Speaker
Dr
Tadashi Hongyo
(Osaka university)
Description
Irradiation in radiation therapy or bone marrow transplantation is known to cause damage to normal tissues. Although some substances are reported to suppress the damage(=radioprotectors), most of them have strong side effects and are not applicable in vivo. However, ascorbic acid and AHCC (Active Hexose Correlated Compound) are known as safe radioprotectors with antioxidant activity. While examining some radioprotectors using mice, we found that ascorbic acid and AHCC suppress fibrosis of lung and kidney caused by irradiation.
Materials and Methods: C57BL/6J mice,4-6weeks old were exposed to X-ray radiation in the following conditions; (1) 40Gy in 20 equal fractions, (2) 10Gy (single doze), (3)15 Gy (single doze), (4)20Gy (single doze) (In groups (1)-(4), exposure area was limited to the thorax and upper abdomen.), (5) 4Gy (single doze, total body irradiation).
Ascorbic acid, AHCC or sterile saline was administrated to each mouse by subcutaneous or intraperitoneal injection prior to irradiation.
We measured the Sircol level of lung and kidney and the Cystatin-C level of blood and urine of each mouse.
Results: Ascorbic acid and AHCC suppressed all the Sircol level of lung and kidney and Cystatin-C level of blood and urine in groups (1)(male), (2)(female) and (3), they suppressed the Sircol level of lung in groups (1)(female) and (4), and they also suppressed the Sircol level of lung and kidney in group (5).
Conclusions: Fibrosis of lung and kidney after irradiation was suppressed by ascorbic acid and AHCC. We might be able to prevent tissue impairment after irradiation by injecting ascorbic acid and/or AHCC.
Primary author
Dr
Tadashi Hongyo
(Osaka university)
Co-author
Dr
Hiroo Nakajima
(Osaka university)
