Serial macromolecular crystallography: developments for high throughput measurements over large parameter spaces

Jun 30, 2025, 12:10 PM
35m
Invited talk (35min) Session 3

Speaker

Dr Dominik Oberthür (Center for Free-electron Laser Science)

Description

Serial macromolecular crystallography (SMX) has emerged as a transformative technique enabling measurements across expansive parameter spaces in structural biology. Here I will talk about the evolution of serial crystallography techniques, particularly focusing on developments for time-resolved, pH-responsive, and temperature-controlled experiments and their application in unraveling dynamic structural changes within macromolecules. Highlighting recent results from X-ray Free Electron Laser (XFEL) and synchrotron sources, this presentation explores how serial crystallographyin in combination with cutting edge sample delivery and triggering methods can be used to advance our understanding of biological processes.

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Primary author

Dr Dominik Oberthür (Center for Free-electron Laser Science)

Presentation materials

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