Conveners
Metabolic Imaging with PET, MR and PET/MR
- Michela Tosetti
- Paola Erba
3D density-weighted MRSI in combination with a frequency-tailored RF excitation pulse was designed, implemented and used to detect xenon gas in the lungs and xenon dissolved in lung tissue and blood. These images were used to calculate quantitative ratio maps of tissue-to-gas, blood-to-gas, and blood-to-tissue with good SNR.
The gold standard for imaging cerebral blood flow (CBF) and the cerebral metabolic rate of oxygen (CMRO2) are complex and invasive PET techniques. Hybrid PET/MR imaging can greatly simplify the procedures by acquiring PET data while simultaneously obtaining MRI measurements of whole-brain (WB) CBF and CMRO2. The aim of this work is to present hybrid PET/MR methods to image CBF and CMRO2....
FDG-PET has been proven so far to be a good modality for detecting functional brain changes in AD, for identifying changes in early AD, and in helping to differentiate AD from other causes of dementia. However, in recent years, novel MRI techniques, such as pCASL, showed to be promising in investigating brain metabolism and neurodegeneration.
In this work, a multiparametric approach is...
Abstract
Positron emission tomography (PET) can reveal metabolic activity in a voxel-wise manner. PET analysis is commonly performed statically by analyzing the standardized uptake value (SUV). A dynamic PET acquisition can provide a map of the spatio-temporal concentration of the tracer in vivo, hence conveying information about radiotracer delivery to tissue, its interaction with the...
In dynamic brain positron emission tomography (PET) studies, recovering the images in the missing time frame is often required in order to reduce the scanning protocol, or to perform kinetic modelling with sparse dynamic information. Likewise, the rapid dual-tracer studies, which aim to administer two tracers in a single scan staggered in time, will largely be benefitted if the later frames of...
