Conveners
Poster Session
- Otto Muzik (Wayne State University)
Poster Session
- Sara Marcatili (CNRS LPSC)
This study presents a performance assessment of the Fast Tomographic Reconstruction (FTR) software for SAFIR PET insert with a non-cylindrical geometry. For this purpose, an image quality phantom and a Derenzo phantom were measured in the SAFIR-I and SAFIR-II scanners. The PET data were reconstructed by FTR and the well-known Software for Tomographic Image Reconstruction (STIR) and then...
Background: Organs-on-Chips (OOCs) are a novel technology that aim to
mimic the functions and physiology of human organs in a laboratory setting. Positron Emission Tomography (PET) is a widely-used imaging modality that enables non-invasive monitoring of biological processes in vivo. However, the spatial resolution of current small-scale PET systems is not sufficient for OOC imaging. One of...
Genetic factors play a crucial role in diagnosis and treatment of glioblastoma multiforme (GBM). The key biomarker, isocitrate dehydrogenase (IDH), is associated with better survival rates in its mutated forms than in wild-type. GBM diagnosis is complex due to tumor heterogeneity and risks in sampling, and this highlights the need for non-invasive diagnostic methods. We examined the impact of...
The SIG (Superconducting Ion Gantry) project focuses on enhancing online monitoring performances of in-beam PET during ion treatments, developing new image reconstruction algorithms and analyses that consider fast-decaying isotope signals. In this study we presented the performance evaluation of an in-beam PET system for carbon ion irradiations. The Range Verification System prototype under...
Introduction: Metabolic MRI can reveal simultaneous detection of multiple metabolites involved in cell proliferation and energy metabolism without the need for radio-isotopes, however, this is so far not available throughout the human body.
Methods: We designed a metabolic body MRI system using a double-tuned RF bore transmitter for uniform excitation of 2H and 31P spins, an 8-channel 1H...
Magnetic Resonance Fingerprinting (MRF) is an MR imaging technique that allows for the reconstruction of brain parameters within the same acquisition session. Despite its strengths, MRF implies a large amount of data to be processed and a complex analytical function that is not well defined. Recently, a neural network (NN) has been proposed to reconstruct brain quantitative maps starting from...
Introduction
Phosphorus (31P) MRSI monitors cardiac energetics in vivo. Previous studies have shown that the PCr/ATP ratio predicts mortality, however widespread use has been hampered by low sensitivity and spatial resolution.
We set out to solve these limitations by applying our dipole array coil for 31P MRSI at 7T. We aim to correlate the 7T 31P metabolic and cardiac energetics...
In the quantitative analyses of PET/MRI studies of Glioma patients, one of the crucial steps of the pipeline is represented by the fast, correct and, possibly, automatic segmentation of the tumors on multiple contrast MR images and PET. As a first preliminary study, we aim to compare the performance of the Swin Transformer and the current reference-standard nnUNET models in glioma...
This study aims to validate a template-based attenuation correction (AC) method for clinical brain PET systems without CT, previously proposed for the new NeuroLF brain-PET. Method: The validation process involved simulating a diverse (patients/tracers) set of clinical images. This is done by transforming 142 reference PET/MR and 8 PET/CT brain images to NeuroLF image space, converting them to...
Ultrahigh Field (UHF) MRI can provide images with unprecedented spatial resolution and SNR. Together with the increased sensitivity towards longitudinal relaxation time and magnetic susceptibility effects, this allows for a better tissue characterization (i.e., QSM, T1/T2 relaxometry). Efficient quantification of such parameters requires k-space sampling strategies which fully exploit the...
Phosphorus Magnetic Resonance Spectroscopy (31P MRS) is a non-invasive imaging technique that estimates concentrations of high-energy phosphates, offering insights into cell metabolism and neuromuscular disorders. Its clinical adoption is hindered by the need for specialized coils, but using a volume coil dual-tuned to 1H and 31P for 3D Magnetic Resonance Spectroscopy Imaging (3D-MRSI) can...
In this study, we employed a dedicated brain positron emission tomography (PET) scanner to simulate controlled motion through the use of a voxelised phantom. The resulting output was converted to listmode and subsequently transformed into pseudo-displacement time series via a moving mean technique. To locate time points of motion, we applied a statistical approach known as bottom-up...
This work explores the potential of panel detectors in developing flexible, modular PET scanners that can be tailored to specific patient needs and imaging objectives. It aims to demonstrate that even a simple 2-panel configuration can produce image quality suitable for practical applications, while using significantly less detector material compared to conventional PET scanners. The flat...
Lutetium yttrium oxyorthosilicate (LYSO) scintillation crystals are favored in positron emission tomography (PET) imaging for their high gamma-ray attenuation, satisfactory energy resolution, and rapid scintillation decay rates. The natural 176Lu isotope, with a half-life of 37.9 billion years, contributes a steady background radiation (BG) profile influenced by the crystals' geometry and...
This study introduces a novel small animal PET scanner aimed at overcoming limitations in preclinical imaging, specifically addressing the constraint of scanning a limited number of samples daily. The proposed scanner, featuring two flat panels with 16 BGO monolithic detectors each, demonstrates excellent spatial resolution (0.94 - 1.12 mm) with a 2mm depth of interaction (DOI) and high...
Segmenting regions of interest from total body Positron Emission Tomography/Computed Tomography (PET/CT) images is time-consuming and susceptible to variability between different operators. Automatic segmenting tools have been developed to address these challenges. In this study, we assessed the performance of two deep learning-based methods, MIWBAS and TotalSegmentator, in segmenting tissues...
Total-body Jagiellonian positron emission tomography (TB-J-PET) is based on long plastic scintillators [1] which decrease cost of the scanner [2]. TB PET scanners enable positronium imaging [3], measurements of polarization of photons [4] and beam therapy monitoring [5]. Development of TB-J-PET requires application of transparent plastic scintillators with low light attenuation [6] to build...
We implement and evaluate an energy-based scatter correction method for the Walk-Through PET (WT-PET) system. The WT-PET is a new, long axial field-of-view (AFOV) PET currently under development, based on a vertical, dual flat panel design using monolithic detector technology. In the energy-based scatter correction framework, scatter fractions are estimated from the dual energy distributions...
We report a novel portable All-Digital Helmet PET system with a hemispherical detector arrangement, based on the Multi Voltage Threshold technology. It allows to scan subjects in a standing, sitting, and lying position, facilitate emergency and interventional image-guided surgery. The scanner exhibits a noise equivalent count rate peak of (151 ยฑ 2) kcps at the activity of 40.65 kBq/mL, a...
The improvement of the timing performance is one of the main focus for several fields from big physics experiments to biomedical applications such as Time of Flight Positron Emission Tomography (ToF-PET). In this study we will present Single Photon Time Resolution (SPTR) and Coincidence Time Resolution (CTR) results of the recently introduced FBK NUV-HD Metal in Trench (MT) SiPM technology....
High-frequency (HF) front-end electronics offer a solution for exploiting fast light production in crystals and enhancing the performance of TOF-PET applications. Demonstrating improved time resolution by lowering the leading-edge detection threshold, they enable the use of the fastest photons, such as Cherenkov emission, and facilitate event discrimination in...
Within the last decade, algorithms built on convolution neural networks have become the de facto methods for semantic segmentation of imaging data and currently yield state-of-the-art results. Early efforts focused on natural images, but applications related to segmentation of 2D and 3D medical images soon followed. Currently however, most of the published literature in the segmentation space...
In this contribution we present a new total body SPECT gamma detector concept that relies on a tungsten metal frame, that serves both as a collimator and as a container for the scintillator segments, organized in a grid geometry with holes of few millimeter (diameter). The active material is organic scintillators enriched with high-Z elements allowing to profit of the extremely fast...
This study explores advancements in Time-of-Flight PET (TOF-PET) technology, specifically focusing on Redshifted Cherenkov Radiators (RCR) to enhance time resolution in radiation detectors. TOF-PET utilizes radiotracers labeled with positron-emitting radionuclides to track biological targets, aiding in diagnosis, treatment planning, and therapeutic monitoring. Recent hardware, radiotracer, and...
Scintillators substantially faster than LYSO:Ce are currently in demand for medical imaging, particularly, for TOF-PETs. Ce-doped multicomponent garnets are prospective candidates due to the freedom for engineering of their scintillation properties by varying their composition without detrimental deterioration of the crystal structure and by appropriate codoping. We report on a study of the...
We conduct a comprehensive analysis of the structural, electronic, and optical properties of bismuth-based scintillators, with a particular focus on the role of intrinsic defects and material composition.
We employ density functional theory (DFT) calculations with the PBE0 hybrid functional, we delve into the nuances of defect processes in Bi4Ge3Si3O12 (BGO) scintillators and explore the...
Purpose:
Monoamine oxidase-B (MAO-B) is one of the promising targets for the imaging of astrogliosis in the human brain. 18F-SMBT-1 was developed to image astrocytes in various neurological diseases (NDs). Nevertheless, 18F-SMBT-1 real time pharmacokinetics and metabolism in human subjects has not been studied yet.
Objective:
This study aimed to present the technical approaches for setting...
To achieve quantitatively accurate PET images, careful consideration of photon attenuation and scatter is essential. In PET/MR, patient attenuation and scatter correction (ASC) factors are often estimated using pseudo-CT images derived from MR images. Additionally, ASC due to MR hardware is addressed by registering a previously calculated attenuation map for MR coils to the patient attenuation...
Modern PET scanners are expected to achieve high sensitivity and exquisite time and position resolutions. These high-performance features can be accomplished by highly segmented scintillating crystal arrays and SiPM photosensors that are configured in a way to enable reconstruction of the depth of interaction (DoI) and the time of flight (ToF) using fast front-end electronics and data...
The Gamma-MRI project, funded under the EC FET Open Call aims developing molecular imaging capabilities based on gamma-rays emitted in the decay of hyperpolarised nuclei, which show a distinct anisotropy.
Despite significant advances over decades, MRI may still be hindered by low sensitivity, only partially compensated by recent advances in hyperpolarisation. On the other hand, the very...
PET is a vital molecular imaging modality using positron-emitting radionuclides to assess organ metabolism. Cherry et al. introduced an extended AFOV scanner in 2006 to overcome W-B PET limitations, yet designing an efficient crystal for T-B PET remains challenging. This study aims to optimize T-B PET with a new crystal design combining pixelated and monolithic advantages. Our simulated T-B...
Further improving the CTR of PET systems, achieving higher SNR gains or even dPEI puts demands on the fast-timing properties of PET detectors. One effective approach to optimize the timing performance of PET detectors is to fully utilize the prompt properties of Cherenkov photons by employing MCP-PMT. In this work, we established a PET imaging experimental setup using specially designed...
Recent technological advancement in nuclear medicine for image-guided radiation therapy and implementation of scanners with extended axial field of view with more detectors and data to be processed encourages real-time data processing where there is no need for all the information to be saved in data acquisition computer for post processing. Addressing this, we are utilizing an artificial...
In-beam PET imaging could herald a new era of more accurate and efficient dose in proton beam treatments with the potential to greatly improve patient outcomes. Such advancements would be even more important in the not-yet-understood but highly promising ultra-high dose and dose rate (FLASH) modality. In this talk we present our efforts to demonstrate the benefits of in-beam PET imaging. Our...
