EUROPEAN RADIATION RESEARCH 2012

Session

Internal Emitters

INE

19 Oct 2012, 10:00

Vietri sul Mare

236. Radioactivity from within: Using radionuclides to track health and disease

Dr Sharon Stone-Elander (Karolinska Institute, Stockholm, Sweden)

19/10/2012, 10:00

Internal Emitters

oral (invited speaker)

Molecules appropriately equipped with signal-transmitting (radioactive) tags are critical tools for our ability to non-invasively track the molecular processes that are fundamental for maintenance of life, the development of disease and the efficacy of the interventions designed to stop, reverse or stabilize those disease processes. The radionuclide chosen for this molecular imaging is...

154. Application of the Comet (SCGE) and Micronucleus (MN) Assay to Estimate Health Risk due to Exposure at Low and High Doses of 131I

Prof. Antonina Cebulska-Wasilewska (Institute of Nuclear Physics PAN, Kraków, Poland)

19/10/2012, 11:30

Internal Emitters

oral (15 minutes)

Iodine-131 is used in nuclear medicine both diagnostically and therapeutically to improve health conditions by early disease detection and restore health by slowing an overactive thyroid or even killing cancer cells. An emerge of the 131I among emission of various radioactive isotopes, might be one of the first sign of misfortunate accidental exposures from various radiation sources, including...

90. Radiation-induced DNA Damage and Repair in Normal Thyroid Epithelial Cells: Comparison of Cell Cycle Stage

Dr Madeleine Nordén Lyckesvärd (Institute of Clinical Sciences, Dept of Oncology, Sahlgrenska Academy, University of Gothenburg)

19/10/2012, 11:50

Internal Emitters

oral (15 minutes)

The thyroid is considered to be among the most radiosensitive organs. However, the biological nature of thyroid radiosensitivity as compared to other organs is largely unknown. The interest of using high-LET radiation in cancer treatment has increased during recent years because of its high efficiency in inducing biological damage and beneficial dose distribution when compared to low-LET...

165. Influence of I-125 labeled TFO in SCL-II cells on cell survival, cell cycle and DSB induction

Mr Volker Dahmen (Radiation Biology Group, Department of Safety and Radiation Protection, Forschungszentrum Jülich, 52425 Jülich, Germany)

19/10/2012, 12:10

Internal Emitters

oral (15 minutes)

Triplex-forming oligonucleotides (TFO) are able to bind DNA in a sequence specific manner and are a promising tool to manipulate genes or gene regulatory units in a cellular environment. TFO posses a therapeutic potential e.g. as a carrier molecule for Alpha- or Auger-Electron-Emitter (AEE) to target specific DNA sequences in tumour cells. We established a method for the effective labeling of...