Dr
Michele Martin
(Laboratory of Genomics and Radiobiology of Keratinopoiesis, CEA, Evry, France)
19/10/2012, 10:00
Stem Cells Radiobiology
oral (invited speaker)
Skin is a well-known target of ionizing radiation as both complications in normal tissues and radiation-induced cancers have been documented, mainly developing from epidermis. Human epidermis is constantly renewed over a cycle of 28 days. This short-term constant renewal is due to a specific type of cells called the keratinocyte progenitors. They are located in the deepest layer of epidermis,...
Dr
Thomas Brunner
(Gray Institute, Oxford, UK)
19/10/2012, 11:00
Stem Cells Radiobiology
oral (invited speaker)
The field of cancer stem cell biology has a very short steep career from its infancy into the stage of clinical impact. Radiation oncologists are among the first to have recognised the importance of this field linking locoregional control with effective treatment of cancer stem cells with radiation. Better understanding of cancer stem cell biology in solid tumours is hypothesised to lead to a...
Dr
Gersende Alphonse
(Department of Cellular and Molecular Radiobiology EMR3738)
19/10/2012, 11:30
Stem Cells Radiobiology
oral (15 minutes)
Although hadrontherapy is a very promising alternative to conventional radiotherapy in a large variety of cancers, recent clinical trials have shown that local control of head-and-neck squamous cell carcinoma (HNSCC) is worse than expected due to loco-regional recurrence of the tumor. In order to obtain more insight into the mechanisms of tumour escape, we have investigated the role of cancer...
Dr
Vijay Singh
(Armed Forces Radiobiology Research Institute, USUHS, Bethesda, MD 20889, USA)
19/10/2012, 11:45
Stem Cells Radiobiology
oral (15 minutes)
The goal of this study was to elucidate the role of α-tocopherol succinate (TS)- and AMD3100-mobilized progenitors in mitigating the ionizing radiation-induced gastrointestinal (GI) syndrome in mice. We demonstrate the efficacy of a bridging therapy which will allow the lymphohematopoietic system of severely immunocompromised victims exposed to ionizing radiation to recover from high doses of...
Ms
Aušra Liubavičiūtė
(Vilnius university Center for Physical Sciences and Technology)
19/10/2012, 12:00
Stem Cells Radiobiology
oral (15 minutes)
Ionizing radiation (IR) has been proven to be a powerful medical treatment in cancer therapy. Rational and effective use of its killing power depends on understanding IR-mediated responses at the molecular, cellular and tissue levels. Increasing evidence supports that cancer stem-like cells (CSCs) play an important role in tumor regrowth and spread post radiotherapy, for they are resistant to...
Dr
Antonella Rosi
(Departement Technology and Health, Istituto Superiore di Sanità, Rome, Italy; INFN, Sez. Roma1-gruppo collegato Sanità, Rome, Italy)
19/10/2012, 12:15
Stem Cells Radiobiology
oral (15 minutes)
Among brain cancers, glioblastoma multiforme (GBM) is the most aggressive form with a very poor prognosis. Surgery is the first-line treatment for GBM patients, followed by combined radio- and chemotherapy. In the most recent models of cancer, the presence of cells with stem-like properties is deemed to contribute to high recurrence rate and failure of conventional treatments. Literature data...
