EUROPEAN RADIATION RESEARCH 2012

Session

Chromatin Remodelling and Radiation Epigenetics

CHR

17 Oct 2012, 13:30

Vietri sul Mare

201. Chromatin remodeling in response to DNA damage

Dr Haico Van Attikum (Leiden University Medical Center)

17/10/2012, 13:30

Chromatin Remodelling and Radiation Epigenetics

oral (invited speaker)

Our cells are constantly under attack from both endogenous and exogenous genotoxic agents. These genomic insults result in potentially harmful DNA lesions, the most dangerous of which is the chromosomal DNA double strand break (DSB). In response to a DSB cells activate a multitude of responses, including chromatin structural changes, cell cycle checkpoints and DNA repair. How cells signal and...

65. Radiation Epigenetics: Does ionizing radiation affect DNA methylation?

Dr Odilia Popanda (German Cancer Research Center (DKFZ))

17/10/2012, 14:00

Chromatin Remodelling and Radiation Epigenetics

oral (invited speaker)

Several manifestations of the radiation response such as bystander effects, adaptive processes, or transgenerational effects suggest involvement not only of genetic but also of epigenetic mechanisms. These might include transcriptional changes mediated by small RNAs, histone modifications or DNA methylation. Altered methylation of CpG sites can modify gene expression, induce genomic...

123. The influence of hypothermia on the ionizing radiation-induced γ-H2AX foci formation, micronuclei and clonogenic survival in A549 cells in relation to chromatin organization

Dr Halina Lisowska (Jan Kochanowski University, Department of Radiobiology and Immunology, Kielce, Poland)

17/10/2012, 14:30

Chromatin Remodelling and Radiation Epigenetics

oral (15 minutes)

It is well known that hypothermia during in vitro irradiation of human cells affects the level of clonogenic survival, frequency of chromosome aberrations and DNA supercoil rewinding. The mechanisms of the hypothermia effect are not known but it was suggested that it may be related to chromatin condensation. Elucidation of the mechanisms of the hypothermia effect is interesting and important...

137. What can we learn from localization microscopy? New insights into radiation induced changes of the chromatin nanostructure

Prof. Michael Hausmann (Kirchhoff-Institute for Physics, University of Heidelberg)

17/10/2012, 14:45

Chromatin Remodelling and Radiation Epigenetics

oral (15 minutes)

Spatial Position Determination Microscopy (SPDM) has become one of the established localisation microscopic techniques that enable effective light optical resolution in the nanometre range even in 3D conserved cell nuclei. It is based on the application of labelling fluorophores that can be switched between two different spectral states (e.g. off/on) to achieve a temporal isolation and thus a...

168. Epigenetic changes in human fibroblasts after low dose rate γ radiation

Ms Sara Shakeri Manesh (Stockholm University)

17/10/2012, 15:00

Chromatin Remodelling and Radiation Epigenetics

oral (15 minutes)

Recently, the epigenetic mechanisms involved in cancer development have come in focus. An epigenetic event refers to changes in gene expression controlled by histone modifications (acethylation) and/or DNA methylation (gene silencing). Accumulated evidence indicates that epigenetic modifications including persistent proteomic changes are among the delayed effects of ionizing radiation (IR). It...

217. Circulating MicroRNAs as Biomarkers in Radiation Therapy of Head and Neck Cancer Patients

Ms Isolde Summerer (Helmholtz Zentrum Muenchen)

17/10/2012, 15:15

Chromatin Remodelling and Radiation Epigenetics

oral (15 minutes)

MicroRNAs (miRNAs) are present in stable extracellular forms in body fluids such as liquor or blood plasma. Changes in the levels of circulating miRNAs of cancer patients are associated with malignant progression and have proven useful for the prediction of therapy responses. This study is intended to investigate if therapeutic irradiation induces changes in the plasma miRNA profiles of head...