Speaker
Description
Background: Performing hyperpolarized-13C MRI, knowledge of T2 values plays an important role for the sake of correct quantification of the metabolites (pyruvate, lactate, and bicarbonate) to increase the SNR and optimize image interpretation.
Aim(s): To estimate T2 values of pyruvate and lactate in both healthy and ischemic porcine kidneys at different concentrations (250mM, 150mM, and 80mM). To elucidate variation of T2 values under these circumstances.
Method: An animal study including 4 female Danish domestic pigs subjected to unilateral ischemic reperfusion injury.
Results: Linear regression showed positive correlation between increasing means of pyruvate and lactate T2 values in healthy kidneys and increasing concentrations of pyruvate-infusion.
Discussion: This preliminary study suggests a method determining T2-mapping in hyperpolarized-1313C MRI quantifying T2-values of pyruvate and lactate, which can be used to optimize SNR and image-interpretation. Further studies should explore other organs to determine organ-specific T2*-values and possible variations.
| Field | Systems and applications |
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