Dr
Paola Scifo
(Nuclear Medicine Dept, IRCCS San Raffaele Scientific Institute, Milan, Italy)
This preliminary work investigates how PET images are affected both quantitatively and qualitatively by the modification of spatial resolution and SNR of the MR sequences for AC (MRAC). Forty-six women with breast cancer underwent 18F-FDG PET/MR study using the 3T SIGNA PET/MR (General Electric Healthcare, Waukesha, WI, US) scanner. During breast prone PET scan, standard MRAC acquisition has been collected. Additionally, five different MRAC sequences were acquired with the same parameters of the standard MRAC (reference) except for parameters related to spatial resolution, SNR and shimming. Using offline GE Duetto Toolbox, six PET reconstructed images were obtained correcting attenuation with different MRACs. Eighty-three lesions (46 breast lesions and 37 active lymph nodes) were identified on the reference PET reconstructed images. SUVmax and SUVmean were calculated together with the percentage differences (SUVdiff) and the Root Mean Squared Error (RMSE) between the new set of images and the reference. Results from our work show that spatial resolution and SNR acquisition parameter modifications in MRAC sequences seem to affect SUVmean and SUVmax of the corresponding corrected PET images, but not significantly. The MRAC sequence acquired with improved shimming on the dorsal side has shown the highest effect on the RMSE both for AC-maps and for PET images.
Dr
Ilaria Neri
(Nuclear Medicine Dept, IRCCS San Raffaele Scientific Institute, Milan, Italy)
Dr
Monica Emendi
(Nuclear Medicine Dept, IRCCS San Raffaele Scientific Institute, Milan, Italy)
Dr
Carla Canevari
(Nuclear Medicine Dept, IRCCS San Raffaele Scientific Institute, Milan, Italy)
Dr
Annarita Savi
(Nuclear Medicine Dept, IRCCS San Raffaele Scientific Institute, Milan, Italy)
Dr
Valentino Bettinardi
(Nuclear Medicine Dept, IRCCS San Raffaele Scientific Institute, Milan, Italy)
Dr
Claudio Losio
(Radiology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy)
Dr
Elena Venturini
(Radiology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy)
Mr
Raffaele Menichini
(Nuclear Medicine Dept, IRCCS San Raffaele Scientific Institute, Milan, Italy)
Dr
Luca Presotto
(Nuclear Medicine Dept, IRCCS San Raffaele Scientific Institute, Milan, Italy)
Dr
Rosa Di Micco
( Breast Surgery Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy)
Prof.
Oreste Gentilini
( Breast Surgery Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy)
Prof.
Maria Picchio
(Nuclear Medicine Dept, IRCCS San Raffaele Scientific Institute, Milan, Italy)
Dr
Luigi Gianolli
(Nuclear Medicine Dept, IRCCS San Raffaele Scientific Institute, Milan, Italy)
Dr
Paola Scifo
(Nuclear Medicine Dept, IRCCS San Raffaele Scientific Institute, Milan, Italy)
