Speaker
Dr
William F. Morgan
(Pacific Northwest National Laboratory, Richland, WA 99352, USA)
Description
“Non-targeted effects” is an all embracing term to include biological effects observed in cells that were themselves not irradiated, but were the progeny of an irradiated cell, or received signals from an irradiated cell. These non-targeted effects include a variety of endpoints usually associated with exposure to ionizing radiation, e.g., chromosomal rearrangements, mutation induction and cell killing. In terms of radiation protection, we have traditionally assumed that the irradiated volume is associated with potential risk for developing the delayed effects, including cancer, but there were negligible risks to the non-exposed tissues. Non-targeted effects however, suggest that the volume at risk for delayed effects may be greater than the volume actually irradiated. Nevertheless, there is only a risk if these non-targeted effects are detrimental, if they are beneficial, the implications for radiation protection may be very different. This presentation will discuss the implications of non-targeted effects for radiation protection given these different scenarios.
Primary author
Dr
William F. Morgan
(Pacific Northwest National Laboratory, Richland, WA 99352, USA)
