EUROPEAN RADIATION RESEARCH 2012

Modification of Immunity in Individuals with Late Radiation-Induced Neutropenia Using Hemopoietic Cells of Fetal Liver

18 Oct 2012, 16:56

1m

Poster Hall (Vietri sul Mare)

poster preferred Stem Cells Radiobiology Poster Session 3

Speaker

Mr Andrey Akleyev (Urals Research Center for Radiation Medicine)

Description

Modification of Immunity in Individuals with Late Radiation-Induced Neutropenia Using Hemopoietic Cells of Fetal Liver A. Akleyev, I. Dolgushin, G. Dimov The objective of the study was to assess the effect of hemopoietic cells of fetal liver (HC FL) on the key characteristics of innate immunity in persons who developed neutropenia at late time after a long-term chronic radiation exposure. The study group was composed of 12 residents of Techa riverside villages, including 10 women and 2 men aged 49-80 years, who were exposed to combined external gamma-raditaion and internal radiation, mostly due to 90Sr. Mean radiation dose to red bone marrow amounted to 0.92±0.46 Gy. To alleviate late radiation-induced neutropenia, HC FL were administered in the ratio of 1.4•106 cells per kg of the patient’s body weight. Immunological examinations were performed before the treatment was started, and then were repeated over the 18 months after the course of treatment (at month 6, 12 and 18). The number of neutrophils was constantly increasing over the whole period of observation, and it reached statistically significant differences from the initial values after 2 months, or later. The most substantial changes in the immune status following treatment with HC FL were manifested by the innate immunity. Attention is attracted to the progressive, in dynamics, suppression of innate immunity factors (reduced number of NK cells, phagocytic activity and values of intracellular oxygen-dependent metabolism of neutrophils and monocytes) playing a leading role in the maintenance of anti-tumor immunity. Patients treated with HC FL were also noted to have increased levels of proinflammatory cytokines while the levels of antiinflammatory cytokines were diminished.