Prof.
Alexandros Georgakilas
(East Carolina University)
17/10/2012, 10:00
Oxidative Stress
oral (invited speaker)
In cells and tissues there is a constant radiolytic attack that has exogenous or endogenous (intracellular) oxidative origin. During these attacks, although not in all cases, the primary damage is being induced by reactive oxygen species (ROS) and reactive nitrogen species (RNS). Examples of such species are the hydroxyl radical (OH·), O2·-, singlet oxygen (1O2) and peroxynitrite to others. ...
Prof.
Michael J. Davies
(The Heart Research Institute)
17/10/2012, 11:00
Oxidative Stress
oral (invited speaker)
Proteins are major targets for oxidative damage in biological systems due to their high abundance and rapid rates of reaction with radicals and other reactive species (e.g. UV-induced 1O2). Exposure of proteins to radicals generated by radiation, metal ion/hydroperoxide systems, peroxyl radicals, peroxynitrite, and activated white cells, results in the formation of protein-derived radicals....
Dr
Margarita Malakyan
(Scientific Centre of Radiation Medicine and Burns)
17/10/2012, 11:30
Oxidative Stress
oral (15 minutes)
Efficient bioactive antioxidant properties are exhibited by copper organic complexes along with their potential for prevention and/or treatment of ionizing radiation injury is mainly related to SOD- and Catalase-mimetic activities, as well as their respective facilitation of specific metalloelement-dependent enzyme de novo syntheses enabling them to prevent the accumulation of toxic metabolic...
Dr
Armida Torreggiani
(ISOF - CNR)
17/10/2012, 11:45
Oxidative Stress
oral (15 minutes)
Effects of radical stress in the biological environment is a very active field of research connecting varies discipline in life science. Exposure of proteins to free radicals may cause structural and functional changes. In particular, a single radical event that leads to an initial damage involving sulfur-containing amino acid residues could produce a reactive species able to damage another...
Dr
Chryssostomos Chatgilialoglu
(ISOF-CNR)
17/10/2012, 12:00
Oxidative Stress
oral (15 minutes)
Diffusible hydroxyl radicals (HO•) are known to react with DNA either by hydrogen abstraction from the 2-deoxyribose units or by addition to the base moieties. The majority of HO• attacks occur at the base moieties. However, there is growing evidence that the oxidation of 2-deoxyribose in DNA plays a critical role in the genetic toxicology of oxidative stress and inflammation.
About the...
Dr
Chantal Houée-Levin
(Laboratoire de Chimie Physique, Université Paris Sud, 91405 Orsay, France)
17/10/2012, 12:15
Oxidative Stress
oral (15 minutes)
It is known that methionine residues are easily oxidized non enzymatically to their sulfoxide form, and it has been proposed that this process in conjunction with its repair by methionine sulfoxide reductases would be a protective mechanisms towards oxidative stress. However oxidation of methionine does not always lead to the sulfoxide and in addition the susceptibility to oxidation of Met...
