Speaker
Summary
With the rapid development of precise cancer therapy, radiopharmaceuticals play an important role in the treatments of diffuse and metastatic tumors. Intravenous injection of the radiopharmaceuticals is a common administration method. Before the radiopharmaceuticals reach the tumors. some radioisotopes may undergo off-target effect and redistribution, usually accumulating in the liver, kidneys and bone marrow, causing radiation toxicity. Therefore, rapid dose assessments in vital organs such as liver during the treatments are very valuable for the safety evaluation of radiopharmaceuticals.
The IGFBP-3 level in the blood of mice is in a dose-dependent manner responding to ionizing radiation. This radiosensitive IGFBP-3 is mainly derived from the Kupffer cells in liver. Detecting the upregulation of IGFBP-3 may provide an effective and rapid assessment of radiation dose received by the liver during radiopharmaceuticals.
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