Speaker
Summary
OPTIMIZATION OF 68GA SEPARATION FROM SOLID TARGETS IRRADIATED AT A MEDICAL CYCLOTRON
P. V. Grundlera,, I. Mateu, G. Dellepiane, S. Braccini, N. P. van der Meulena,
Center for Life Sciences, Paul Scherrer Institute, Villigen-PSI, Switzerland
Laboratory for High Energy Physics, University of Bern, Bern, Switzerland
Nuclear Engineering and Sciences, Paul Scherrer Institute, Villigen-PSI, Switzerland
Corresponding author: pascal.grundler@psi.ch
Gallium-68 is well established as a diagnostic radionuclide for PET imaging. It can be obtained from generators loaded with its parent, 68Ge, and eluted regularly. However, the supply of such generators and the activity which can be eluted are a limitation. The cross section of 68Zn for the nuclear reaction 68Zn(p,n)68Ga is suitably high (0.8 barn at 11.5 MeV)1 to produce high activities (>> 1GBq) with the relatively widely available 18 MeV medical cyclotrons.
The aim of this work was to develop a rapid purification method to isolate high purity 68Ga from metallic 68Zn targets, in a form to readily allow labelling of vector molecules at high molar activity.
This method ensures production of radionuclidically and radiochemically pure 68Ga at much higher activities, than available from a generator. The separation can be finalized in a short time with a simple two-column system, which can be implemented in a hot cell.
Full abstract attached as pdf: Grundler_Abstract_ICI12_final.pdf
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