Speaker
Dr
Wolfgang Heidenreich
(Helmholtz Zentrum München, Neuherberg, Germany)
Description
We find evidence that the different susceptibility of BALB/C and CBA/Ca
mice to bone cancer after 227Thorium injection is mostly
due to different promotional responses to radiation. In BALB/C x CBA/Ca
back-crossed mice we analyzed the specific contribution of
two individual loci in the carcinogenic process. This analysis suggests
that the two high or low risk alleles are either acting on promotion, or
on the background parameters. Taken together with the comparison of
CBA/Ca and BALB/C mice, this suggests that the two loci are candidates
for modifying radiation-induced promotion.
Primary author
Dr
Wolfgang Heidenreich
(Helmholtz Zentrum München, Neuherberg, Germany)
Co-author
Dr
Michael Rosemann
(Helmholtz Zentrum München, Neuherberg, Germany)
