which, in the long run,...
Dr
Valentina Dini
(Departement of Technology and Health, Istituto Superiore di Sanita', Rome, Italy; INFN, Sez. Roma1- Gruppo Collegato Sanitร , Rome, Italy)
17/10/2012, 16:44
Internal Emitters
poster preferred
The therapeutic application of I-131 is a widespread clinical practice for the treatment of thyroid cancer and hyperthyroidism. Although it has almost no side effects in adults, it is desirable to optimize the applied dose to each patient to maximize the clinical result with acceptable damage to healthy tissues. A previous study showed the occurrence of an adaptive response (AR) in peripheral...
