Conveners
High-performance preclinical and organ-specific systems
- Nuno Matela (Faculdade de Ciências da Universidade de Lisboa - Instituto de Biofísica e Engenharia Biomédica)
- Gabriela Llosa (Instituto de Física Corpuscular (IFIC/CSIC-UVEG))
Interesting radionuclides for nuclear medicine applications are usually produced in cyclotrons or in nuclear research reactors. These production methods are typically associated with highly enriched target costs and with contaminated products. In this context, the ISOLPHARM project, the medical application of ISOL SPES facility, aims to produce radionuclides of medical interest with high...
Single time point (STP) dosimetry offers a more convenient approach for clinical practice in radiopharmaceutical therapy (RPT) compared to conventional multiple time point (MTP). Despite numerous advancements, STP methods are limited and challenging by the need for strict and late timing in data acquisition. This study introduces a new concept of instant STP (iSTP), which is achieved by...
The SAFIR collaboration has developed a high-
performance PET insert compatible with a Bruker BioSpec 70/30
MRI scanner. This system, named SAFIR-II, was designed to
acquire data at activities of up to 500 MBq, enabling truly
simultaneous preclinical PET-MR imaging for mice and rats
using image acquisition times of up to 5 s.
We present an overview of the system’s design, as well...
Combining PET with other imaging techniques such as MR or US devices has gained interest to, for example, provide anatomical information or to improve drug administration, respectively.
Recently, special interest has arisen in the use of Focal US (FUS) to open the Brain Blood Barrier (BBB) to allow drugs pass through the brain. However, since the FUS lacks of visual information it is...
Commercially available PET/MRI scanners have been designed as whole-body systems. In these, PET spatial resolution and sensitivity are limited. Dedicated PET inserts can potentially overcome these limitations. The EU H2020 project HYPMED developed a local PET insert for a clinical 1.5 T MRI for breast cancer research.
The HYPMED insert combines a local MRI receive coil and two PET rings that...
PET is an ideal imaging modality for studying human brain biochemistry in vivo, but its potential is limited by its poor spatial resolution, which is currently well below the theoretical limit. The brain-dedicated UHR scanner is designed to achieve 2 µL volumetric resolution for accurate characterization of brain regions previously indistinguishable without MRI. Unlike most PET systems, the...
